(109 nodes) Oocyte meiosis network (Physeter catodon)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC112062939	14-3-3 protein homolog; Belongs to the 14-3-3 family. (193 aa)
	ANAPC13	Anaphase-promoting complex subunit 13 isoform X2. (74 aa)
	ENSPCTP00005000285	LOW QUALITY PROTEIN: cullin-1-like. (471 aa)
	CCNB1	G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (433 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	ADCY1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
	SMC1B	Structural maintenance of chromosomes protein. (1236 aa)
	ANAPC10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
	LOC102984889	Speedy protein E4-like. (227 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (758 aa)
	SGO1	Shugoshin 1. (533 aa)
	MAD2L2	Mitotic spindle assembly checkpoint protein MAD2B. (176 aa)
	MAPK12	Mitogen-activated protein kinase. (367 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	CPEB4	Cytoplasmic polyadenylation element-binding protein 4 isoform X2. (339 aa)
	PTTG1	Securin isoform X1. (202 aa)
	PPP2R5A	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
	YWHAH	14-3-3 protein gamma/eta. (176 aa)
	CDC16	Cell division cycle protein 16 homolog isoform X5. (620 aa)
	CALML5	Calmodulin-like. (153 aa)
	FBXO43	F-box only protein 43 isoform X1. (681 aa)
	FBXO5	F-box only protein 5 isoform X1. (447 aa)
	PPP2R1A	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2. (589 aa)
	CDK2	Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
	ADCY5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1260 aa)
	MOS	Proto-oncogene serine/threonine-protein kinase mos; Belongs to the protein kinase superfamily. (346 aa)
	CCNE2	G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa)
	YWHAE	14-3-3 protein epsilon isoform X1; Belongs to the 14-3-3 family. (255 aa)
	MAD2L1	Mitotic spindle assembly checkpoint protein MAD2A. (205 aa)
	AR	Androgen receptor isoform X1. (892 aa)
	ANAPC2	Anaphase-promoting complex subunit 2; Belongs to the cullin family. (820 aa)
	PLK1	Serine/threonine-protein kinase PLK. (604 aa)
	SPDYC	Speedy protein C. (288 aa)
	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	SPDYA	Speedy protein A isoform X2. (312 aa)
	ANAPC1	Anaphase-promoting complex subunit 1 isoform X1. (1944 aa)
	PPP3R1	Calcineurin subunit B type 1. (188 aa)
	CCNB2	G2/mitotic-specific cyclin-B2 isoform X1; Belongs to the cyclin family. (398 aa)
	LOC102982702	S-phase kinase-associated protein 1-like; Belongs to the SKP1 family. (163 aa)
	BUB1	Mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1. (1123 aa)
	ADCY6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	PGR	Progesterone receptor isoform X1. (926 aa)
	YWHAG	14-3-3 protein gamma isoform X1; Belongs to the 14-3-3 family. (247 aa)
	LOC102996886	Calmodulin-like; Belongs to the calmodulin family. (83 aa)
	SKP1	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (309 aa)
	ADCY7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
	CDC26	Anaphase-promoting complex subunit CDC26 isoform X2. (85 aa)
	ANAPC4	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
	STAG3	Cohesin subunit SA-3. (1222 aa)
	ESPL1	Separin. (1572 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	RBX1	E3 ubiquitin-protein ligase RBX1 isoform X1. (108 aa)
	CALM3	Calmodulin-1; Belongs to the calmodulin family. (149 aa)
	ENSPCTP00005017127	LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like. (119 aa)
	YWHAQ	14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
	PLCZ1	Phosphoinositide phospholipase C. (640 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (740 aa)
	SMC1A	Structural maintenance of chromosomes protein. (1233 aa)
	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (678 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
	SMC3	Structural maintenance of chromosomes protein. (1217 aa)
	LOC112062965	cAMP-dependent protein kinase catalytic subunit beta-like. (470 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (522 aa)
	YWHAB	LOW QUALITY PROTEIN: 14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (245 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily. (397 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
	CDC23	Cell division cycle protein 23 homolog. (597 aa)
	CDC25C	M-phase inducer phosphatase 3 isoform X1. (500 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
	IGF1	Insulin-like growth factor 1 transcript variant X1. (186 aa)
	PPP2R5B	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
	CDC27	Cell division cycle protein 27 homolog isoform X6. (831 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (744 aa)
	ENSPCTP00005024342	LOW QUALITY PROTEIN: S-phase kinase-associated protein 1-like. (56 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	CCNE1	G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (745 aa)
	CUL1	Cullin-1 isoform X1; Belongs to the cullin family. (759 aa)
	CPEB2	Cytoplasmic polyadenylation element-binding protein 2 isoform X1. (997 aa)
	CDC20	Cell division cycle protein 20 homolog. (499 aa)
	BTRC	F-box/WD repeat-containing protein 1A isoform X3. (605 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (525 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	CALM2	Calmodulin-2. (82 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
	CALML4	Calmodulin-like protein 4 isoform X1. (120 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (309 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (402 aa)
	CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
	ANAPC7	LOW QUALITY PROTEIN: anaphase-promoting complex subunit 7. (565 aa)
	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Belongs to the protein kinase superfamily. (497 aa)
	SLK	STE20-like serine/threonine-protein kinase isoform X1. (1240 aa)
	ANAPC5	Anaphase-promoting complex subunit 5 isoform X1. (755 aa)
	CDK1	Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. (297 aa)
	ADCY8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1247 aa)
	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1. (717 aa)
	CPEB3	Cytoplasmic polyadenylation element-binding protein 3 isoform X2. (698 aa)
	ANAPC11	Anaphase-promoting complex subunit 11. (84 aa)
	ADCY4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	ADCY9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (577 aa)
	CPEB1	Cytoplasmic polyadenylation element-binding protein 1. (561 aa)
	PPP2R1B	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (668 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)

Your Current Organism:

Physeter catodon

NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY4	ENSPCTP00005000778	ENSPCTP00005030792	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.560
ADCY1	ADCY5	ENSPCTP00005000778	ENSPCTP00005009415	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.542
ADCY1	ADCY6	ENSPCTP00005000778	ENSPCTP00005013762	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.543
ADCY1	ADCY7	ENSPCTP00005000778	ENSPCTP00005014880	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.663
ADCY1	ADCY8	ENSPCTP00005000778	ENSPCTP00005029736	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.954
ADCY1	ADCY9	ENSPCTP00005000778	ENSPCTP00005030902	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.550
ADCY1	ANAPC5	ENSPCTP00005000778	ENSPCTP00005029460	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Anaphase-promoting complex subunit 5 isoform X1.	0.508
ADCY1	ANAPC7	ENSPCTP00005000778	ENSPCTP00005028676	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	LOW QUALITY PROTEIN: anaphase-promoting complex subunit 7.	0.508
ADCY1	CALM2	ENSPCTP00005000778	ENSPCTP00005027290	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-2.	0.951
ADCY1	CALM3	ENSPCTP00005000778	ENSPCTP00005017085	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-1; Belongs to the calmodulin family.	0.951
ADCY1	CALML4	ENSPCTP00005000778	ENSPCTP00005027909	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like protein 4 isoform X1.	0.946
ADCY1	CALML5	ENSPCTP00005000778	ENSPCTP00005007229	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like.	0.951
ADCY1	CAMK2A	ENSPCTP00005000778	ENSPCTP00005028320	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily.	0.914
ADCY1	LOC102996886	ENSPCTP00005000778	ENSPCTP00005014161	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like; Belongs to the calmodulin family.	0.951
ADCY1	LOC112062965	ENSPCTP00005000778	ENSPCTP00005020291	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta-like.	0.923
ADCY1	PRKACA	ENSPCTP00005000778	ENSPCTP00005022748	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.923
ADCY1	PRKACB	ENSPCTP00005000778	ENSPCTP00005020506	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily.	0.929
ADCY4	ADCY1	ENSPCTP00005030792	ENSPCTP00005000778	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.560
ADCY4	ADCY5	ENSPCTP00005030792	ENSPCTP00005009415	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.766
ADCY4	ADCY6	ENSPCTP00005030792	ENSPCTP00005013762	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.975