node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGXT2 | DDAH2 | ENSPCTP00005017536 | ENSPCTP00005016318 | Alanine--glyoxylate aminotransferase 2, mitochondrial isoform X2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | N(G),N(G)-dimethylarginine dimethylaminohydrolase 2. | 0.665 |
ASL | ASS1 | ENSPCTP00005019146 | ENSPCTP00005013304 | Argininosuccinate lyase. | Argininosuccinate synthase. | 0.999 |
ASS1 | ASL | ENSPCTP00005013304 | ENSPCTP00005019146 | Argininosuccinate synthase. | Argininosuccinate lyase. | 0.999 |
CLEC7A | IFNG | ENSPCTP00005030182 | ENSPCTP00005004159 | C-type lectin domain family 7 member A isoform X1. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.517 |
CLEC7A | IL1B | ENSPCTP00005030182 | ENSPCTP00005010805 | C-type lectin domain family 7 member A isoform X1. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.539 |
DDAH2 | AGXT2 | ENSPCTP00005016318 | ENSPCTP00005017536 | N(G),N(G)-dimethylarginine dimethylaminohydrolase 2. | Alanine--glyoxylate aminotransferase 2, mitochondrial isoform X2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.665 |
ENSPCTP00005015321 | ESR1 | ENSPCTP00005015321 | ENSPCTP00005008502 | LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.660 |
ENSPCTP00005015321 | LOC112063002 | ENSPCTP00005015321 | ENSPCTP00005022743 | LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like. | Heat shock protein 90-like. | 0.899 |
ESR1 | ENSPCTP00005015321 | ENSPCTP00005008502 | ENSPCTP00005015321 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like. | 0.660 |
ESR1 | HSP90AA1 | ENSPCTP00005008502 | ENSPCTP00005030738 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Heat shock protein HSP 90-alpha. | 0.660 |
ESR1 | IFNG | ENSPCTP00005008502 | ENSPCTP00005004159 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | 0.431 |
ESR1 | IL1B | ENSPCTP00005008502 | ENSPCTP00005010805 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.441 |
ESR1 | INSR | ENSPCTP00005008502 | ENSPCTP00005015665 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Insulin receptor isoform X1. | 0.573 |
ESR1 | LOC112063002 | ENSPCTP00005008502 | ENSPCTP00005022743 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Heat shock protein 90-like. | 0.660 |
ESR1 | LOC114485589 | ENSPCTP00005008502 | ENSPCTP00005021675 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Tyrosine-protein kinase receptor. | 0.573 |
ESR1 | SMAD3 | ENSPCTP00005008502 | ENSPCTP00005025310 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Mothers against decapentaplegic homolog. | 0.581 |
HSP90AA1 | ESR1 | ENSPCTP00005030738 | ENSPCTP00005008502 | Heat shock protein HSP 90-alpha. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.660 |
IFNG | CLEC7A | ENSPCTP00005004159 | ENSPCTP00005030182 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | C-type lectin domain family 7 member A isoform X1. | 0.517 |
IFNG | ESR1 | ENSPCTP00005004159 | ENSPCTP00005008502 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.431 |
IFNG | IL1B | ENSPCTP00005004159 | ENSPCTP00005010805 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.922 |