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KDM1A KDM1A DUS1L DUS1L ENSPCTP00005026322 ENSPCTP00005026322 ACAD8 ACAD8 CYBB CYBB XK XK SMIM24 SMIM24 DAO DAO POR POR KDM1B KDM1B NOS1 NOS1 FDXR FDXR ACOX2 ACOX2 SQOR SQOR ACOX3 ACOX3 CRY2 CRY2 DUS2 DUS2 LOC102985122 LOC102985122 PYROXD1 PYROXD1 D2HGDH D2HGDH ENSPCTP00005021029 ENSPCTP00005021029 AIFM1 AIFM1 ENSPCTP00005020713 ENSPCTP00005020713 ACADVL ACADVL ENSPCTP00005020465 ENSPCTP00005020465 ERO1B ERO1B AIFM2 AIFM2 NOS3 NOS3 LOC102996126 LOC102996126 DUS3L DUS3L AIFM3 AIFM3 LOC102986555 LOC102986555 LDHD LDHD MICAL1 MICAL1 PRODH2 PRODH2 PCYOX1 PCYOX1 MICAL2 MICAL2 DDO DDO ACADS ACADS TXNRD2 TXNRD2 XDH XDH NQO2 NQO2 ACAD10 ACAD10 SQLE SQLE ACADL ACADL NDOR1 NDOR1 ILVBL ILVBL ACOX1 ACOX1 NOS2 NOS2 CRY1 CRY1 CYB5R2 CYB5R2 ACADSB ACADSB ENSPCTP00005006191 ENSPCTP00005006191 FMO3 FMO3 DLD DLD AGPS AGPS DUS4L DUS4L MICAL3 MICAL3 ENSPCTP00005004439 ENSPCTP00005004439 LOC102993801 LOC102993801 ENSPCTP00005003817 ENSPCTP00005003817 MTRR MTRR KMO KMO STEAP4 STEAP4 AOX1 AOX1 SDHA SDHA ACAD11 ACAD11 DHCR24 DHCR24 ERO1A ERO1A PIPOX PIPOX CHDH CHDH MTO1 MTO1 CYB5R3 CYB5R3 COQ6 COQ6 ACAD9 ACAD9 MMACHC MMACHC GFER GFER FOXRED2 FOXRED2 MAOB MAOB MTHFR MTHFR GSR GSR FMO4 FMO4 FMO1 FMO1 FMO2 FMO2 ETFA ETFA CYB5R1 CYB5R1 GCDH GCDH TXNRD3 TXNRD3 ACADM ACADM QSOX1 QSOX1 TXNRD1 TXNRD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (878 aa)
DUS1LtRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like. (475 aa)
ENSPCTP00005026322annotation not available (292 aa)
ACAD8isobutyryl-CoA dehydrogenase, mitochondrial isoform X2. (415 aa)
CYBBCytochrome b-245 heavy chain. (570 aa)
XKXK-related protein. (444 aa)
SMIM24Small integral membrane protein 24. (125 aa)
DAOD-amino-acid oxidase. (347 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (681 aa)
KDM1BLysine-specific histone demethylase 1B isoform X1. (821 aa)
NOS1Nitric oxide synthase, brain. (1185 aa)
FDXRNADPH:adrenodoxin oxidoreductase, mitochondrial. (522 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (678 aa)
SQORSulfide:quinone oxidoreductase, mitochondrial isoform X2. (450 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (699 aa)
CRY2Cryptochrome-2. (614 aa)
DUS2tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1. (493 aa)
LOC102985122Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
PYROXD1Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1. (502 aa)
D2HGDHD-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1. (543 aa)
ENSPCTP00005021029annotation not available (275 aa)
AIFM1Apoptosis-inducing factor 1, mitochondrial isoform X1. (613 aa)
ENSPCTP00005020713annotation not available (496 aa)
ACADVLVery long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X2. (677 aa)
ENSPCTP00005020465annotation not available (73 aa)
ERO1BERO1-like protein beta isoform X5. (467 aa)
AIFM2Apoptosis-inducing factor 2 isoform X2. (384 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1200 aa)
LOC102996126Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (600 aa)
DUS3LtRNA-dihydrouridine(47) synthase [NAD(P)(+)]. (650 aa)
AIFM3Apoptosis-inducing factor 3 isoform X3. (605 aa)
LOC102986555isovaleryl-CoA dehydrogenase, mitochondrial. (113 aa)
LDHDProbable D-lactate dehydrogenase, mitochondrial isoform X1. (484 aa)
MICAL1F-actin-monooxygenase MICAL1 isoform X2. (1066 aa)
PRODH2Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (460 aa)
PCYOX1Prenylcysteine oxidase 1. (525 aa)
MICAL2F-actin-monooxygenase MICAL2 isoform X2. (1944 aa)
DDOD-aspartate oxidase isoform X1. (369 aa)
ACADSShort-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1. (386 aa)
TXNRD2Thioredoxin reductase 2, mitochondrial. (281 aa)
XDHXanthine dehydrogenase/oxidase. (219 aa)
NQO2Ribosyldihydronicotinamide dehydrogenase [quinone] isoform X1. (231 aa)
ACAD10LOW QUALITY PROTEIN: acyl-CoA dehydrogenase family member 10. (661 aa)
SQLESqualene monooxygenase. (574 aa)
ACADLLong-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1. (430 aa)
NDOR1NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (604 aa)
ILVBLAcetolactate synthase-like protein isoform X1; Belongs to the TPP enzyme family. (632 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1150 aa)
CRY1Cryptochrome-1 isoform X1. (587 aa)
CYB5R2Cytochrome b5 reductase 2. (268 aa)
ACADSBShort/branched chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1. (432 aa)
ENSPCTP00005006191annotation not available (69 aa)
FMO3Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
DLDDihydrolipoyl dehydrogenase. (509 aa)
AGPSAlkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (659 aa)
DUS4LtRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family. (316 aa)
MICAL3F-actin-monooxygenase MICAL3 isoform X16. (1073 aa)
ENSPCTP00005004439annotation not available (80 aa)
LOC102993801Cytochrome b5 reductase 4 isoform X1. (515 aa)
ENSPCTP00005003817annotation not available (546 aa)
MTRRMethionine synthase reductase isoform X5. (697 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (486 aa)
STEAP4Metalloreductase STEAP4. (458 aa)
AOX1Aldehyde oxidase. (1338 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (665 aa)
ACAD11acyl-CoA dehydrogenase family member 11 isoform X1. (781 aa)
DHCR24Delta(24)-sterol reductase. (516 aa)
ERO1AERO1-like protein alpha isoform X2. (468 aa)
PIPOXPeroxisomal sarcosine oxidase. (390 aa)
CHDHCholine dehydrogenase. (592 aa)
MTO1Protein MTO1 homolog, mitochondrial isoform X1. (692 aa)
CYB5R3NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (343 aa)
COQ6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (469 aa)
ACAD9acyl-CoA dehydrogenase family member 9, mitochondrial isoform X1. (621 aa)
MMACHCMethylmalonic aciduria and homocystinuria type C protein isoform X1. (280 aa)
GFERSulfhydryl oxidase. (206 aa)
FOXRED2FAD-dependent oxidoreductase domain-containing protein 2 isoform X1. (687 aa)
MAOBAmine oxidase. (520 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (696 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (519 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (571 aa)
FMO1Dimethylaniline monooxygenase [N-oxide-forming]. (120 aa)
FMO2Flavin-containing monooxygenase. (498 aa)
ETFAElectron transfer flavoprotein subunit alpha, mitochondrial isoform X1. (333 aa)
CYB5R1NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
GCDHglutaryl-CoA dehydrogenase, mitochondrial isoform X2. (438 aa)
TXNRD3LOW QUALITY PROTEIN: thioredoxin reductase 3. (611 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial. (454 aa)
QSOX1Sulfhydryl oxidase. (754 aa)
TXNRD1Thioredoxin reductase 1, cytoplasmic isoform X3. (565 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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