STRINGSTRING
RYK RYK ENSPCTP00005000285 ENSPCTP00005000285 VANGL1 VANGL1 GSK3B GSK3B CSNK1A1 CSNK1A1 PPP3CA PPP3CA APC APC MAPK9 MAPK9 DKK2 DKK2 WNT7B WNT7B LEF1 LEF1 MAPK10 MAPK10 WNT9A WNT9A WNT3A WNT3A VANGL2 VANGL2 FZD1 FZD1 FZD3 FZD3 DVL1 DVL1 WNT2B WNT2B TBL1XR1 TBL1XR1 WIF1 WIF1 CTNND2 CTNND2 BAMBI BAMBI SFRP2 SFRP2 WNT16 WNT16 FZD7 FZD7 WNT2 WNT2 SFRP4 SFRP4 TCF7L1 TCF7L1 LGR6 LGR6 CSNK2A1 CSNK2A1 RSPO4 RSPO4 NFATC2 NFATC2 CCND3 CCND3 CTBP2 CTBP2 FZD5 FZD5 NFATC4 NFATC4 RAC1-2 RAC1-2 DAAM1 DAAM1 PLCB4 PLCB4 PRKCG PRKCG CHD8 CHD8 ZNRF3 ZNRF3 RAC2 RAC2 FZD4 FZD4 SOX17 SOX17 FZD9 FZD9 CTBP1 CTBP1 LGR5 LGR5 PORCN PORCN PRKCB PRKCB MMP7 MMP7 CBY1 CBY1 RSPO3 RSPO3 SENP2 SENP2 PPP3R1 PPP3R1 MAPK8 MAPK8 MAP3K7 MAP3K7 LRP6 LRP6 LOC102988344 LOC102988344 LOC102982702 LOC102982702 DKK4 DKK4 RNF43 RNF43 SIAH1 SIAH1 INVS INVS PLCB1 PLCB1 TCF7 TCF7 RHOA RHOA SKP1 SKP1 NLK NLK NKD1 NKD1 ROR2 ROR2 FRAT1 FRAT1 FRAT2 FRAT2 SFRP1 SFRP1 LGR4 LGR4 FZD8 FZD8 WNT11 WNT11 RBX1 RBX1 CCND2 CCND2 EP300 EP300 CER1 CER1 SERPINF1 SERPINF1 CCND1 CCND1 SOST SOST CSNK2B CSNK2B PRICKLE2 PRICKLE2 CACYBP CACYBP FZD2 FZD2 SMAD4 SMAD4 ROCK2 ROCK2 LOC112062942 LOC112062942 SFRP5 SFRP5 LRP5 LRP5 DVL2 DVL2 NFATC1 NFATC1 TP53 TP53 LOC112062965 LOC112062965 PPP3CC PPP3CC PRKACB PRKACB PLCB3 PLCB3 WNT8A WNT8A NFATC3 NFATC3 WNT1 WNT1 AXIN1 AXIN1 WNT10B WNT10B PRKACA PRKACA MYC MYC WNT9B WNT9B WNT3 WNT3 WNT4 WNT4 TCF7L2 TCF7L2 PRICKLE1 PRICKLE1 FZD10 FZD10 PSEN1 PSEN1 ENSPCTP00005024342 ENSPCTP00005024342 WNT8B WNT8B CUL1 CUL1 SMAD3 SMAD3 DKK1 DKK1 BTRC BTRC PRICKLE4 PRICKLE4 RSPO2 RSPO2 PPP3CB PPP3CB PRICKLE3 PRICKLE3 LOC102990422 LOC102990422 CTNNB1 CTNNB1 FOSL1 FOSL1 WNT6 WNT6 WNT10A WNT10A GPC4 GPC4 JUN JUN RSPO1 RSPO1 NOTUM NOTUM CSNK2A2 CSNK2A2 CAMK2A CAMK2A APC2 APC2 DAAM2 DAAM2 LOC102981665 LOC102981665 RUVBL1 RUVBL1 FZD6 FZD6 CXXC4 CXXC4 RAC3 RAC3 DVL3 DVL3 WNT7A WNT7A CREBBP CREBBP WNT5A WNT5A PPARD PPARD ROR1 ROR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RYKTyrosine-protein kinase RYK isoform X1. (609 aa)
ENSPCTP00005000285LOW QUALITY PROTEIN: cullin-1-like. (471 aa)
VANGL1Vang-like protein. (524 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
CSNK1A1Casein kinase I isoform X4. (264 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
APCAdenomatous polyposis coli protein isoform X1. (2875 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
DKK2Dickkopf-related protein 2 isoform X2. (258 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
VANGL2Vang-like protein. (521 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
FZD3Frizzled-3 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
TBL1XR1F-box-like/WD repeat-containing protein TBL1XR1 isoform X2. (514 aa)
WIF1Wnt inhibitory factor 1. (379 aa)
CTNND2Catenin delta-2 isoform X1. (1228 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
SFRP4Secreted frizzled-related protein 4 isoform X1. (346 aa)
TCF7L1Transcription factor 7-like 1. (586 aa)
LGR6Leucine-rich repeat-containing G-protein coupled receptor 6. (887 aa)
CSNK2A1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
RSPO4R-spondin-4. (230 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X4. (915 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (358 aa)
CTBP2C-terminal-binding protein 2 isoform X1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (976 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4. (933 aa)
RAC1-2Ras-related C3 botulinum toxin substrate 1. (185 aa)
DAAM1Disheveled-associated activator of morphogenesis 1 isoform X2. (1078 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2582 aa)
ZNRF3E3 ubiquitin-protein ligase ZNRF3. (938 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
FZD4Frizzled-4 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
SOX17Transcription factor SOX-17. (407 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
CTBP1C-terminal-binding protein 1 isoform X1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (422 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1. (907 aa)
PORCNProtein-serine O-palmitoleoyltransferase porcupine isoform X1; Belongs to the membrane-bound acyltransferase family. (461 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MMP7LOW QUALITY PROTEIN: matrilysin. (269 aa)
CBY1Protein chibby homolog 1. (127 aa)
RSPO3R-spondin-3. (275 aa)
SENP2Sentrin-specific protease 2. (560 aa)
PPP3R1Calcineurin subunit B type 1. (188 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
LOC102988344Nuclear factor of activated T-cells, cytoplasmic 1. (453 aa)
LOC102982702S-phase kinase-associated protein 1-like; Belongs to the SKP1 family. (163 aa)
DKK4Dickkopf-related protein 4. (167 aa)
RNF43E3 ubiquitin-protein ligase RNF43 isoform X1. (783 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
INVSInversin isoform X1. (1079 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
TCF7Transcription factor 7 isoform X3. (480 aa)
RHOARas homolog gene family, member A. (287 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
NKD1Protein naked cuticle homolog 1 isoform X1. (471 aa)
ROR2Tyrosine-protein kinase transmembrane receptor ROR2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (940 aa)
FRAT1Proto-oncogene FRAT1. (280 aa)
FRAT2GSK-3-binding protein FRAT2. (232 aa)
SFRP1Secreted frizzled-related protein 1. (307 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
FZD8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (678 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X1. (108 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
EP300Histone acetyltransferase p300 isoform X2. (2353 aa)
CER1Cerberus. (267 aa)
SERPINF1Pigment epithelium-derived factor; Belongs to the serpin family. (437 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
SOSTSclerostin. (212 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (249 aa)
PRICKLE2Prickle-like protein 2 isoform X1. (900 aa)
CACYBPCalcyclin-binding protein isoform X1. (230 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
ROCK2Rho-associated protein kinase 2 isoform X5; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1387 aa)
LOC112062942RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (505 aa)
SFRP5Secreted frizzled-related protein 5. (315 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1435 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X5. (732 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (460 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
LOC112062965cAMP-dependent protein kinase catalytic subunit beta-like. (470 aa)
PPP3CCSerine/threonine-protein phosphatase. (522 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily. (397 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (298 aa)
AXIN1Axin-1 isoform X1. (609 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
TCF7L2Transcription factor 7-like 2 isoform X4. (669 aa)
PRICKLE1Prickle-like protein 1. (834 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (464 aa)
ENSPCTP00005024342LOW QUALITY PROTEIN: S-phase kinase-associated protein 1-like. (56 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
CUL1Cullin-1 isoform X1; Belongs to the cullin family. (759 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
DKK1Dickkopf-related protein 1. (268 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X3. (605 aa)
PRICKLE4Prickle-like protein 4 isoform X3. (401 aa)
RSPO2R-spondin-2 isoform X2. (242 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
PRICKLE3Prickle planar cell polarity protein 3 isoform X1. (615 aa)
LOC102990422Axin-2 isoform X1. (174 aa)
CTNNB1Catenin beta-1. (783 aa)
FOSL1Fos-related antigen 1 isoform X1. (271 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
GPC4Glypican-4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
RSPO1R-spondin-1 isoform X1. (262 aa)
NOTUMPalmitoleoyl-protein carboxylesterase NOTUM. (499 aa)
CSNK2A2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (350 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
APC2Adenomatous polyposis coli protein 2. (2257 aa)
DAAM2Disheveled-associated activator of morphogenesis 2 isoform X1. (1088 aa)
LOC102981665Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (416 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
CXXC4CXXC-type zinc finger protein 4. (383 aa)
RAC3Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X2. (716 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (337 aa)
CREBBPCREB-binding protein. (1362 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
ROR1Inactive tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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