(31 nodes) Autophagy - other network (Physeter catodon)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC112066681	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (888 aa)
	PIK3R4	Phosphoinositide 3-kinase regulatory subunit 4 isoform X1. (1359 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	BECN2	Beclin-2. (353 aa)
	ATG3	Autophagy-related protein 3. (314 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
	ATG10	Ubiquitin-like-conjugating enzyme ATG10 isoform X1. (234 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (779 aa)
	ULK2	Serine/threonine-protein kinase ULK2 isoform X5. (1027 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
	IGBP1	LOW QUALITY PROTEIN: immunoglobulin-binding protein 1. (337 aa)
	WIPI1	WD repeat domain phosphoinositide-interacting protein 1 isoform X1. (364 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (309 aa)
	BECN1	Beclin-1 isoform X1. (473 aa)
	ATG4A	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (397 aa)
	GABARAPL2	Gamma-aminobutyric acid receptor-associated protein-like 2 isoform X2. (117 aa)
	GABARAP	Gamma-aminobutyric acid receptor-associated protein. (117 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ATG4B	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (393 aa)
	ATG4D	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (473 aa)
	ATG101	Autophagy-related protein 101. (218 aa)
	ATG2A	Autophagy-related protein 2 homolog A isoform X2. (1925 aa)
	WIPI2	WD repeat domain phosphoinositide-interacting protein 2 isoform X2. (454 aa)
	ATG9A	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
	ATG16L1	Autophagy-related protein 16-1. (379 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (309 aa)
	ATG2B	Autophagy-related protein 2 homolog B isoform X4. (2078 aa)
	RPTOR	Regulatory-associated protein of mTOR isoform X2. (1281 aa)
	MLST8	Target of rapamycin complex subunit LST8 isoform X1. (326 aa)
	GABARAPL1	Gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1. (141 aa)
	ATG4C	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)

Your Current Organism:

Physeter catodon

NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG10	ATG101	ENSPCTP00005006857	ENSPCTP00005022991	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Autophagy-related protein 101.	0.581
ATG10	ATG12	ENSPCTP00005006857	ENSPCTP00005001501	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.998
ATG10	ATG16L1	ENSPCTP00005006857	ENSPCTP00005027850	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Autophagy-related protein 16-1.	0.731
ATG10	ATG2A	ENSPCTP00005006857	ENSPCTP00005023213	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Autophagy-related protein 2 homolog A isoform X2.	0.508
ATG10	ATG2B	ENSPCTP00005006857	ENSPCTP00005029189	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Autophagy-related protein 2 homolog B isoform X4.	0.508
ATG10	ATG3	ENSPCTP00005006857	ENSPCTP00005002636	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Autophagy-related protein 3.	0.767
ATG10	ATG4A	ENSPCTP00005006857	ENSPCTP00005018433	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.682
ATG10	ATG4B	ENSPCTP00005006857	ENSPCTP00005020679	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.704
ATG10	ATG4C	ENSPCTP00005006857	ENSPCTP00005032007	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.521
ATG10	ATG4D	ENSPCTP00005006857	ENSPCTP00005021685	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.519
ATG10	ATG5	ENSPCTP00005006857	ENSPCTP00005020569	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.878
ATG10	ATG7	ENSPCTP00005006857	ENSPCTP00005009535	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.974
ATG10	ATG9A	ENSPCTP00005006857	ENSPCTP00005026104	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.561
ATG10	BECN1	ENSPCTP00005006857	ENSPCTP00005015857	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Beclin-1 isoform X1.	0.616
ATG10	GABARAP	ENSPCTP00005006857	ENSPCTP00005019757	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Gamma-aminobutyric acid receptor-associated protein.	0.443
ATG10	GABARAPL1	ENSPCTP00005006857	ENSPCTP00005030401	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1.	0.443
ATG10	GABARAPL2	ENSPCTP00005006857	ENSPCTP00005019449	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Gamma-aminobutyric acid receptor-associated protein-like 2 isoform X2.	0.553
ATG10	LOC112066681	ENSPCTP00005006857	ENSPCTP00005000711	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	0.587
ATG10	PIK3C3	ENSPCTP00005006857	ENSPCTP00005010658	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.441
ATG10	PIK3R4	ENSPCTP00005006857	ENSPCTP00005001306	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Phosphoinositide 3-kinase regulatory subunit 4 isoform X1.	0.441