STRINGSTRING
LOC112062939 LOC112062939 WWTR1 WWTR1 TP53BP2 TP53BP2 GSK3B GSK3B APC APC PPP2R2C PPP2R2C TP73 TP73 LOC112065317 LOC112065317 WNT7B WNT7B WWC1 WWC1 LEF1 LEF1 CRB1 CRB1 LOC102991425 LOC102991425 PRKCI PRKCI WNT9A WNT9A SMAD1 SMAD1 WNT3A WNT3A FGF1 FGF1 PRKCZ PRKCZ FZD1 FZD1 FZD3 FZD3 MOB1B MOB1B DVL1 DVL1 WNT2B WNT2B TGFB2 TGFB2 PARD3 PARD3 PPP2R2B PPP2R2B GLI2 GLI2 WNT16 WNT16 DLG1 DLG1 FZD7 FZD7 BMPR1B BMPR1B BMPR2 BMPR2 AFP AFP WNT2 WNT2 LOC102982024 LOC102982024 RASSF6 RASSF6 SOX2 SOX2 AREG AREG BIRC5 BIRC5 YWHAH YWHAH TCF7L1 TCF7L1 CCND3 CCND3 PARD6B PARD6B FZD5 FZD5 STK3 STK3 DLG5 DLG5 PPP2R1A PPP2R1A NF2 NF2 LLGL2 LLGL2 GDF6 GDF6 BMP6 BMP6 YWHAE YWHAE LATS1 LATS1 FZD4 FZD4 FZD9 FZD9 GDF5 GDF5 BIRC2 BIRC2 PPP1CB PPP1CB YAP1 YAP1 CCN2 CCN2 SMAD2 SMAD2 BMP2 BMP2 YWHAG YWHAG DLG2 DLG2 TCF7 TCF7 PPP2CA PPP2CA LATS2 LATS2 TGFBR2 TGFBR2 NKD1 NKD1 LIMD1 LIMD1 SNAI2 SNAI2 TEAD4 TEAD4 FZD8 FZD8 WNT11 WNT11 CCND2 CCND2 LOC102983581-2 LOC102983581-2 ENSPCTP00005017127 ENSPCTP00005017127 CCND1 CCND1 LLGL1 LLGL1 YWHAQ YWHAQ WTIP WTIP FZD2 FZD2 SMAD4 SMAD4 ID2 ID2 CTNNA2 CTNNA2 MPP5 MPP5 DVL2 DVL2 CRB2 CRB2 SAV1 SAV1 PPP2R2D PPP2R2D YWHAB YWHAB ID1 ID1 WNT8A WNT8A WNT1 WNT1 AXIN1 AXIN1 PARD6G PARD6G DLG4 DLG4 PARD6A PARD6A WNT10B WNT10B TEAD2 TEAD2 TGFB3 TGFB3 MYC MYC WNT9B WNT9B WNT3 WNT3 WNT4 WNT4 TCF7L2 TCF7L2 FZD10 FZD10 CTNNA1 CTNNA1 CDH1 CDH1 TGFB1 TGFB1 GDF7 GDF7 LOC102988905 LOC102988905 RASSF1 RASSF1 WNT8B WNT8B ITGB2 ITGB2 SMAD3 SMAD3 SERPINE1 SERPINE1 BTRC BTRC AMOT AMOT LOC102990422 LOC102990422 CTNNB1 CTNNB1 WNT6 WNT6 WNT10A WNT10A CSNK1D CSNK1D BMP7 BMP7 AMH AMH PPP1CC PPP1CC PPP2CB PPP2CB BMP5 BMP5 FRMD6 FRMD6 APC2 APC2 LOC102981665 LOC102981665 FZD6 FZD6 ACTG1 ACTG1 DVL3 DVL3 CTNNA3 CTNNA3 WNT7A WNT7A PPP2R1B PPP2R1B WNT5A WNT5A TEAD3 TEAD3 PPP1CA PPP1CA BMP4 BMP4 PATJ PATJ
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC11206293914-3-3 protein homolog; Belongs to the 14-3-3 family. (193 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
TP53BP2Apoptosis-stimulating of p53 protein 2. (1136 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
APCAdenomatous polyposis coli protein isoform X1. (2875 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (641 aa)
LOC112065317Bone morphogenetic protein 8B. (238 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
WWC1Protein KIBRA. (1119 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
CRB1Protein crumbs homolog 1. (1406 aa)
LOC102991425Bone morphogenetic protein 8B. (403 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
FZD3Frizzled-3 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
MOB1BMOB kinase activator 1B isoform X1. (221 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PARD3Partitioning defective 3 homolog isoform X2. (1356 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
GLI2Zinc finger protein GLI2 isoform X1. (1563 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (531 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1049 aa)
AFPAlpha-fetoprotein. (610 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
LOC102982024Alpha-fetoprotein-like. (607 aa)
RASSF6Ras association domain-containing protein 6. (365 aa)
SOX2Transcription factor SOX-2. (323 aa)
AREGAmphiregulin isoform X1. (275 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
YWHAH14-3-3 protein gamma/eta. (176 aa)
TCF7L1Transcription factor 7-like 1. (586 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (358 aa)
PARD6BPartitioning defective 6 homolog beta. (372 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
STK3Serine/threonine-protein kinase 3 isoform X2. (491 aa)
DLG5Disks large homolog 5 isoform X2. (1644 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2. (589 aa)
NF2Merlin. (541 aa)
LLGL2Lethal(2) giant larvae protein homolog 2 isoform X6. (1020 aa)
GDF6Growth/differentiation factor 6. (461 aa)
BMP6Bone morphogenetic protein 6. (493 aa)
YWHAE14-3-3 protein epsilon isoform X1; Belongs to the 14-3-3 family. (255 aa)
LATS1Serine/threonine-protein kinase LATS1 isoform X1. (1128 aa)
FZD4Frizzled-4 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
GDF5Growth/differentiation factor 5. (499 aa)
BIRC2Baculoviral IAP repeat-containing protein 2 isoform X1. (621 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
YAP1Transcriptional coactivator YAP1 isoform X2. (509 aa)
CCN2Connective tissue growth factor. (349 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
YWHAG14-3-3 protein gamma isoform X1; Belongs to the 14-3-3 family. (247 aa)
DLG2Disks large homolog 2 isoform X2. (904 aa)
TCF7Transcription factor 7 isoform X3. (480 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
LATS2Serine/threonine-protein kinase LATS2. (1041 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
NKD1Protein naked cuticle homolog 1 isoform X1. (471 aa)
LIMD1LIM domain-containing protein 1 isoform X1. (669 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
TEAD4Transcriptional enhancer factor TEF-3 isoform X2. (434 aa)
FZD8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (678 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
LOC102983581-2LIM domain-containing protein ajuba isoform X1. (557 aa)
ENSPCTP00005017127LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like. (119 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
LLGL1Lethal(2) giant larvae protein homolog 1 isoform X2. (1065 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
WTIPWilms tumor protein 1-interacting protein. (434 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
CTNNA2Catenin alpha-2 isoform X1. (953 aa)
MPP5MAGUK p55 subfamily member 5 isoform X1; Belongs to the MAGUK family. (675 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X5. (732 aa)
CRB2Protein crumbs homolog 2. (1281 aa)
SAV1Protein salvador homolog 1. (384 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
YWHABLOW QUALITY PROTEIN: 14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (245 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (298 aa)
AXIN1Axin-1 isoform X1. (609 aa)
PARD6GPartitioning defective 6 homolog gamma. (357 aa)
DLG4Disks large homolog 4 isoform X2; Belongs to the MAGUK family. (696 aa)
PARD6APartitioning defective 6 homolog alpha. (346 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
TEAD2Transcriptional enhancer factor TEF-4 isoform X3. (451 aa)
TGFB3Transforming growth factor beta-3 proprotein. (456 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
TCF7L2Transcription factor 7-like 2 isoform X4. (669 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
CTNNA1Catenin alpha-1. (906 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GDF7Growth/differentiation factor 7. (449 aa)
LOC102988905Actin, cytoplasmic 1. (375 aa)
RASSF1Ras association domain-containing protein 1 isoform X2. (272 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ITGB2Integrin beta. (769 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X3. (605 aa)
AMOTAngiomotin. (590 aa)
LOC102990422Axin-2 isoform X1. (174 aa)
CTNNB1Catenin beta-1. (783 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
CSNK1DCasein kinase I isoform X2. (396 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
AMHMuellerian-inhibiting factor. (560 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
BMP5Bone morphogenetic protein 5 isoform X1. (454 aa)
FRMD6FERM domain-containing protein 6 isoform X1. (622 aa)
APC2Adenomatous polyposis coli protein 2. (2257 aa)
LOC102981665Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (416 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X2. (716 aa)
CTNNA3Catenin alpha-3 isoform X1. (895 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (337 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (668 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (435 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
PATJinaD-like protein isoform X4. (1878 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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