STRINGSTRING
TRPC1 TRPC1 PIK3CB PIK3CB NCK1 NCK1 EPHB1 EPHB1 RYK RYK MET MET LOC114486275 LOC114486275 GSK3B GSK3B GNAI1 GNAI1 CXCR4 CXCR4 PPP3CA PPP3CA EPHA1 EPHA1 FES FES EPHA5 EPHA5 SEMA6A SEMA6A SMO SMO SEMA4B SEMA4B SLIT3 SLIT3 DPYSL2 DPYSL2 BOC BOC PRKCZ PRKCZ SRGAP1 SRGAP1 FZD3 FZD3 ITGB1 ITGB1 NRP1 NRP1 PIK3CA PIK3CA PARD3 PARD3 PLXNB2 PLXNB2 BMPR1B BMPR1B PAK2 PAK2 BMPR2 BMPR2 GNAI3 GNAI3 SEMA3D SEMA3D SEMA3A SEMA3A SEMA3E SEMA3E ILK ILK PDK1 PDK1 SEMA3C SEMA3C PTCH1 PTCH1 NFATC2 NFATC2 PARD6B PARD6B LOC114487449 LOC114487449 NFATC4 NFATC4 RAC1-2 RAC1-2 NTN4 NTN4 MYL9 MYL9 RASA1 RASA1 RAF1 RAF1 PAK5 PAK5 RAC2 RAC2 SEMA5B SEMA5B SHH SHH EFNB1 EFNB1 SSH2 SSH2 SEMA3B SEMA3B SEMA4C SEMA4C GNAI2 GNAI2 CFL2 CFL2 SEMA3F SEMA3F EPHA8 EPHA8 PPP3R1 PPP3R1 CDC42 CDC42 PAK1 PAK1 MYL5 MYL5 ABL1 ABL1 RND1 RND1 TRPC3 TRPC3 TRPC6 TRPC6 RGS3 RGS3 NTN1 NTN1 RHOD RHOD SEMA4A SEMA4A SEMA4D SEMA4D RHOA RHOA RRAS RRAS SSH3 SSH3 EFNA4 EFNA4 CXCL12 CXCL12 TRPC4 TRPC4 RGMA RGMA CDK5 CDK5 PTPN11 PTPN11 NEO1 NEO1 LRRC4 LRRC4 EFNA3 EFNA3 PLCG1 PLCG1 LRRC4C LRRC4C MAPK1 MAPK1 ROCK2 ROCK2 PLXNA3 PLXNA3 NCK2 NCK2 PPP3CC PPP3CC MAPK3 MAPK3 SLIT1 SLIT1 SRGAP2 SRGAP2 SEMA4F SEMA4F PIK3R1 PIK3R1 DCC DCC SLIT2 SLIT2 SEMA7A SEMA7A NFATC3 NFATC3 FYN FYN PARD6G PARD6G PARD6A PARD6A SLC29A3 SLC29A3 ROBO3 ROBO3 MYL12A MYL12A EPHB6 EPHB6 LIMK1 LIMK1 PAK4 PAK4 EPHA6 EPHA6 WNT4 WNT4 SEMA6D SEMA6D GDF7 GDF7 EPHA3 EPHA3 PTK2 PTK2 PLCG2 PLCG2 LIMK2 LIMK2 HRAS HRAS PIK3R3 PIK3R3 EFNA2 EFNA2 SSH1 SSH1 SEMA3G SEMA3G EFNB2 EFNB2 TRPC5 TRPC5 PPP3CB PPP3CB EPHA7 EPHA7 UNC5D UNC5D EFNA5 EFNA5 PLXNA1 PLXNA1 ROBO1 ROBO1 SEMA6B SEMA6B LOC102976695 LOC102976695 EPHB3 EPHB3 BMP7 BMP7 ROBO2 ROBO2 ROCK1 ROCK1 SEMA6C SEMA6C CAMK2A CAMK2A PAK6 PAK6 PLXNB1 PLXNB1 PLXNB3 PLXNB3 EPHB4 EPHB4 EPHA4 EPHA4 EFNB3 EFNB3 ARHGEF12 ARHGEF12 L1CAM L1CAM EFNA1 EFNA1 PIK3R2 PIK3R2 RAC3 RAC3 PLXNC1 PLXNC1 EPHB2 EPHB2 SEMA4G SEMA4G WNT5A WNT5A PLXNA2 PLXNA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRPC1Short transient receptor potential channel 1 isoform X4; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
NCK1Cytoplasmic protein. (377 aa)
EPHB1Ephrin type-B receptor 1. (984 aa)
RYKTyrosine-protein kinase RYK isoform X1. (609 aa)
METHepatocyte growth factor receptor. (1412 aa)
LOC114486275plexin-A4-like. (456 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
CXCR4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
EPHA1Ephrin type-A receptor 1. (979 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
EPHA5Ephrin type-A receptor 5 isoform X1. (1037 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1045 aa)
SMOSmoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
SEMA4Bsemaphorin-4B isoform X1; Belongs to the semaphorin family. (827 aa)
SLIT3Slit homolog 3 protein. (1530 aa)
DPYSL2Dihydropyrimidinase-related protein 2 isoform X1. (677 aa)
BOCBrother of CDO. (150 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
SRGAP1SLIT-ROBO Rho GTPase-activating protein 1 isoform X1. (1084 aa)
FZD3Frizzled-3 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PARD3Partitioning defective 3 homolog isoform X2. (1356 aa)
PLXNB2plexin-B2 isoform X1. (1841 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (531 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1049 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
SEMA3Dsemaphorin-3D; Belongs to the semaphorin family. (777 aa)
SEMA3Asemaphorin-3A; Belongs to the semaphorin family. (772 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (775 aa)
ILKIntegrin-linked protein kinase. (452 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
SEMA3Csemaphorin-3C isoform X1; Belongs to the semaphorin family. (777 aa)
PTCH1Protein patched homolog 1. (1449 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X4. (915 aa)
PARD6BPartitioning defective 6 homolog beta. (372 aa)
LOC114487449netrin-G2-like. (298 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4. (933 aa)
RAC1-2Ras-related C3 botulinum toxin substrate 1. (185 aa)
NTN4Netrin-4 isoform X2. (628 aa)
MYL9Myosin regulatory light polypeptide 9. (183 aa)
RASA1Ras GTPase-activating protein 1 isoform X2. (1040 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
SEMA5Bsemaphorin-5B isoform X2. (1092 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (452 aa)
EFNB1ephrin-B1; Belongs to the ephrin family. (346 aa)
SSH2Protein phosphatase Slingshot homolog 2 isoform X1. (1449 aa)
SEMA3Bsemaphorin-3B isoform X1; Belongs to the semaphorin family. (753 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
SEMA3Fsemaphorin-3F isoform X1; Belongs to the semaphorin family. (785 aa)
EPHA8Ephrin type-A receptor 8. (635 aa)
PPP3R1Calcineurin subunit B type 1. (188 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
MYL5Myosin light chain 5. (174 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
RND1Rho-related GTP-binding protein Rho6. (232 aa)
TRPC3Short transient receptor potential channel 3 isoform X2; Belongs to the transient receptor (TC 1.A.4) family. (920 aa)
TRPC6Short transient receptor potential channel 6 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
RGS3Regulator of G-protein signaling 3 isoform X1. (914 aa)
NTN1Netrin-1 isoform X1. (243 aa)
RHODRho-related GTP-binding protein RhoD. (220 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (762 aa)
SEMA4Dsemaphorin-4D isoform X1; Belongs to the semaphorin family. (863 aa)
RHOARas homolog gene family, member A. (287 aa)
RRASRas-related protein R-Ras. (218 aa)
SSH3Protein phosphatase Slingshot homolog 3 isoform X1. (652 aa)
EFNA4ephrin-A4 isoform X1; Belongs to the ephrin family. (204 aa)
CXCL12Stromal cell-derived factor 1; Belongs to the intercrine alpha (chemokine CxC) family. (89 aa)
TRPC4Short transient receptor potential channel 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
RGMARepulsive guidance molecule A isoform X2. (47 aa)
CDK5Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
NEO1Neogenin isoform X7. (1462 aa)
LRRC4Leucine-rich repeat-containing protein 4. (568 aa)
EFNA3ephrin-A3; Belongs to the ephrin family. (262 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1165 aa)
LRRC4CLeucine-rich repeat-containing protein 4C. (640 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
ROCK2Rho-associated protein kinase 2 isoform X5; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1387 aa)
PLXNA3plexin-A3. (1872 aa)
NCK2Cytoplasmic protein. (375 aa)
PPP3CCSerine/threonine-protein phosphatase. (522 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SLIT1Slit homolog 1 protein. (1396 aa)
SRGAP2SLIT-ROBO Rho GTPase-activating protein 2. (459 aa)
SEMA4Fsemaphorin-4F isoform X3; Belongs to the semaphorin family. (772 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
DCCNetrin receptor DCC. (1446 aa)
SLIT2Slit homolog 2 protein isoform X1. (1543 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (649 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa)
FYNTyrosine-protein kinase. (537 aa)
PARD6GPartitioning defective 6 homolog gamma. (357 aa)
PARD6APartitioning defective 6 homolog alpha. (346 aa)
SLC29A3Netrin receptor UNC5B isoform X1. (1406 aa)
ROBO3Roundabout homolog 3. (534 aa)
MYL12AMyosin regulatory light polypeptide 9 isoform X1. (178 aa)
EPHB6Ephrin type-B receptor 6. (1009 aa)
LIMK1LIM domain kinase 1. (628 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
EPHA6Ephrin type-A receptor 6 isoform X2. (1129 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SEMA6Dsemaphorin-6D isoform X1; Belongs to the semaphorin family. (1073 aa)
GDF7Growth/differentiation factor 7. (449 aa)
EPHA3Ephrin type-A receptor 3 isoform X1. (984 aa)
PTK2Focal adhesion kinase 1 isoform X10; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
LIMK2LIM domain kinase 2 isoform X1. (599 aa)
HRASGTPase HRas isoform X2. (189 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
EFNA2ephrin-A2; Belongs to the ephrin family. (214 aa)
SSH1Protein phosphatase Slingshot homolog 1. (954 aa)
SEMA3Gsemaphorin-3G; Belongs to the semaphorin family. (772 aa)
EFNB2ephrin-B2; Belongs to the ephrin family. (333 aa)
TRPC5Short transient receptor potential channel 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (998 aa)
UNC5DNetrin receptor UNC5D. (958 aa)
EFNA5ephrin-A5 isoform X1; Belongs to the ephrin family. (248 aa)
PLXNA1plexin-A1. (1891 aa)
ROBO1Roundabout homolog 1. (1649 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (876 aa)
LOC102976695Ephexin-1. (131 aa)
EPHB3Ephrin type-B receptor 3. (997 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
ROBO2LOW QUALITY PROTEIN: roundabout homolog 2. (1439 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
SEMA6Csemaphorin-6C isoform X1; Belongs to the semaphorin family. (966 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
PAK6Non-specific serine/threonine protein kinase. (676 aa)
PLXNB1plexin-B1 isoform X9. (2135 aa)
PLXNB3LOW QUALITY PROTEIN: plexin-B3. (1903 aa)
EPHB4Ephrin type-B receptor 4. (307 aa)
EPHA4Ephrin type-A receptor 4. (986 aa)
EFNB3ephrin-B3; Belongs to the ephrin family. (340 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12 isoform X1. (1544 aa)
L1CAMNeural cell adhesion molecule L1. (1257 aa)
EFNA1ephrin-A1 isoform X2; Belongs to the ephrin family. (142 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
RAC3Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa)
PLXNC1plexin-C1 isoform X1. (1572 aa)
EPHB2Ephrin type-B receptor 2. (691 aa)
SEMA4Gsemaphorin-4G isoform X1; Belongs to the semaphorin family. (843 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PLXNA2plexin-A2 isoform X1. (1556 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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