(11 nodes) High-density lipoprotein particle remodeling network (Physeter catodon)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	APOC3	Apolipoprotein C-III. (117 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). (265 aa)
	APOA2	Apolipoprotein A-II. (101 aa)
	LIPC	Hepatic triacylglycerol lipase. (500 aa)
	LIPG	Endothelial lipase. (500 aa)
	APOM	Apolipoprotein M isoform X1. (188 aa)
	LCAT	Phosphatidylcholine-sterol acyltransferase. (440 aa)
	SCARB1	Scavenger receptor class B member 1 isoform X2; Belongs to the CD36 family. (509 aa)
	PLA2G3	Group 3 secretory phospholipase A2 isoform X1. (516 aa)
	PLTP	Phospholipid transfer protein isoform X2. (496 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)

Your Current Organism:

Physeter catodon

NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOA1	APOA2	ENSPCTP00005026118	ENSPCTP00005001206	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein A-II.	0.656
APOA1	APOC3	ENSPCTP00005026118	ENSPCTP00005026206	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein C-III.	0.610
APOA1	APOE	ENSPCTP00005026118	ENSPCTP00005026101	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.809
APOA1	LCAT	ENSPCTP00005026118	ENSPCTP00005019868	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Phosphatidylcholine-sterol acyltransferase.	0.964
APOA1	LIPC	ENSPCTP00005026118	ENSPCTP00005008105	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Hepatic triacylglycerol lipase.	0.401
APOA1	LIPG	ENSPCTP00005026118	ENSPCTP00005014559	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Endothelial lipase.	0.464
APOA1	PLTP	ENSPCTP00005026118	ENSPCTP00005024305	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Phospholipid transfer protein isoform X2.	0.797
APOA2	APOA1	ENSPCTP00005001206	ENSPCTP00005026118	Apolipoprotein A-II.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	0.656
APOA2	APOC3	ENSPCTP00005001206	ENSPCTP00005026206	Apolipoprotein A-II.	Apolipoprotein C-III.	0.992
APOA2	APOE	ENSPCTP00005001206	ENSPCTP00005026101	Apolipoprotein A-II.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.960
APOA2	APOM	ENSPCTP00005001206	ENSPCTP00005017886	Apolipoprotein A-II.	Apolipoprotein M isoform X1.	0.677
APOA2	LCAT	ENSPCTP00005001206	ENSPCTP00005019868	Apolipoprotein A-II.	Phosphatidylcholine-sterol acyltransferase.	0.666
APOA2	LIPC	ENSPCTP00005001206	ENSPCTP00005008105	Apolipoprotein A-II.	Hepatic triacylglycerol lipase.	0.566
APOA2	PLTP	ENSPCTP00005001206	ENSPCTP00005024305	Apolipoprotein A-II.	Phospholipid transfer protein isoform X2.	0.495
APOA2	SCARB1	ENSPCTP00005001206	ENSPCTP00005021793	Apolipoprotein A-II.	Scavenger receptor class B member 1 isoform X2; Belongs to the CD36 family.	0.541
APOC3	APOA1	ENSPCTP00005026206	ENSPCTP00005026118	Apolipoprotein C-III.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	0.610
APOC3	APOA2	ENSPCTP00005026206	ENSPCTP00005001206	Apolipoprotein C-III.	Apolipoprotein A-II.	0.992
APOC3	APOE	ENSPCTP00005026206	ENSPCTP00005026101	Apolipoprotein C-III.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.958
APOC3	APOM	ENSPCTP00005026206	ENSPCTP00005017886	Apolipoprotein C-III.	Apolipoprotein M isoform X1.	0.542
APOC3	LCAT	ENSPCTP00005026206	ENSPCTP00005019868	Apolipoprotein C-III.	Phosphatidylcholine-sterol acyltransferase.	0.490