(52 nodes) Cardiac septum morphogenesis network (Physeter catodon)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ISL1	Insulin gene enhancer protein ISL-1. (349 aa)
	ENG	Endoglin isoform X1. (655 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (482 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	NSD2	Histone-lysine N-methyltransferase NSD2 isoform X3. (1359 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (931 aa)
	ENSPCTP00005008487	annotation not available (114 aa)
	CHD7	chromodomain-helicase-DNA-binding protein 7 isoform X1. (1134 aa)
	ZFPM1	Zinc finger protein ZFPM1. (147 aa)
	SEMA3C	semaphorin-3C isoform X1; Belongs to the semaphorin family. (777 aa)
	RBM15	RNA-binding protein 15. (969 aa)
	PROX1	Prospero homeobox protein 1 isoform X1. (737 aa)
	LRP2	Low-density lipoprotein receptor-related protein 2. (4650 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1049 aa)
	GATA4	Transcription factor GATA-4. (208 aa)
	DNAH11	LOW QUALITY PROTEIN: dynein heavy chain 11, axonemal. (4522 aa)
	NKX2-5	Homeobox protein Nkx-2.5. (323 aa)
	TBX20	T-box transcription factor TBX20. (449 aa)
	CITED2	Cbp/p300-interacting transactivator 2. (281 aa)
	HAND1	Heart- and neural crest derivatives-expressed protein 1. (218 aa)
	SLIT3	Slit homolog 3 protein. (1530 aa)
	HES1	Transcription factor HES-1. (280 aa)
	MKS1	Meckel syndrome type 1 protein isoform X3. (559 aa)
	CCN1	Protein CYR61. (382 aa)
	PARVA	Alpha-parvin isoform X2. (452 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (513 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1. (2531 aa)
	HEY2	Hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1. (337 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)
	GATA6	Transcription factor GATA-6. (592 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
	TBX2	T-box transcription factor TBX2. (712 aa)
	ZFPM2	Zinc finger protein ZFPM2. (1151 aa)
	BMP7	Bone morphogenetic protein 7 isoform X1. (431 aa)
	TBX3	T-box transcription factor TBX3 isoform X1. (745 aa)
	SMAD6	Mothers against decapentaplegic homolog. (495 aa)
	LOC102982778	Transcription factor GATA-4. (229 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2. (2471 aa)
	TBX5	T-box transcription factor TBX5. (519 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	SAV1	Protein salvador homolog 1. (384 aa)
	SMAD4	Mothers against decapentaplegic homolog. (553 aa)
	FZD2	Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
	ENSPCTP00005017372	annotation not available (232 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	EGLN1	Egl nine homolog 1 isoform X1. (437 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	SMO	Smoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
	HEYL	Hairy/enhancer-of-split related with YRPW motif-like protein isoform X2. (323 aa)
	DHRS3	Short-chain dehydrogenase/reductase 3 isoform X2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)

Your Current Organism:

Physeter catodon

NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMP7	ENSPCTP00005031951	ENSPCTP00005027674	Bone morphogenetic protein 4.	Bone morphogenetic protein 7 isoform X1.	0.808
BMP4	BMPR1A	ENSPCTP00005031951	ENSPCTP00005010638	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.963
BMP4	BMPR2	ENSPCTP00005031951	ENSPCTP00005004973	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.992
BMP4	ENSPCTP00005017372	ENSPCTP00005031951	ENSPCTP00005017372	Bone morphogenetic protein 4.	annotation not available	0.910
BMP4	FGF8	ENSPCTP00005031951	ENSPCTP00005021520	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.589
BMP4	GATA4	ENSPCTP00005031951	ENSPCTP00005003907	Bone morphogenetic protein 4.	Transcription factor GATA-4.	0.579
BMP4	GATA6	ENSPCTP00005031951	ENSPCTP00005030582	Bone morphogenetic protein 4.	Transcription factor GATA-6.	0.603
BMP4	ISL1	ENSPCTP00005031951	ENSPCTP00005029107	Bone morphogenetic protein 4.	Insulin gene enhancer protein ISL-1.	0.518
BMP4	JAG1	ENSPCTP00005031951	ENSPCTP00005009660	Bone morphogenetic protein 4.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.641
BMP4	LOC102982778	ENSPCTP00005031951	ENSPCTP00005024108	Bone morphogenetic protein 4.	Transcription factor GATA-4.	0.579
BMP4	NKX2-5	ENSPCTP00005031951	ENSPCTP00005003823	Bone morphogenetic protein 4.	Homeobox protein Nkx-2.5.	0.440
BMP4	NOG	ENSPCTP00005031951	ENSPCTP00005017349	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.990
BMP4	NOTCH1	ENSPCTP00005031951	ENSPCTP00005013162	Bone morphogenetic protein 4.	Neurogenic locus notch homolog protein 1.	0.403
BMP4	SMAD4	ENSPCTP00005031951	ENSPCTP00005019284	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.874
BMP4	SMAD6	ENSPCTP00005031951	ENSPCTP00005025181	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.731
BMP4	SMAD7	ENSPCTP00005031951	ENSPCTP00005030907	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.714
BMP4	TBX3	ENSPCTP00005031951	ENSPCTP00005027392	Bone morphogenetic protein 4.	T-box transcription factor TBX3 isoform X1.	0.478
BMP4	TBX5	ENSPCTP00005031951	ENSPCTP00005021617	Bone morphogenetic protein 4.	T-box transcription factor TBX5.	0.521
BMP4	TGFBR1	ENSPCTP00005031951	ENSPCTP00005014909	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.778
BMP4	WNT11	ENSPCTP00005031951	ENSPCTP00005016456	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.431