STRINGSTRING
LOC112062897 LOC112062897 PIK3CB PIK3CB ADCY1 ADCY1 PIK3CA PIK3CA SOD1 SOD1 MTOR MTOR SOD2 SOD2 SIRT1 SIRT1 ADCY5 ADCY5 AKT1 AKT1 AKT1S1 AKT1S1 AKT2 AKT2 INS INS PRKAG1 PRKAG1 FOXA2 FOXA2 ADCY6 ADCY6 PRKAG2 PRKAG2 CAT CAT ADCY7 ADCY7 LOC102995190 LOC102995190 HSPA1L HSPA1L IGF1R IGF1R IRS1 IRS1 HSPA2 HSPA2 FOXO3 FOXO3 FOXO1 FOXO1 LOC112062965 LOC112062965 PRKACB PRKACB ATG5 ATG5 HDAC2 HDAC2 PRKAB2 PRKAB2 EIF4EBP2 EIF4EBP2 PIK3R1 PIK3R1 HDAC1 HDAC1 PRKACA PRKACA IGF1 IGF1 HRAS HRAS PIK3R3 PIK3R3 PRKAA1 PRKAA1 PRKAB1 PRKAB1 IRS2 IRS2 LOC102983803 LOC102983803 CLPB CLPB HSPA8 HSPA8 RPS6KB1 RPS6KB1 RPTOR RPTOR ADCY8 ADCY8 PIK3R2 PIK3R2 ADCY4 ADCY4 ADCY9 ADCY9 CRYAB CRYAB LOC102982336 LOC102982336 PRKAG3 PRKAG3 RPS6KB2 RPS6KB2 PRKAA2 PRKAA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC112062897Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (476 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (245 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (731 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1260 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT1S1Proline-rich AKT1 substrate 1 isoform X1. (276 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (425 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (330 aa)
FOXA2Hepatocyte nuclear factor 3-beta. (463 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X3. (413 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
LOC102995190Heat shock 70 kDa protein 1B; Belongs to the heat shock protein 70 family. (641 aa)
HSPA1LHeat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
IRS1Insulin receptor substrate 1. (1245 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (638 aa)
FOXO3Forkhead box protein O3 isoform X2. (672 aa)
FOXO1Forkhead box protein O1. (433 aa)
LOC112062965cAMP-dependent protein kinase catalytic subunit beta-like. (470 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily. (397 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E-binding protein 2. (120 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (422 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
IGF1Insulin-like growth factor 1 transcript variant X1. (186 aa)
HRASGTPase HRas isoform X2. (189 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1 isoform X1. (270 aa)
IRS2Insulin receptor substrate 2 isoform X1. (1370 aa)
LOC102983803LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like; Belongs to the heat shock protein 70 family. (622 aa)
CLPBCaseinolytic peptidase B protein homolog isoform X1. (707 aa)
HSPA8LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein. (301 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RPTORRegulatory-associated protein of mTOR isoform X2. (1281 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1247 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (577 aa)
CRYABAlpha-crystallin B chain isoform X1; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (173 aa)
LOC102982336LOW QUALITY PROTEIN: insulin receptor substrate 1-like. (540 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3 isoform X4. (486 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (489 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.