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LOC112062816 LOC112062816 AGTR1 AGTR1 ATP1B3 ATP1B3 PPP2R3A PPP2R3A GNAI1 GNAI1 ADCY1 ADCY1 GNAQ GNAQ PPP2R2C PPP2R2C ADRA1A ADRA1A ATP1A2 ATP1A2 MAPK12 MAPK12 MAPK11 MAPK11 PPP2R2B PPP2R2B CREB3L2 CREB3L2 ADRA1B ADRA1B SCN7A SCN7A PIK3CG PIK3CG ATP1B1 ATP1B1 CACNA1C CACNA1C CACNA2D4 CACNA2D4 PPP2R5A PPP2R5A GNAI3 GNAI3 CACNA2D1 CACNA2D1 CREB1 CREB1 CALML5 CALML5 RAPGEF4 RAPGEF4 CACNA1F CACNA1F PPP2R1A PPP2R1A TNNT2 TNNT2 CACNG7 CACNG7 TNNC1 TNNC1 PLCB4 PLCB4 ADCY5 ADCY5 CACNG2 CACNG2 CACNB4 CACNB4 ATF6B ATF6B AKT1 AKT1 ATF2 ATF2 CACNB2 CACNB2 SLC8A1 SLC8A1 AKT2 AKT2 CACNG3 CACNG3 CACNA2D2 CACNA2D2 PPP2R5E PPP2R5E PPP1CB PPP1CB GNAI2 GNAI2 ADRA1D ADRA1D PPP2R3C PPP2R3C BCL2 BCL2 CACNB3 CACNB3 ADCY6 ADCY6 PLCB1 PLCB1 CACNG5 CACNG5 LOC102996886 LOC102996886 CACNG4 CACNG4 CACNG1 CACNG1 AGT AGT PIK3R5 PIK3R5 PPP2CA PPP2CA PIK3R6 PIK3R6 ADCY7 ADCY7 TPM1 TPM1 SLC8A2 SLC8A2 PLN PLN CALM3 CALM3 RPS6KA5 RPS6KA5 MYH6 MYH6 PPP2R5D PPP2R5D MAPK1 MAPK1 ATF4 ATF4 ATP2A3 ATP2A3 CACNA1S CACNA1S PPP2R2D PPP2R2D LOC112062965 LOC112062965 SCN5A SCN5A ATP1B2 ATP1B2 SCN1B SCN1B PRKACB PRKACB MAPK3 MAPK3 SCN4B SCN4B PLCB3 PLCB3 TPM3-2 TPM3-2 CREB3L4 CREB3L4 FXYD2 FXYD2 PRKACA PRKACA CREB3L3 CREB3L3 KCNQ1 KCNQ1 PPP2R5B PPP2R5B MYL4 MYL4 SLC9A1 SLC9A1 CACNG8 CACNG8 LOC102983837 LOC102983837 RYR2 RYR2 ATP1A1 ATP1A1 GNAS GNAS ADRB1 ADRB1 MAPK14 MAPK14 MYL3 MYL3 MAPK13 MAPK13 ATP2B4 ATP2B4 MYL2 MYL2 CALM2 CALM2 TPM2 TPM2 PPP1R1A PPP1R1A PPP1CC PPP1CC CALML4 CALML4 CREB3L1 CREB3L1 PPP2CB PPP2CB AGTR2 AGTR2 ATP2A1 ATP2A1 CAMK2A CAMK2A ATP2B3 ATP2B3 LOC102987258 LOC102987258 ATP2A2 ATP2A2 ADCY8 ADCY8 ACTC1 ACTC1 ATP2B1 ATP2B1 ATP1B4 ATP1B4 ADRB2 ADRB2 ADCY4 ADCY4 ADCY9 ADCY9 LOC114483958 LOC114483958 PPP2R1B PPP2R1B CACNA2D3 CACNA2D3 CACNA1D CACNA1D LOC102987186 LOC102987186 PPP1CA PPP1CA TNNI3 TNNI3
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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LOC112062816Plasma membrane calcium-transporting ATPase 2-like; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (847 aa)
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1151 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
ADRA1Aalpha-1A adrenergic receptor isoform X1. (466 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1. (520 aa)
ADRA1Balpha-1B adrenergic receptor. (518 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1677 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1102 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2187 aa)
CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4. (1066 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X2. (1103 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
CALML5Calmodulin-like. (153 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X1. (1011 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1975 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2. (589 aa)
TNNT2Troponin T, cardiac muscle isoform X2. (226 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (161 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1260 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4 isoform X2. (519 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (976 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (650 aa)
SLC8A1Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (425 aa)
CACNG3Voltage-dependent calcium channel gamma-3 subunit. (315 aa)
CACNA2D2Voltage-dependent calcium channel subunit alpha-2/delta-2. (806 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
ADRA1Dalpha-1D adrenergic receptor. (569 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (230 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3 isoform X1. (484 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit. (275 aa)
LOC102996886Calmodulin-like; Belongs to the calmodulin family. (83 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (225 aa)
AGTAngiotensinogen; Belongs to the serpin family. (517 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (875 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (756 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
TPM1Tropomyosin alpha-1 chain isoform X10; Belongs to the tropomyosin family. (421 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (677 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
CALM3Calmodulin-1; Belongs to the calmodulin family. (149 aa)
RPS6KA5Ribosomal protein S6 kinase. (800 aa)
MYH6Myosin-6 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (678 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (352 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (766 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
LOC112062965cAMP-dependent protein kinase catalytic subunit beta-like. (470 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2018 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
SCN1BSodium channel subunit beta-1 isoform X1. (218 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily. (397 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SCN4BSodium channel subunit beta-4. (228 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
TPM3-2Tropomyosin alpha-3 chain isoform X7; Belongs to the tropomyosin family. (285 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3. (395 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (66 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1 isoform X1; Belongs to the potassium channel family. (676 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
MYL4Myosin light chain 4 isoform X2. (193 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (417 aa)
LOC102983837Potassium voltage-gated channel subfamily E member 1. (132 aa)
RYR2Ryanodine receptor 2. (4967 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoform X1. (395 aa)
ADRB1Beta-1 adrenergic receptor. (470 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MYL3Myosin light chain 3. (199 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
CALM2Calmodulin-2. (82 aa)
TPM2Tropomyosin beta chain isoform X3; Belongs to the tropomyosin family. (284 aa)
PPP1R1AProtein phosphatase 1 regulatory subunit 1A isoform X2. (171 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CALML4Calmodulin-like protein 4 isoform X1. (120 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
AGTR2Type-2 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (362 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1000 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
LOC102987258Neuroendocrine secretory protein 55-like. (241 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (997 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1247 aa)
ACTC1Actin, alpha cardiac muscle 1. (377 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (356 aa)
ADRB2Beta-2 adrenergic receptor isoform X1. (418 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (577 aa)
LOC114483958Sodium/calcium exchanger 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (595 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (668 aa)
CACNA2D3Voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X2. (1091 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
LOC102987186Rap guanine nucleotide exchange factor 3. (85 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
TNNI3Troponin I, cardiac muscle isoform X2. (211 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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