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PLCG1 PLCG1 TNS2 TNS2 SHE SHE SH2D6 SH2D6 SHC1 SHC1 RASA1 RASA1 PTPN11 PTPN11 SH2D1A SH2D1A SOCS5 SOCS5 LCK LCK SYK SYK SOCS6 SOCS6 TNS4 TNS4 SOCS1 SOCS1 SH2B2 SH2B2 SHC3 SHC3 STAT3 STAT3 STAT5A STAT5A SH2D2A SH2D2A STAT5B STAT5B SH2D3C SH2D3C ABL1 ABL1 ZAP70 ZAP70 TXK TXK TEC TEC GRB7 GRB7 SRMS SRMS HSH2D HSH2D CRK CRK ABL2 ABL2 MATK MATK PLCG2 PLCG2 SHF SHF YES1 YES1 SH2D5 SH2D5 PIK3R3 PIK3R3 PTK6 PTK6 STAT6 STAT6 TNS1 TNS1 CRKL CRKL BLK BLK CISH CISH SH3BP2 SH3BP2 CLNK CLNK SLA SLA SH2B3 SH2B3 INPP5D INPP5D FER FER STAT1 STAT1 STAT4 STAT4 PTPN6 PTPN6 INPPL1 INPPL1 SH2D4A SH2D4A SH2B1 SH2B1 SH2D7 SH2D7 SHC2 SHC2 PIK3R2 PIK3R2 JAK3 JAK3 SUPT6H SUPT6H SOCS2 SOCS2 TYK2 TYK2 SOCS3 SOCS3 BLNK BLNK JAK1 JAK1 SOCS4 SOCS4 LYN LYN CHN1 CHN1 LOC102981784 LOC102981784 SH2D4B SH2D4B BTK BTK NCK1 NCK1 GRB14 GRB14 VAV3 VAV3 FES FES STAP1 STAP1 BMX BMX GRB10 GRB10 LCP2 LCP2 ITK ITK LOC102987506 LOC102987506 VAV2 VAV2 DAPP1 DAPP1 SRC SRC SH2D1B SH2D1B SOCS7 SOCS7 JAK2 JAK2 CHN2 CHN2 FGR FGR CSK CSK SHD SHD FYN FYN STAT2 STAT2 SLA2 SLA2 PIK3R1 PIK3R1 SHB SHB FRK FRK HCK HCK NCK2 NCK2 SHC4 SHC4 SH2D3A SH2D3A BCAR3 BCAR3 VAV1 VAV1 RIN1 RIN1 GRAP2 GRAP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1165 aa)
TNS2Tensin-2 isoform X4. (1409 aa)
SHESH2 domain-containing adapter protein E isoform X1. (498 aa)
SH2D6SH2 domain-containing protein 6-like. (356 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
RASA1Ras GTPase-activating protein 1 isoform X2. (1040 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
SOCS5Suppressor of cytokine signaling 5 isoform X1. (536 aa)
LCKTyrosine-protein kinase. (539 aa)
SYKTyrosine-protein kinase. (627 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
TNS4Tensin-4 isoform X2. (677 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
SH2B2SH2B adapter protein 2 isoform X1. (639 aa)
SHC3SHC-transforming protein 3. (584 aa)
STAT3Signal transducer and activator of transcription. (801 aa)
STAT5ASignal transducer and activator of transcription. (739 aa)
SH2D2ASH2 domain-containing protein 2A isoform X3. (365 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
SH2D3CSH2 domain-containing protein 3C. (851 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
ZAP70Tyrosine-protein kinase. (617 aa)
TXKTyrosine-protein kinase. (525 aa)
TECTyrosine-protein kinase. (633 aa)
GRB7Growth factor receptor-bound protein 7 isoform X9. (532 aa)
SRMSTyrosine-protein kinase. (486 aa)
HSH2DHematopoietic SH2 domain-containing protein. (345 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
ABL2Tyrosine-protein kinase. (1071 aa)
MATKTyrosine-protein kinase. (495 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
SHFSH2 domain-containing adapter protein F. (241 aa)
YES1Tyrosine-protein kinase. (543 aa)
SH2D5SH2 domain-containing protein 5. (428 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PTK6Tyrosine-protein kinase. (122 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
TNS1Tensin-1 isoform X8. (1893 aa)
CRKLCrk-like protein. (279 aa)
BLKTyrosine-protein kinase. (434 aa)
CISHCytokine-inducible SH2-containing protein. (254 aa)
SH3BP2SH3 domain-binding protein 2 isoform X4. (619 aa)
CLNKLOW QUALITY PROTEIN: cytokine-dependent hematopoietic cell linker. (424 aa)
SLASrc-like-adapter isoform X2. (314 aa)
SH2B3SH2B adapter protein 3 isoform X4. (570 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1180 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1264 aa)
SH2D4ASH2 domain-containing protein 4A. (450 aa)
SH2B1SH2B adapter protein 1 isoform X2. (757 aa)
SH2D7SH2 domain-containing protein 7. (447 aa)
SHC2SHC-transforming protein 2. (171 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1722 aa)
SOCS2Suppressor of cytokine signaling 2. (225 aa)
TYK2Tyrosine-protein kinase. (1185 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
BLNKB-cell linker protein. (459 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
LYNTyrosine-protein kinase. (512 aa)
CHN1Chimaerin; GTPase-activating protein for p21-rac. (459 aa)
LOC102981784GRB2-related adapter protein isoform X2. (217 aa)
SH2D4BSH2 domain-containing protein 4B. (296 aa)
BTKTyrosine-protein kinase. (692 aa)
NCK1Cytoplasmic protein. (377 aa)
GRB14Growth factor receptor-bound protein 14 isoform X1. (540 aa)
VAV3LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV3. (875 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
STAP1LOW QUALITY PROTEIN: signal-transducing adaptor protein 1. (269 aa)
BMXTyrosine-protein kinase. (651 aa)
GRB10Growth factor receptor-bound protein 10 isoform X1. (515 aa)
LCP2Lymphocyte cytosolic protein 2 isoform X2. (533 aa)
ITKTyrosine-protein kinase. (620 aa)
LOC102987506Tyrosine-protein phosphatase non-receptor type 11-like isoform X1. (612 aa)
VAV2Guanine nucleotide exchange factor VAV2. (864 aa)
DAPP1Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X3. (264 aa)
SRCTyrosine-protein kinase. (548 aa)
SH2D1BSH2 domain-containing protein 1B. (132 aa)
SOCS7Suppressor of cytokine signaling 7 isoform X1. (641 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
CHN2Chimaerin; GTPase-activating protein for p21-rac. (468 aa)
FGRTyrosine-protein kinase. (526 aa)
CSKTyrosine-protein kinase. (450 aa)
SHDSH2 domain-containing adapter protein D. (334 aa)
FYNTyrosine-protein kinase. (537 aa)
STAT2Signal transducer and activator of transcription. (903 aa)
SLA2Src-like-adapter 2. (326 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
SHBSH2 domain-containing adapter protein B isoform X4. (511 aa)
FRKTyrosine-protein kinase. (507 aa)
HCKTyrosine-protein kinase. (525 aa)
NCK2Cytoplasmic protein. (375 aa)
SHC4SHC-transforming protein 4 isoform X2. (630 aa)
SH2D3ASH2 domain-containing protein 3A. (577 aa)
BCAR3Breast cancer anti-estrogen resistance protein 3 isoform X2. (606 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
RIN1Ras and Rab interactor 1 isoform X1. (783 aa)
GRAP2GRB2-related adapter protein 2 isoform X1. (316 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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