STRINGSTRING
MET MET EGFR EGFR LEF1 LEF1 AFDN AFDN WASL WASL NECTIN3 NECTIN3 PARD3 PARD3 TCF7L1 TCF7L1 CSNK2A1 CSNK2A1 PTPN1 PTPN1 RAC1-2 RAC1-2 PTPRB PTPRB RAC2 RAC2 WAS WAS ERBB2 ERBB2 CDC42 CDC42 MAP3K7 MAP3K7 WASF2 WASF2 TCF7 TCF7 RHOA RHOA PTPRM PTPRM TGFBR2 TGFBR2 WASF1 WASF1 NLK NLK SNAI2 SNAI2 IGF1R IGF1R EP300 EP300 SSX2IP SSX2IP CSNK2B CSNK2B WASF3 WASF3 SNAI1 SNAI1 NECTIN4 NECTIN4 SMAD4 SMAD4 CTNNA2 CTNNA2 MAPK1 MAPK1 FARP2 FARP2 MAPK3 MAPK3 FYN FYN FGFR1 FGFR1 TCF7L2 TCF7L2 CTNNA1 CTNNA1 CDH1 CDH1 LOC102988905 LOC102988905 PTPRF PTPRF YES1 YES1 SMAD3 SMAD3 CTNNB1 CTNNB1 TJP1 TJP1 FER FER PTPN6 PTPN6 CSNK2A2 CSNK2A2 VCL VCL BAIAP2 BAIAP2 PTPRJ PTPRJ NECTIN1 NECTIN1 ACTG1 ACTG1 RAC3 RAC3 CTNNA3 CTNNA3 CTNND1 CTNND1 NECTIN2 NECTIN2 CREBBP CREBBP IQGAP1 IQGAP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
METHepatocyte growth factor receptor. (1412 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
AFDNAfadin isoform X14. (1784 aa)
WASLNeural Wiskott-Aldrich syndrome protein isoform X2. (505 aa)
NECTIN3Nectin-3 isoform X1. (549 aa)
PARD3Partitioning defective 3 homolog isoform X2. (1356 aa)
TCF7L1Transcription factor 7-like 1. (586 aa)
CSNK2A1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (428 aa)
RAC1-2Ras-related C3 botulinum toxin substrate 1. (185 aa)
PTPRBReceptor-type tyrosine-protein phosphatase beta isoform X1. (2213 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
WASwiskott-Aldrich syndrome protein. (502 aa)
ERBB2Receptor protein-tyrosine kinase. (1302 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (498 aa)
TCF7Transcription factor 7 isoform X3. (480 aa)
RHOARas homolog gene family, member A. (287 aa)
PTPRMReceptor-type tyrosine-protein phosphatase mu isoform X5. (1465 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
WASF1wiskott-Aldrich syndrome protein family member 1 isoform X3. (559 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
EP300Histone acetyltransferase p300 isoform X2. (2353 aa)
SSX2IPAfadin- and alpha-actinin-binding protein isoform X3. (587 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (249 aa)
WASF3wiskott-Aldrich syndrome protein family member 3 isoform X1. (501 aa)
SNAI1Zinc finger protein SNAI1. (264 aa)
NECTIN4Nectin-4. (509 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
CTNNA2Catenin alpha-2 isoform X1. (953 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
FARP2FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X3. (615 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
FYNTyrosine-protein kinase. (537 aa)
FGFR1Fibroblast growth factor receptor. (852 aa)
TCF7L2Transcription factor 7-like 2 isoform X4. (669 aa)
CTNNA1Catenin alpha-1. (906 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
LOC102988905Actin, cytoplasmic 1. (375 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F isoform X1. (1911 aa)
YES1Tyrosine-protein kinase. (543 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CTNNB1Catenin beta-1. (783 aa)
TJP1Tight junction protein ZO-1 isoform X2; Belongs to the MAGUK family. (1755 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
CSNK2A2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (350 aa)
VCLVinculin isoform X2. (1134 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1. (350 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta. (1152 aa)
NECTIN1Nectin-1. (516 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
RAC3Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa)
CTNNA3Catenin alpha-3 isoform X1. (895 aa)
CTNND1Catenin delta-1 isoform X1. (938 aa)
NECTIN2Nectin-2 isoform X1. (539 aa)
CREBBPCREB-binding protein. (1362 aa)
IQGAP1Ras GTPase-activating-like protein IQGAP1 isoform X1. (1631 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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