STRINGSTRING
MERTK MERTK SRC SRC ILK ILK TNK2 TNK2 NTRK2 NTRK2 BMPR1B BMPR1B MAP3K9 MAP3K9 ITK ITK PTK2B PTK2B BRAF BRAF EPHA5 EPHA5 NEK7 NEK7 EGFR EGFR BMX BMX FLT4 FLT4 FES FES EPHA1 EPHA1 MET MET RYK RYK EPHB1 EPHB1 MAP3K13 MAP3K13 ACVR1 ACVR1 ACVR1C ACVR1C TXK TXK TEC TEC BMPR1A BMPR1A SRMS SRMS ERBB2 ERBB2 KSR1 KSR1 LYN LYN FGFR3 FGFR3 AXL AXL BTK BTK RAF1 RAF1 JAK2 JAK2 PDGFRA PDGFRA KIT KIT KDR KDR MAP3K20 MAP3K20 ROR1 ROR1 FYN FYN LOC102990764 LOC102990764 TNK1 TNK1 FGFR1 FGFR1 NPR1 NPR1 EPHB6 EPHB6 VRK3 VRK3 CSK CSK LIMK1 LIMK1 EPHA6 EPHA6 GUCY2F GUCY2F DSTYK DSTYK FGR FGR EPHA3 EPHA3 ABL2 ABL2 PTK2 PTK2 MATK MATK YES1 YES1 ERBB3 ERBB3 KSR2 KSR2 LIMK2 LIMK2 TEK TEK PTK6 PTK6 MAP3K11 MAP3K11 HSD17B7 HSD17B7 TYRO3 TYRO3 TESK1 TESK1 BLK BLK EPHA7 EPHA7 LTK LTK TIE1 TIE1 RET RET FER FER NPR2 NPR2 MAP3K10 MAP3K10 PDGFRB PDGFRB EPHB3 EPHB3 LOC102987472 LOC102987472 MAP3K12 MAP3K12 LOC102989902 LOC102989902 POMK POMK AATK AATK EPHB4 EPHB4 EPHA4 EPHA4 EPHA2 EPHA2 PTK7 PTK7 LOC102988943 LOC102988943 JAK3 JAK3 STYK1 STYK1 LOC102996862 LOC102996862 EPHB2 EPHB2 TYK2 TYK2 FGFR2 FGFR2 NEK6 NEK6 JAK1 JAK1 LOC114485589 LOC114485589 ACVRL1 ACVRL1 TESK2 TESK2 LMTK2 LMTK2 FRK FRK HCK HCK FLT1 FLT1 NRBP1 NRBP1 LOC102982969 LOC102982969 GUCY2D GUCY2D FLT3 FLT3 MUSK MUSK ROS1 ROS1 MAP3K21 MAP3K21 IGF1R IGF1R ROR2 ROR2 LCK LCK SYK SYK LOC114487554 LOC114487554 TGFBR2 TGFBR2 GUCY2C GUCY2C LOC102984527 LOC102984527 RIPK2 RIPK2 NTRK3 NTRK3 INSRR INSRR DDR1 DDR1 NTRK1 NTRK1 RIPK1 RIPK1 ARAF ARAF ABL1 ABL1 MST1R MST1R MAP3K7 MAP3K7 ERBB4 ERBB4 EPHA8 EPHA8 ZAP70 ZAP70
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MERTKTyrosine-protein kinase Mer. (998 aa)
SRCTyrosine-protein kinase. (548 aa)
ILKIntegrin-linked protein kinase. (452 aa)
TNK2Activated CDC42 kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (343 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (531 aa)
MAP3K9Mitogen-activated protein kinase kinase kinase. (1103 aa)
ITKTyrosine-protein kinase. (620 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X2. (802 aa)
EPHA5Ephrin type-A receptor 5 isoform X1. (1037 aa)
NEK7Serine/threonine-protein kinase Nek7 isoform X6; Belongs to the protein kinase superfamily. (336 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
BMXTyrosine-protein kinase. (651 aa)
FLT4Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
EPHA1Ephrin type-A receptor 1. (979 aa)
METHepatocyte growth factor receptor. (1412 aa)
RYKTyrosine-protein kinase RYK isoform X1. (609 aa)
EPHB1Ephrin type-B receptor 1. (984 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
TXKTyrosine-protein kinase. (525 aa)
TECTyrosine-protein kinase. (633 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (482 aa)
SRMSTyrosine-protein kinase. (486 aa)
ERBB2Receptor protein-tyrosine kinase. (1302 aa)
KSR1Kinase suppressor of Ras 1 isoform X3. (828 aa)
LYNTyrosine-protein kinase. (512 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
AXLTyrosine-protein kinase receptor UFO isoform X1. (887 aa)
BTKTyrosine-protein kinase. (692 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20 isoform X2. (954 aa)
ROR1Inactive tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
FYNTyrosine-protein kinase. (537 aa)
LOC102990764Inactive serine/threonine-protein kinase TEX14 isoform X3. (863 aa)
TNK1Non-receptor tyrosine-protein kinase TNK1 isoform X2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (665 aa)
FGFR1Fibroblast growth factor receptor. (852 aa)
NPR1Guanylate cyclase. (1058 aa)
EPHB6Ephrin type-B receptor 6. (1009 aa)
VRK3Inactive serine/threonine-protein kinase VRK3 isoform X5. (419 aa)
CSKTyrosine-protein kinase. (450 aa)
LIMK1LIM domain kinase 1. (628 aa)
EPHA6Ephrin type-A receptor 6 isoform X2. (1129 aa)
GUCY2FGuanylate cyclase. (1108 aa)
DSTYKDual serine/threonine and tyrosine protein kinase isoform X2. (929 aa)
FGRTyrosine-protein kinase. (526 aa)
EPHA3Ephrin type-A receptor 3 isoform X1. (984 aa)
ABL2Tyrosine-protein kinase. (1071 aa)
PTK2Focal adhesion kinase 1 isoform X10; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
MATKTyrosine-protein kinase. (495 aa)
YES1Tyrosine-protein kinase. (543 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
KSR2Kinase suppressor of Ras 2. (950 aa)
LIMK2LIM domain kinase 2 isoform X1. (599 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
PTK6Tyrosine-protein kinase. (122 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (842 aa)
HSD17B7Discoidin domain-containing receptor 2 isoform X2. (855 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3. (890 aa)
TESK1Dual specificity testis-specific protein kinase 1 isoform X1. (628 aa)
BLKTyrosine-protein kinase. (434 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (998 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (464 aa)
TIE1Tyrosine-protein kinase receptor Tie-1 isoform X3. (1139 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1108 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
NPR2Guanylate cyclase. (1047 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (948 aa)
PDGFRBPlatelet-derived growth factor receptor beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1003 aa)
EPHB3Ephrin type-B receptor 3. (997 aa)
LOC102987472Guanylate cyclase. (187 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (900 aa)
LOC102989902Serine/threonine-protein kinase TNNI3K isoform X1. (835 aa)
POMKProtein O-mannose kinase isoform X2. (360 aa)
AATKSerine/threonine-protein kinase LMTK1. (1394 aa)
EPHB4Ephrin type-B receptor 4. (307 aa)
EPHA4Ephrin type-A receptor 4. (986 aa)
EPHA2Ephrin type-A receptor 2 isoform X2. (964 aa)
PTK7Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1043 aa)
LOC102988943Ephrin type-A receptor 10. (155 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
STYK1Tyrosine-protein kinase STYK1 isoform X2. (427 aa)
LOC102996862Receptor protein-tyrosine kinase. (306 aa)
EPHB2Ephrin type-B receptor 2. (691 aa)
TYK2Tyrosine-protein kinase. (1185 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
NEK6Serine/threonine-protein kinase Nek6 isoform X1; Belongs to the protein kinase superfamily. (313 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
LOC114485589Tyrosine-protein kinase receptor. (513 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
TESK2Dual specificity testis-specific protein kinase 2. (357 aa)
LMTK2Serine/threonine-protein kinase LMTK2 isoform X1. (1484 aa)
FRKTyrosine-protein kinase. (507 aa)
HCKTyrosine-protein kinase. (525 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
NRBP1Nuclear receptor-binding protein. (543 aa)
LOC102982969Activated CDC42 kinase 1 isoform X5. (547 aa)
GUCY2DGuanylate cyclase. (1102 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
MUSKMuscle, skeletal receptor tyrosine-protein kinase isoform X14. (869 aa)
ROS1Tyrosine-protein kinase receptor. (2341 aa)
MAP3K21Mitogen-activated protein kinase kinase kinase. (1047 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ROR2Tyrosine-protein kinase transmembrane receptor ROR2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (940 aa)
LCKTyrosine-protein kinase. (539 aa)
SYKTyrosine-protein kinase. (627 aa)
LOC114487554Ephrin type-B receptor 4-like. (163 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
GUCY2CGuanylate cyclase. (1073 aa)
LOC102984527Fibroblast growth factor receptor 4 isoform X1. (366 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
NTRK3Tyrosine-protein kinase receptor. (781 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
DDR1Epithelial discoidin domain-containing receptor 1 isoform X1. (916 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (667 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X4. (606 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
MST1RMacrophage-stimulating protein receptor. (1048 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
EPHA8Ephrin type-A receptor 8. (635 aa)
ZAP70Tyrosine-protein kinase. (617 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.