STRINGSTRING
GMPS GMPS PAICS PAICS PPAT PPAT AK3 AK3 UMPS UMPS CAD CAD APRT APRT LOC112062733 LOC112062733 ADA ADA PRPS2 PRPS2 UPRT UPRT LOC114485901 LOC114485901 NT5DC1 NT5DC1 LOC102994250 LOC102994250 URAD URAD ENSPCTP00005018822 ENSPCTP00005018822 LOC112063265 LOC112063265 PFAS PFAS LOC102983042 LOC102983042 ADSS1 ADSS1 UCK1 UCK1 ADSL ADSL ATIC ATIC LOC102977437 LOC102977437 LOC102985101 LOC102985101 LOC102992058 LOC102992058 XDH XDH ENSPCTP00005012780 ENSPCTP00005012780 PRPS1 PRPS1 PDE2A PDE2A LOC112062729 LOC112062729 AMPD2 AMPD2 UCKL1 UCKL1 ADK ADK DPYS DPYS ENSPCTP00005000408 ENSPCTP00005000408 ENSPCTP00005000448 ENSPCTP00005000448 PRTFDC1 PRTFDC1 ADSS ADSS ENSPCTP00005001421 ENSPCTP00005001421 AMPD1 AMPD1 RFK RFK NT5C1A NT5C1A GUK1 GUK1 IMPDH1 IMPDH1 UCK2 UCK2 UPP2 UPP2 AK1 AK1 ENSPCTP00005011914 ENSPCTP00005011914 AK4 AK4 IMPDH2 IMPDH2 DHODH DHODH GMPR2 GMPR2 UPB1 UPB1 NT5C2 NT5C2 DPYD DPYD GDA GDA DCK DCK ENSPCTP00005023524 ENSPCTP00005023524 NT5E NT5E NUDT2 NUDT2 LOC102975756 LOC102975756 ENSPCTP00005004895 ENSPCTP00005004895 GART GART ENSPCTP00005005081 ENSPCTP00005005081 ENSPCTP00005005741 ENSPCTP00005005741 LRGUK LRGUK ENSPCTP00005005934 ENSPCTP00005005934 ENSPCTP00005006127 ENSPCTP00005006127
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GMPSGMP synthase [glutamine-hydrolyzing]. (693 aa)
PAICSMultifunctional protein ADE2 isoform X2. (425 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (540 aa)
AK3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa)
UMPSUridine 5'-monophosphate synthase. (480 aa)
CADCAD protein isoform X2. (2225 aa)
APRTAdenine phosphoribosyltransferase isoform X2. (180 aa)
LOC112062733Uridine phosphorylase 1-like. (169 aa)
ADAAdenosine deaminase isoform X2. (352 aa)
PRPS2Ribose-phosphate pyrophosphokinase 2. (318 aa)
UPRTUracil phosphoribosyltransferase homolog. (307 aa)
LOC114485901Uracil phosphoribosyltransferase-like. (156 aa)
NT5DC15'-nucleotidase domain-containing protein 1 isoform X1. (452 aa)
LOC102994250Trifunctional purine biosynthetic protein adenosine-3 isoform X1. (433 aa)
URADLOW QUALITY PROTEIN: putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. (167 aa)
ENSPCTP00005018822annotation not available (269 aa)
LOC112063265Uridine phosphorylase 1-like. (169 aa)
PFASPhosphoribosylformylglycinamidine synthase isoform X2. (1338 aa)
LOC102983042Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (299 aa)
ADSS1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (457 aa)
UCK1Uridine-cytidine kinase; Belongs to the uridine kinase family. (277 aa)
ADSLAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (514 aa)
ATICBifunctional purine biosynthesis protein PURH. (592 aa)
LOC102977437LOW QUALITY PROTEIN: uncharacterized protein LOC102977437. (155 aa)
LOC102985101Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
LOC102992058Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
XDHXanthine dehydrogenase/oxidase. (219 aa)
ENSPCTP00005012780annotation not available (218 aa)
PRPS1Ribose-phosphate pyrophosphokinase 1. (318 aa)
PDE2APhosphodiesterase. (941 aa)
LOC112062729Uridine phosphorylase 1-like. (169 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (799 aa)
UCKL1Uridine-cytidine kinase; Belongs to the uridine kinase family. (549 aa)
ADKAdenosine kinase isoform X5. (362 aa)
DPYSDihydropyrimidinase isoform X1. (519 aa)
ENSPCTP00005000408annotation not available (218 aa)
ENSPCTP00005000448annotation not available (191 aa)
PRTFDC1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (225 aa)
ADSSAdenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
ENSPCTP00005001421annotation not available (162 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (779 aa)
RFKRiboflavin kinase isoform X1. (155 aa)
NT5C1ACytosolic 5'-nucleotidase 1A. (365 aa)
GUK1Guanylate kinase isoform X4. (198 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (571 aa)
UCK2Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa)
UPP2Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (318 aa)
AK1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (211 aa)
ENSPCTP00005011914annotation not available (109 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
DHODHDihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (395 aa)
GMPR2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (340 aa)
UPB1Beta-ureidopropionase. (378 aa)
NT5C2Cytosolic purine 5'-nucleotidase isoform X1. (573 aa)
DPYDDihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa)
GDAGuanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (472 aa)
DCKDeoxycytidine kinase isoform X1. (376 aa)
ENSPCTP00005023524annotation not available (222 aa)
NT5E5'-nucleotidase; Belongs to the 5'-nucleotidase family. (574 aa)
NUDT2Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Belongs to the Nudix hydrolase family. (147 aa)
LOC102975756Hypoxanthine-guanine phosphoribosyltransferase-like. (227 aa)
ENSPCTP00005004895annotation not available (155 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3. (437 aa)
ENSPCTP00005005081annotation not available (385 aa)
ENSPCTP00005005741annotation not available (155 aa)
LRGUKLeucine-rich repeat and guanylate kinase domain-containing protein. (831 aa)
ENSPCTP00005005934annotation not available (155 aa)
ENSPCTP00005006127annotation not available (313 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.