STRINGSTRING
PIK3CB PIK3CB CAPN2 CAPN2 MET MET CAV1 CAV1 GSK3B GSK3B CAV2 CAV2 VAV3 VAV3 PDGFC PDGFC ZYX ZYX FLT4 FLT4 PARVG PARVG THBS2 THBS2 COL9A2 COL9A2 MAPK9 MAPK9 VEGFD VEGFD COL6A6 COL6A6 EGFR EGFR COL6A5 COL6A5 DIAPH1 DIAPH1 MAPK10 MAPK10 ITGB8 ITGB8 IBSP IBSP SPP1 SPP1 ITGB1 ITGB1 LAMC1 LAMC1 RAP1A RAP1A PIK3CA PIK3CA LAMC2 LAMC2 RELN RELN RAP1B RAP1B COL1A2 COL1A2 EGF EGF PAK2 PAK2 LAMB1 LAMB1 PIP5K1B PIP5K1B THBS4 THBS4 ILK ILK VAV2 VAV2 ITGA6 ITGA6 VEGFC VEGFC ITGA9 ITGA9 PDGFA PDGFA HGF HGF CCND3 CCND3 KDR KDR RAC1-2 RAC1-2 PDGFRA PDGFRA MYL7 MYL7 ITGA2 ITGA2 MYL9 MYL9 RAF1 RAF1 ITGB4 ITGB4 MYLK MYLK PRKCG PRKCG PAK5 PAK5 AKT1 AKT1 RAC2 RAC2 TNXB TNXB SOS1 SOS1 CRK CRK ERBB2 ERBB2 PDGFD PDGFD ARHGAP5 ARHGAP5 ITGA7 ITGA7 LAMA2 LAMA2 AKT2 AKT2 PRKCB PRKCB BIRC2 BIRC2 PPP1CB PPP1CB ITGA8 ITGA8 CDC42 CDC42 MAPK8 MAPK8 LAMC3 LAMC3 PAK1 PAK1 MYL5 MYL5 BCL2 BCL2 SHC3 SHC3 LOC102991626 LOC102991626 MYL10 MYL10 RHOA RHOA TLN2 TLN2 ITGA5 ITGA5 ITGB6 ITGB6 COL9A3 COL9A3 ITGA4 ITGA4 ITGB7 ITGB7 SOS2 SOS2 COMP COMP ARHGAP35 ARHGAP35 IGF1R IGF1R CCND2 CCND2 LAMA1 LAMA1 CCND1 CCND1 COL2A1 COL2A1 COL4A4 COL4A4 SHC1 SHC1 PDGFB PDGFB PPP1R12A PPP1R12A ITGA10 ITGA10 COL4A3 COL4A3 VWF VWF FLNA FLNA BCAR1 BCAR1 VEGFA VEGFA VAV1 VAV1 MAPK1 MAPK1 TNR TNR ROCK2 ROCK2 LAMB2 LAMB2 SHC4 SHC4 VEGFB VEGFB FLT1 FLT1 MAPK3 MAPK3 COL4A6 COL4A6 ITGAV ITGAV LAMA4 LAMA4 PIK3R1 PIK3R1 BAD BAD FYN FYN MYL12A MYL12A COL4A5 COL4A5 PAK4 PAK4 IGF1 IGF1 MYLPF MYLPF FN1 FN1 VTN VTN LOC102988905 LOC102988905 PTK2 PTK2 ITGB3 ITGB3 MAP2K1 MAP2K1 MYLK2 MYLK2 LAMB3 LAMB3 HRAS HRAS PIK3R3 PIK3R3 CRKL CRKL CTNNB1 CTNNB1 PIP5K1C PIP5K1C ITGA2B ITGA2B JUN JUN PIP5K1A PIP5K1A COL4A1 COL4A1 MYL2 MYL2 PDPK1 PDPK1 COL9A1 COL9A1 PDGFRB PDGFRB PXN PXN PTEN PTEN TNC TNC ROCK1 ROCK1 ITGA3 ITGA3 PPP1CC PPP1CC COL6A1 COL6A1 COL6A2 COL6A2 COL1A1 COL1A1 PAK6 PAK6 ITGA11 ITGA11 VCL VCL TLN1 TLN1 FLNB FLNB THBS1 THBS1 THBS3 THBS3 ITGA1 ITGA1 PIK3R2 PIK3R2 ACTG1 ACTG1 RAC3 RAC3 XIAP XIAP COL6A3 COL6A3 ELK1 ELK1 LAMA3 LAMA3 PPP1CA PPP1CA GRB2 GRB2 PPP1R12C PPP1R12C FLNC FLNC PARVB PARVB PGF PGF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CAPN2Calpain-2 catalytic subunit isoform X1; Belongs to the peptidase C2 family. (727 aa)
METHepatocyte growth factor receptor. (1412 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
VAV3LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV3. (875 aa)
PDGFCPlatelet-derived growth factor C isoform X1. (380 aa)
ZYXZyxin. (566 aa)
FLT4Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
PARVGGamma-parvin. (331 aa)
THBS2Thrombospondin-2. (1170 aa)
COL9A2LOW QUALITY PROTEIN: collagen alpha-2(IX) chain. (688 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
COL6A6Collagen alpha-6(VI) chain. (2223 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
COL6A5Collagen alpha-5(VI) chain. (2603 aa)
DIAPH1Protein diaphanous homolog 1 isoform X2. (1216 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
IBSPBone sialoprotein 2. (312 aa)
SPP1Osteopontin. (295 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
LAMC1Laminin subunit gamma-1. (1608 aa)
RAP1ARas-related protein Rap-1A isoform X1. (184 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LAMC2Laminin subunit gamma-2. (1191 aa)
RELNReelin isoform X1. (3460 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
COL1A2Collagen alpha-2(I) chain. (1366 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1206 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
LAMB1Laminin subunit beta-1. (1786 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (540 aa)
THBS4Thrombospondin-4. (961 aa)
ILKIntegrin-linked protein kinase. (452 aa)
VAV2Guanine nucleotide exchange factor VAV2. (864 aa)
ITGA6Integrin alpha-6 isoform X1; Belongs to the integrin alpha chain family. (1130 aa)
VEGFCVascular endothelial growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (421 aa)
ITGA9Integrin alpha-9 isoform X1; Belongs to the integrin alpha chain family. (1035 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (158 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (358 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
RAC1-2Ras-related C3 botulinum toxin substrate 1. (185 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
MYL7Myosin regulatory light chain 2, atrial isoform. (175 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1072 aa)
MYL9Myosin regulatory light polypeptide 9. (183 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
ITGB4Integrin beta. (1808 aa)
MYLKMyosin light chain kinase, smooth muscle isoform X1. (1917 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
TNXBLOW QUALITY PROTEIN: tenascin-X. (705 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
ERBB2Receptor protein-tyrosine kinase. (1302 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (370 aa)
ARHGAP5Rho GTPase-activating protein 5 isoform X2. (1503 aa)
ITGA7Integrin alpha-7 isoform X2; Belongs to the integrin alpha chain family. (1185 aa)
LAMA2Laminin subunit alpha-2 isoform X5. (3124 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (425 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
BIRC2Baculoviral IAP repeat-containing protein 2 isoform X1. (621 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ITGA8Integrin alpha-8 isoform X1; Belongs to the integrin alpha chain family. (1062 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
LAMC3Laminin subunit gamma-3. (445 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
MYL5Myosin light chain 5. (174 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (230 aa)
SHC3SHC-transforming protein 3. (584 aa)
LOC102991626Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
MYL10Myosin regulatory light chain 10. (168 aa)
RHOARas homolog gene family, member A. (287 aa)
TLN2Talin-2. (2486 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1054 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
COL9A3Collagen alpha-3(IX) chain. (684 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1033 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (800 aa)
SOS2Son of sevenless homolog 2. (1331 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
LAMA1Laminin subunit alpha-1. (3079 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
COL2A1Collagen alpha-1(II) chain isoform X1. (1487 aa)
COL4A4Collagen alpha-4(IV) chain. (1690 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X2; Belongs to the PDGF/VEGF growth factor family. (240 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
ITGA10LOW QUALITY PROTEIN: integrin alpha-10; Belongs to the integrin alpha chain family. (1171 aa)
COL4A3Collagen alpha-3(IV) chain. (1670 aa)
VWFVon Willebrand factor isoform X3. (2812 aa)
FLNAfilamin-A isoform X1. (2647 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X1. (950 aa)
VEGFAVascular endothelial growth factor A isoform X5; Belongs to the PDGF/VEGF growth factor family. (451 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
TNRtenascin-R. (1358 aa)
ROCK2Rho-associated protein kinase 2 isoform X5; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1387 aa)
LAMB2Laminin subunit beta-2 isoform X1. (1801 aa)
SHC4SHC-transforming protein 4 isoform X2. (630 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
COL4A6Collagen alpha-6(IV) chain. (1706 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (1012 aa)
LAMA4Laminin subunit alpha-4 isoform X1. (1824 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
BADBcl2-associated agonist of cell death. (168 aa)
FYNTyrosine-protein kinase. (537 aa)
MYL12AMyosin regulatory light polypeptide 9 isoform X1. (178 aa)
COL4A5Collagen alpha-5(IV) chain isoform X1. (1691 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
IGF1Insulin-like growth factor 1 transcript variant X1. (186 aa)
MYLPFMyosin regulatory light chain 2, skeletal muscle isoform. (170 aa)
FN1Fibronectin isoform X1. (2467 aa)
VTNVitronectin. (479 aa)
LOC102988905Actin, cytoplasmic 1. (375 aa)
PTK2Focal adhesion kinase 1 isoform X10; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (579 aa)
LAMB3Laminin subunit beta-3. (1172 aa)
HRASGTPase HRas isoform X2. (189 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CRKLCrk-like protein. (279 aa)
CTNNB1Catenin beta-1. (783 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (672 aa)
ITGA2BIntegrin alpha-IIb isoform X6; Belongs to the integrin alpha chain family. (1034 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3. (562 aa)
COL4A1Collagen alpha-1(IV) chain. (1668 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (565 aa)
COL9A1Collagen alpha-1(IX) chain. (923 aa)
PDGFRBPlatelet-derived growth factor receptor beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1003 aa)
PXNPaxillin isoform X4. (1077 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TNCTenascin isoform X1. (2201 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ITGA3Integrin alpha-3 isoform X1; Belongs to the integrin alpha chain family. (1068 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
COL6A1Collagen alpha-1(VI) chain. (1027 aa)
COL6A2Collagen alpha-2(VI) chain isoform X1. (1027 aa)
COL1A1Collagen alpha-1(I) chain. (1463 aa)
PAK6Non-specific serine/threonine protein kinase. (676 aa)
ITGA11Integrin alpha-11 isoform X2; Belongs to the integrin alpha chain family. (1246 aa)
VCLVinculin isoform X2. (1134 aa)
TLN1Talin-1 isoform X2. (2291 aa)
FLNBfilamin-B. (2535 aa)
THBS1Thrombospondin-1. (1198 aa)
THBS3Thrombospondin-3 isoform X1. (956 aa)
ITGA1Integrin alpha-1 isoform X1; Belongs to the integrin alpha chain family. (1178 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
RAC3Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa)
XIAPE3 ubiquitin-protein ligase XIAP isoform X1. (497 aa)
COL6A3Collagen alpha-3(VI) chain isoform X5. (1235 aa)
ELK1ETS domain-containing protein Elk-1. (442 aa)
LAMA3Laminin subunit alpha-3 isoform X5. (3291 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
GRB2Growth factor receptor-bound protein 2. (136 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (783 aa)
FLNCfilamin-C isoform X4. (2720 aa)
PARVBBeta-parvin isoform X2. (365 aa)
PGFPlacenta growth factor isoform X1; Belongs to the PDGF/VEGF growth factor family. (170 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
Server load: low (24%) [HD]