STRINGSTRING
DACH1 DACH1 AR AR NRARP NRARP XBP1 XBP1 SDR16C5 SDR16C5 MEF2C MEF2C FGL1 FGL1 FST FST ESR1 ESR1 STK3 STK3 KDR KDR PTCH1 PTCH1 HGF HGF HMX2 HMX2 TNFSF11 TNFSF11 AREG AREG EREG EREG COL8A2 COL8A2 ENSPCTP00005017372 ENSPCTP00005017372 NOG NOG PHOX2B PHOX2B CCND1 CCND1 BMP4 BMP4 PPARD PPARD CD109 CD109 WNT5A WNT5A IFT52 IFT52 CEBPB CEBPB IRF6 IRF6 EPHA2 EPHA2 DRD2 DRD2 STK11 STK11 AGAP2 AGAP2 LOC112066930 LOC112066930 ENSPCTP00005028784 ENSPCTP00005028784 IGFBP4 IGFBP4 LIPA LIPA FGF10 FGF10 C18H6orf89 C18H6orf89 TBX2 TBX2 PHB2 PHB2 GPC3 GPC3 LOC102985790 LOC102985790 CDKN1B CDKN1B IRS2 IRS2 CTNNB1 CTNNB1 PURA PURA APOA1 APOA1 LOC102987670 LOC102987670 BTRC BTRC STAT6 STAT6 TEK TEK SIDT2 SIDT2 CDH13 CDH13 RB1 RB1 MAP2K1 MAP2K1 IFT74 IFT74 ST8SIA1 ST8SIA1 TGFB1 TGFB1 SFN SFN PSEN1 PSEN1 KDF1 KDF1 NOTCH2 NOTCH2 IQGAP3 IQGAP3 HSF4 HSF4 NKX3-1 NKX3-1 SCARB1 SCARB1 CCL5 CCL5 BCL2L2 BCL2L2 LOXL2 LOXL2 BAD BAD LOC112063307 LOC112063307 FSHR FSHR COL8A1 COL8A1 FOXE3 FOXE3 STK4 STK4 SAV1 SAV1 BAK1 BAK1 LOC102995227 LOC102995227 MAPK1 MAPK1 MKI67 MKI67 ID2 ID2 PDX1 PDX1 LOC114487773 LOC114487773 FAP FAP FGF7 FGF7 EYA1 EYA1 TP63 TP63 ENSPCTP00005010780 ENSPCTP00005010780 MED1 MED1 SHH SHH BMPR1A BMPR1A ENSPCTP00005011984 ENSPCTP00005011984 NF1 NF1 FGF9 FGF9 PROK2 PROK2 NOTCH1 NOTCH1 LOC112064339 LOC112064339 FERMT1 FERMT1 LOC114486175 LOC114486175 DLG2 DLG2 FGF2 FGF2 YAP1 YAP1 MTA3 MTA3 MTSS1 MTSS1 EAF2 EAF2 OVOL1 OVOL1 SOX9 SOX9 RUNX2 RUNX2 LGR5 LGR5 VSTM4 VSTM4 PRKX PRKX ENSPCTP00005015662 ENSPCTP00005015662 WNT2 WNT2 PROK1 PROK1 PROX1 PROX1 BMPR2 BMPR2 ZEB1 ZEB1 BMPER BMPER EGF EGF DLG1 DLG1 WNT16 WNT16 IFT57 IFT57 HLX HLX IL6 IL6 RETNLB RETNLB TRIM24 TRIM24 WDR77 WDR77 NCSTN NCSTN B4GALT1 B4GALT1 FGF1 FGF1 LIMS2 LIMS2 SMO SMO IGFBP3 IGFBP3 NKX2-6 NKX2-6 CAV2 CAV2 CAV1 CAV1 IFT80 IFT80 A4GNT A4GNT TGFA TGFA LGR4 LGR4 ITGB1BP1 ITGB1BP1 SERPINF1 SERPINF1 NKX2-8 NKX2-8 TGFBR1 TGFBR1 EHF EHF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DACH1Dachshund homolog 1. (761 aa)
ARAndrogen receptor isoform X1. (892 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (379 aa)
SDR16C5Epidermal retinol dehydrogenase 2 isoform X2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (330 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (483 aa)
FGL1Fibrinogen-like protein 1 isoform X1. (312 aa)
FSTFollistatin isoform X1. (344 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
STK3Serine/threonine-protein kinase 3 isoform X2. (491 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PTCH1Protein patched homolog 1. (1449 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
HMX2Homeobox protein HMX2. (274 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (318 aa)
AREGAmphiregulin isoform X1. (275 aa)
EREGProepiregulin. (223 aa)
COL8A2Collagen alpha-2(VIII) chain. (705 aa)
ENSPCTP00005017372annotation not available (232 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (314 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
CD109CD109 antigen isoform X1. (1440 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (446 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
IRF6Interferon regulatory factor 6 isoform X1. (473 aa)
EPHA2Ephrin type-A receptor 2 isoform X2. (964 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (443 aa)
STK11Serine/threonine-protein kinase STK11 isoform X4; Belongs to the protein kinase superfamily. (437 aa)
AGAP2arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2. (1196 aa)
LOC112066930THAP domain-containing protein 1-like. (209 aa)
ENSPCTP00005028784THAP domain-containing protein 1-like. (214 aa)
IGFBP4Insulin-like growth factor-binding protein 4. (258 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
C18H6orf89Bombesin receptor-activated protein C6orf89 homolog isoform X1. (355 aa)
TBX2T-box transcription factor TBX2. (712 aa)
PHB2Prohibitin. (299 aa)
GPC3Glypican-3 isoform X1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
LOC102985790Kallikrein-8. (145 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
IRS2Insulin receptor substrate 2 isoform X1. (1370 aa)
CTNNB1Catenin beta-1. (783 aa)
PURATranscriptional activator protein Pur-alpha. (323 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). (265 aa)
LOC102987670Serine/threonine-protein kinase/endoribonuclease IRE1. (931 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X3. (605 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
SIDT2SID1 transmembrane family member 2 isoform X2. (835 aa)
CDH13Cadherin-13 isoform X1. (713 aa)
RB1Retinoblastoma-associated protein isoform X2. (929 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IFT74Intraflagellar transport protein 74 homolog isoform X1. (600 aa)
ST8SIA1alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; Belongs to the glycosyltransferase 29 family. (356 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (464 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2471 aa)
IQGAP3Ras GTPase-activating-like protein IQGAP3. (1126 aa)
HSF4Heat shock factor protein 4 isoform X6. (490 aa)
NKX3-1Homeobox protein Nkx-3.1. (158 aa)
SCARB1Scavenger receptor class B member 1 isoform X2; Belongs to the CD36 family. (509 aa)
CCL5C-C motif chemokine. (91 aa)
BCL2L2Bcl-2-like protein 2 isoform X2. (193 aa)
LOXL2Lysyl oxidase homolog 2. (786 aa)
BADBcl2-associated agonist of cell death. (168 aa)
LOC112063307Leukocyte elastase inhibitor-like; Belongs to the serpin family. (79 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
COL8A1Collagen alpha-1(VIII) chain. (744 aa)
FOXE3Forkhead box protein E3. (318 aa)
STK4Serine/threonine-protein kinase 4. (448 aa)
SAV1Protein salvador homolog 1. (384 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
LOC102995227Folliculin isoform X1. (478 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
MKI67Proliferation marker protein Ki-67 isoform X1. (3097 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
PDX1Pancreas/duodenum homeobox protein 1. (283 aa)
LOC114487773Serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1. (106 aa)
FAPProlyl endopeptidase FAP isoform X1; Belongs to the peptidase S9B family. (760 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ENSPCTP00005010780annotation not available (140 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (452 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (482 aa)
ENSPCTP00005011984annotation not available (66 aa)
NF1Neurofibromin isoform X3. (2860 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PROK2Prokineticin-2 isoform X1. (129 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2531 aa)
LOC112064339Leukocyte elastase inhibitor-like; Belongs to the serpin family. (592 aa)
FERMT1Fermitin family homolog 1 isoform X1. (677 aa)
LOC114486175Ras GTPase-activating-like protein IQGAP3 isoform X2. (479 aa)
DLG2Disks large homolog 2 isoform X2. (904 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
YAP1Transcriptional coactivator YAP1 isoform X2. (509 aa)
MTA3Metastasis-associated protein MTA3. (594 aa)
MTSS1Metastasis suppressor protein 1 isoform X5. (760 aa)
EAF2ELL-associated factor 2. (264 aa)
OVOL1Putative transcription factor Ovo-like 1. (267 aa)
SOX9Transcription factor SOX-9. (501 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (529 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1. (907 aa)
VSTM4V-set and transmembrane domain-containing protein 4 isoform X2. (171 aa)
PRKXcAMP-dependent protein kinase catalytic subunit PRKX; Belongs to the protein kinase superfamily. (358 aa)
ENSPCTP00005015662annotation not available (82 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
PROK1Prokineticin-1. (105 aa)
PROX1Prospero homeobox protein 1 isoform X1. (737 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1049 aa)
ZEB1Zinc finger E-box-binding homeobox 1 isoform X2. (1125 aa)
BMPERBMP-binding endothelial regulator protein. (685 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1206 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
IFT57Intraflagellar transport protein 57 homolog. (427 aa)
HLXH2.0-like homeobox protein. (489 aa)
IL6Interleukin-6. (208 aa)
RETNLBResistin-like beta. (112 aa)
TRIM24Transcription intermediary factor 1-alpha isoform X1. (1052 aa)
WDR77Methylosome protein 50 isoform X1. (342 aa)
NCSTNNicastrin isoform X2. (709 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (404 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (366 aa)
SMOSmoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
IGFBP3Insulin-like growth factor-binding protein 3. (299 aa)
NKX2-6Homeobox protein Nkx-2.6. (301 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
IFT80Intraflagellar transport protein 80 homolog. (777 aa)
A4GNTalpha-1,4-N-acetylglucosaminyltransferase. (341 aa)
TGFAProtransforming growth factor alpha isoform X1. (160 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X2. (198 aa)
SERPINF1Pigment epithelium-derived factor; Belongs to the serpin family. (437 aa)
NKX2-8Homeobox protein Nkx-2.8. (235 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (513 aa)
EHFETS homologous factor isoform X1. (300 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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