27 items (Physeter catodon) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPCTP00005000408	annotation not available (218 aa)
	ENSPCTP00005000448	annotation not available (191 aa)
	PRTFDC1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (225 aa)
	ADSS	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
	AMPD1	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (779 aa)
	IMPDH1	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (571 aa)
	NUDT2	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Belongs to the Nudix hydrolase family. (147 aa)
	LOC102975756	Hypoxanthine-guanine phosphoribosyltransferase-like. (227 aa)
	GMPS	GMP synthase [glutamine-hydrolyzing]. (693 aa)
	GART	Trifunctional purine biosynthetic protein adenosine-3. (437 aa)
	ENSPCTP00005005081	annotation not available (385 aa)
	PAICS	Multifunctional protein ADE2 isoform X2. (425 aa)
	PPAT	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (540 aa)
	APRT	Adenine phosphoribosyltransferase isoform X2. (180 aa)
	ADSS1	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (457 aa)
	ENSPCTP00005012780	annotation not available (218 aa)
	ATIC	Bifunctional purine biosynthesis protein PURH. (592 aa)
	ADSL	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (514 aa)
	PFAS	Phosphoribosylformylglycinamidine synthase isoform X2. (1338 aa)
	LOC102994250	Trifunctional purine biosynthetic protein adenosine-3 isoform X1. (433 aa)
	ADA	Adenosine deaminase isoform X2. (352 aa)
	ENSPCTP00005023524	annotation not available (222 aa)
	AMPD2	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (799 aa)
	LOC102992058	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
	LOC102985101	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
	ADK	Adenosine kinase isoform X5. (362 aa)
	IMPDH2	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)

Your Current Organism:

Physeter catodon

NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	ADK	ENSPCTP00005021172	ENSPCTP00005028593	Adenosine deaminase isoform X2.	Adenosine kinase isoform X5.	0.841
ADA	ADSL	ENSPCTP00005021172	ENSPCTP00005014883	Adenosine deaminase isoform X2.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.402
ADA	AMPD1	ENSPCTP00005021172	ENSPCTP00005001488	Adenosine deaminase isoform X2.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.546
ADA	AMPD2	ENSPCTP00005021172	ENSPCTP00005025423	Adenosine deaminase isoform X2.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.568
ADA	APRT	ENSPCTP00005021172	ENSPCTP00005008911	Adenosine deaminase isoform X2.	Adenine phosphoribosyltransferase isoform X2.	0.878
ADA	GART	ENSPCTP00005021172	ENSPCTP00005004913	Adenosine deaminase isoform X2.	Trifunctional purine biosynthetic protein adenosine-3.	0.446
ADA	GMPS	ENSPCTP00005021172	ENSPCTP00005004176	Adenosine deaminase isoform X2.	GMP synthase [glutamine-hydrolyzing].	0.638
ADA	IMPDH1	ENSPCTP00005021172	ENSPCTP00005002457	Adenosine deaminase isoform X2.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.459
ADA	IMPDH2	ENSPCTP00005021172	ENSPCTP00005031008	Adenosine deaminase isoform X2.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.459
ADA	LOC102994250	ENSPCTP00005021172	ENSPCTP00005019288	Adenosine deaminase isoform X2.	Trifunctional purine biosynthetic protein adenosine-3 isoform X1.	0.446
ADK	ADA	ENSPCTP00005028593	ENSPCTP00005021172	Adenosine kinase isoform X5.	Adenosine deaminase isoform X2.	0.841
ADK	ADSL	ENSPCTP00005028593	ENSPCTP00005014883	Adenosine kinase isoform X5.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.959
ADK	ADSS	ENSPCTP00005028593	ENSPCTP00005001181	Adenosine kinase isoform X5.	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.478
ADK	ADSS1	ENSPCTP00005028593	ENSPCTP00005009464	Adenosine kinase isoform X5.	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.431
ADK	AMPD1	ENSPCTP00005028593	ENSPCTP00005001488	Adenosine kinase isoform X5.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.958
ADK	AMPD2	ENSPCTP00005028593	ENSPCTP00005025423	Adenosine kinase isoform X5.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.966
ADK	APRT	ENSPCTP00005028593	ENSPCTP00005008911	Adenosine kinase isoform X5.	Adenine phosphoribosyltransferase isoform X2.	0.981
ADK	ATIC	ENSPCTP00005028593	ENSPCTP00005014693	Adenosine kinase isoform X5.	Bifunctional purine biosynthesis protein PURH.	0.806
ADK	ENSPCTP00005023524	ENSPCTP00005028593	ENSPCTP00005023524	Adenosine kinase isoform X5.	annotation not available	0.431
ADK	GART	ENSPCTP00005028593	ENSPCTP00005004913	Adenosine kinase isoform X5.	Trifunctional purine biosynthetic protein adenosine-3.	0.418