STRINGSTRING
INSR INSR HSP90AA1 HSP90AA1 CLEC7A CLEC7A SMAD3 SMAD3 LOC112063002 LOC112063002 LOC114485589 LOC114485589 ASL ASL AGXT2 AGXT2 DDAH2 DDAH2 ENSPCTP00005015321 ENSPCTP00005015321 ASS1 ASS1 MMP8 MMP8 KLF2 KLF2 IL1B IL1B ESR1 ESR1 PTX3 PTX3 IFNG IFNG PKD2 PKD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INSRInsulin receptor isoform X1. (871 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (733 aa)
CLEC7AC-type lectin domain family 7 member A isoform X1. (247 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC112063002Heat shock protein 90-like. (498 aa)
LOC114485589Tyrosine-protein kinase receptor. (513 aa)
ASLArgininosuccinate lyase. (464 aa)
AGXT2Alanine--glyoxylate aminotransferase 2, mitochondrial isoform X2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (513 aa)
DDAH2N(G),N(G)-dimethylarginine dimethylaminohydrolase 2. (285 aa)
ENSPCTP00005015321LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like. (119 aa)
ASS1Argininosuccinate synthase. (154 aa)
MMP8Neutrophil collagenase. (470 aa)
KLF2Krueppel-like factor 2. (355 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
PTX3Pentraxin-related protein PTX3. (382 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PKD2Polycystin-2. (970 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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