(18 nodes) Phosphatidylinositol 3-/4-kinase, catalytic domain network (Physeter catodon)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:
	ATR	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
	PIK3CG	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1102 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1100 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
	PI4K2B	Phosphatidylinositol 4-kinase type 2-beta isoform X1. (551 aa)
	TRRAP	Transformation/transcription domain-associated protein isoform X5; Belongs to the PI3/PI4-kinase family. (3860 aa)
	LOC102989189	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (158 aa)
	PI4KA	Phosphatidylinositol 4-kinase alpha isoform X1; Belongs to the PI3/PI4-kinase family. (1305 aa)
	PI4K2A	Phosphatidylinositol 4-kinase type 2-alpha. (479 aa)
	PIK3C2A	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Belongs to the PI3/PI4-kinase family. (1689 aa)
	PIK3C2B	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X9; Belongs to the PI3/PI4-kinase family. (1634 aa)
	PRKDC	DNA-dependent protein kinase catalytic subunit isoform X1; Belongs to the PI3/PI4-kinase family. (4147 aa)
	PIK3C2G	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1; Belongs to the PI3/PI4-kinase family. (1483 aa)
	SMG1	Serine/threonine-protein kinase SMG1 isoform X1; Belongs to the PI3/PI4-kinase family. (3658 aa)

Your Current Organism:

Physeter catodon

NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSPCTP00005007292	ENSPCTP00005000139	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	0.999
ATM	MTOR	ENSPCTP00005007292	ENSPCTP00005003871	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.540
ATM	PRKDC	ENSPCTP00005007292	ENSPCTP00005023661	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA-dependent protein kinase catalytic subunit isoform X1; Belongs to the PI3/PI4-kinase family.	0.702
ATM	SMG1	ENSPCTP00005007292	ENSPCTP00005031367	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase SMG1 isoform X1; Belongs to the PI3/PI4-kinase family.	0.585
ATM	TRRAP	ENSPCTP00005007292	ENSPCTP00005016987	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Transformation/transcription domain-associated protein isoform X5; Belongs to the PI3/PI4-kinase family.	0.431
ATR	ATM	ENSPCTP00005000139	ENSPCTP00005007292	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.999
LOC102989189	PI4K2A	ENSPCTP00005027114	ENSPCTP00005018954	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase type 2-alpha.	0.470
LOC102989189	PI4K2B	ENSPCTP00005027114	ENSPCTP00005015518	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase type 2-beta isoform X1.	0.462
LOC102989189	PI4KA	ENSPCTP00005027114	ENSPCTP00005025054	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase alpha isoform X1; Belongs to the PI3/PI4-kinase family.	0.544
MTOR	ATM	ENSPCTP00005003871	ENSPCTP00005007292	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.540
MTOR	PIK3CA	ENSPCTP00005003871	ENSPCTP00005003548	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.931
MTOR	PIK3CB	ENSPCTP00005003871	ENSPCTP00005000178	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	0.931
MTOR	PIK3CG	ENSPCTP00005003871	ENSPCTP00005004726	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family.	0.426
MTOR	TRRAP	ENSPCTP00005003871	ENSPCTP00005016987	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Transformation/transcription domain-associated protein isoform X5; Belongs to the PI3/PI4-kinase family.	0.617
PI4K2A	LOC102989189	ENSPCTP00005018954	ENSPCTP00005027114	Phosphatidylinositol 4-kinase type 2-alpha.	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	0.470
PI4K2A	PI4K2B	ENSPCTP00005018954	ENSPCTP00005015518	Phosphatidylinositol 4-kinase type 2-alpha.	Phosphatidylinositol 4-kinase type 2-beta isoform X1.	0.902
PI4K2A	PI4KA	ENSPCTP00005018954	ENSPCTP00005025054	Phosphatidylinositol 4-kinase type 2-alpha.	Phosphatidylinositol 4-kinase alpha isoform X1; Belongs to the PI3/PI4-kinase family.	0.977
PI4K2A	PIK3C2A	ENSPCTP00005018954	ENSPCTP00005020986	Phosphatidylinositol 4-kinase type 2-alpha.	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Belongs to the PI3/PI4-kinase family.	0.933
PI4K2A	PIK3C2G	ENSPCTP00005018954	ENSPCTP00005018239	Phosphatidylinositol 4-kinase type 2-alpha.	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1; Belongs to the PI3/PI4-kinase family.	0.906
PI4K2A	PIK3C3	ENSPCTP00005018954	ENSPCTP00005010658	Phosphatidylinositol 4-kinase type 2-alpha.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.922