STRINGSTRING
PCNA PCNA RTEL1 RTEL1 GINS1 GINS1 LIG1 LIG1 ENSPCTP00005015830 ENSPCTP00005015830 ENSPCTP00005016534 ENSPCTP00005016534 MCM4 MCM4 ATAD5 ATAD5 GMNN GMNN LOC112062958 LOC112062958 POLA1 POLA1 BRCA2 BRCA2 ENSPCTP00005025390 ENSPCTP00005025390 RTF2 RTF2 RAD51 RAD51 UPF1 UPF1 GINS3 GINS3 MCM2 MCM2 CDC45 CDC45 DONSON DONSON MCM3 MCM3 DNA2 DNA2 CDT1 CDT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1270 aa)
GINS1DNA replication complex GINS protein PSF1 isoform X1. (196 aa)
LIG1DNA ligase. (921 aa)
ENSPCTP00005015830annotation not available (261 aa)
ENSPCTP00005016534annotation not available (102 aa)
MCM4DNA helicase; Belongs to the MCM family. (877 aa)
ATAD5ATPase family AAA domain-containing protein 5. (1897 aa)
GMNNGeminin isoform X2. (278 aa)
LOC112062958Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (228 aa)
POLA1DNA polymerase. (1468 aa)
BRCA2LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3429 aa)
ENSPCTP00005025390annotation not available (147 aa)
RTF2Protein RTF2 homolog isoform X1. (306 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
UPF1Regulator of nonsense transcripts 1 isoform X1. (1127 aa)
GINS3DNA replication complex GINS protein PSF3 isoform X1. (216 aa)
MCM2DNA helicase; Belongs to the MCM family. (823 aa)
CDC45Cell division control protein 45 homolog isoform X1. (567 aa)
DONSONProtein downstream neighbor of Son. (561 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (1254 aa)
CDT1DNA replication factor Cdt1. (545 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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