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GDF15 GDF15 PLS1 PLS1 ZMPSTE24 ZMPSTE24 APP APP SMO SMO MBD5 MBD5 SLC6A3 SLC6A3 NPY1R NPY1R GHSR GHSR PIK3CA PIK3CA EZR EZR FXN FXN CSF1 CSF1 GHRHR GHRHR PTCH1 PTCH1 GHRH GHRH RAI1 RAI1 CREB1 CREB1 CHD7 CHD7 ENSPCTP00005008487 ENSPCTP00005008487 ENSPCTP00005008865 ENSPCTP00005008865 MKKS MKKS ATRN ATRN SPTBN4 SPTBN4 GDF5 GDF5 PRLH PRLH BCL2 BCL2 STAT5B STAT5B STAT5A STAT5A STAT3 STAT3 LOC102980464 LOC102980464 PLAC8 PLAC8 GPAT4 GPAT4 ENSPCTP00005016493 ENSPCTP00005016493 HTRA2 HTRA2 BBS4 BBS4 FTO FTO BBS2 BBS2 GPAM GPAM NIPBL NIPBL MFSD2A MFSD2A LGMN LGMN SGPL1 SGPL1 IGF1 IGF1 PEX5 PEX5 FXN-2 FXN-2 POU3F2 POU3F2 VIL1 VIL1 ADRB1 ADRB1 CELF1 CELF1 LOC102987258 LOC102987258 PPIB PPIB GAMT GAMT DRD2 DRD2 TNKS2 TNKS2 ADRB2 ADRB2 SOCS2 SOCS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDF15Growth/differentiation factor 15. (305 aa)
PLS1Plastin-1. (630 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
APPAmyloid-beta precursor protein isoform X1. (770 aa)
SMOSmoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
MBD5methyl-CpG-binding domain protein 5 isoform X1. (1732 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
NPY1RNeuropeptide Y receptor type 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EZREzrin isoform X1. (586 aa)
FXNFrataxin, mitochondrial isoform X2. (215 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
GHRHRGrowth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (425 aa)
PTCH1Protein patched homolog 1. (1449 aa)
GHRHSomatoliberin. (106 aa)
RAI1Retinoic acid-induced protein 1. (1886 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
CHD7chromodomain-helicase-DNA-binding protein 7 isoform X1. (1134 aa)
ENSPCTP00005008487annotation not available (114 aa)
ENSPCTP00005008865annotation not available (224 aa)
MKKSMcKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin. (570 aa)
ATRNAttractin isoform X2. (1420 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2559 aa)
GDF5Growth/differentiation factor 5. (499 aa)
PRLHMelanophilin. (79 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (230 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
STAT5ASignal transducer and activator of transcription. (739 aa)
STAT3Signal transducer and activator of transcription. (801 aa)
LOC102980464Peroxisomal targeting signal 1 receptor-like isoform X1. (609 aa)
PLAC8Placenta-specific gene 8 protein-like. (113 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4. (456 aa)
ENSPCTP00005016493annotation not available (120 aa)
HTRA2Serine protease HTRA2, mitochondrial. (458 aa)
BBS4Bardet-Biedl syndrome 4 protein isoform X1. (519 aa)
FTOAlpha-ketoglutarate-dependent dioxygenase FTO isoform X1. (527 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (826 aa)
NIPBLNipped-B protein. (2802 aa)
MFSD2ASodium-dependent lysophosphatidylcholine symporter 1 isoform X2. (528 aa)
LGMNLegumain. (433 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (559 aa)
IGF1Insulin-like growth factor 1 transcript variant X1. (186 aa)
PEX5Peroxisomal biogenesis factor 5 isoform X1. (660 aa)
FXN-2Frataxin, mitochondrial isoform X1. (96 aa)
POU3F2POU domain protein. (437 aa)
VIL1Villin-1. (516 aa)
ADRB1Beta-1 adrenergic receptor. (470 aa)
CELF1CUGBP Elav-like family member 1 isoform X1. (514 aa)
LOC102987258Neuroendocrine secretory protein 55-like. (241 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
GAMTGuanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. (236 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (443 aa)
TNKS2Poly [ADP-ribose] polymerase. (1166 aa)
ADRB2Beta-2 adrenergic receptor isoform X1. (418 aa)
SOCS2Suppressor of cytokine signaling 2. (225 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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