STRINGSTRING
HADH HADH HPGD HPGD SIRT1 SIRT1 SIRT5 SIRT5 PARP14 PARP14 EHHADH EHHADH ENSPCTP00005012060 ENSPCTP00005012060 ENSPCTP00005012089 ENSPCTP00005012089 CRYL1 CRYL1 SIRT2 SIRT2 ALDH1A3 ALDH1A3 UXS1 UXS1 SIRT6 SIRT6 LOC114485288 LOC114485288 LOC102992890 LOC102992890 SIRT4 SIRT4 SIRT7 SIRT7 HADHA HADHA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HADHHydroxyacyl-coenzyme A dehydrogenase, mitochondrial. (314 aa)
HPGD15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (731 aa)
SIRT5Sirtuin 5. (336 aa)
PARP14Poly [ADP-ribose] polymerase. (1798 aa)
EHHADHPeroxisomal bifunctional enzyme isoform X1. (723 aa)
ENSPCTP00005012060annotation not available (77 aa)
ENSPCTP00005012089annotation not available (77 aa)
CRYL1Lambda-crystallin homolog. (483 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (426 aa)
ALDH1A3Aldehyde dehydrogenase family 1 member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
UXS1UDP-glucuronic acid decarboxylase 1 isoform X1. (425 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X1. (359 aa)
LOC114485288NAD-dependent protein deacetylase sirtuin-3, mitochondrial-like. (164 aa)
LOC102992890NAD-dependent protein deacetylase sirtuin-3. (172 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7 isoform X1. (420 aa)
HADHATrifunctional enzyme subunit alpha, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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