STRINGSTRING
LOC112062939 LOC112062939 TAB2 TAB2 NFKB1 NFKB1 MAPK9 MAPK9 ATG12 ATG12 NEK7 NEK7 MAPK10 MAPK10 CASP8 CASP8 NLRP3 NLRP3 RNASEL RNASEL TBK1 TBK1 MFN1 MFN1 TNFAIP3 TNFAIP3 MAPK12 MAPK12 MAPK11 MAPK11 LOC102990974 LOC102990974 IL6 IL6 NAMPT NAMPT IFNAR2 IFNAR2 IFNAR1 IFNAR1 CXCL8 CXCL8 LOC112062060 LOC112062060 PANX1 PANX1 TRAF3 TRAF3 NOD1 NOD1 SUGT1 SUGT1 ANTXR2 ANTXR2 PLCB4 PLCB4 HSP90AB1 HSP90AB1 YWHAE YWHAE CASP1 CASP1 LOC102987795 LOC102987795 CASR CASR IL1B IL1B LOC102993187 LOC102993187 BIRC2 BIRC2 AP5S1 AP5S1 TRAF2 TRAF2 TRPV2 TRPV2 TRAF5 TRAF5 GBP1 GBP1 MAPK8 MAPK8 MAP3K7 MAP3K7 TAB1 TAB1 PKN2 PKN2 BCL2 BCL2 RIPK1 RIPK1 NLRX1 NLRX1 VDAC3 VDAC3 ANTXR1 ANTXR1 NFKBIA NFKBIA NFKBIB NFKBIB VDAC1 VDAC1 PLCB1 PLCB1 RIPK2 RIPK2 CARD9 CARD9 RHOA RHOA IRF3 IRF3 NLRC4 NLRC4 TRPM7 TRPM7 ENSPCTP00005015321 ENSPCTP00005015321 TANK TANK SHARPIN SHARPIN TXNIP TXNIP DNM1L DNM1L CCL2 CCL2 LOC102986634 LOC102986634 TAB3 TAB3 ERBIN ERBIN LOC112067437 LOC112067437 TICAM1 TICAM1 TNF TNF LOC112062148 LOC112062148 TRAF6 TRAF6 CYBA CYBA OAS2 OAS2 GABARAPL2 GABARAPL2 MAPK1 MAPK1 GSDMD GSDMD GABARAP GABARAP IKBKG IKBKG MAPK3 MAPK3 TXN TXN ATG5 ATG5 IKBKE IKBKE ITPR3 ITPR3 PLCB3 PLCB3 STAT2 STAT2 TMEM173 TMEM173 CCL5 CCL5 MFN2 MFN2 LOC102973809 LOC102973809 IFNB1 IFNB1 LOC112063002 LOC112063002 LOC112065793 LOC112065793 LOC112064927 LOC112064927 LOC112065747 LOC112065747 LOC102980021 LOC102980021 LOC112065794 LOC112065794 LOC102993821 LOC102993821 IRAK4 IRAK4 LOC102992994 LOC102992994 MCU MCU CHUK CHUK IRF7 IRF7 CYBB CYBB IKBKB IKBKB MYD88 MYD88 TLR4 TLR4 RELA RELA BCL2L1 BCL2L1 PSTPIP1 PSTPIP1 MAPK14 MAPK14 CTSB CTSB JUN JUN MAPK13 MAPK13 STAT1 STAT1 ITPR2 ITPR2 ATG16L1 ATG16L1 DHX33 DHX33 P2RX7 P2RX7 TRIP6 TRIP6 VDAC2 VDAC2 TXN2 TXN2 MEFV MEFV LOC102984303 LOC102984303 TP53BP1 TP53BP1 RNF31 RNF31 IRF9 IRF9 GABARAPL1 GABARAPL1 IL18 IL18 HSP90AA1 HSP90AA1 XIAP XIAP TYK2 TYK2 PRKCD PRKCD PKN1 PKN1 JAK1 JAK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC11206293914-3-3 protein homolog; Belongs to the 14-3-3 family. (193 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2. (693 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (973 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
NEK7Serine/threonine-protein kinase Nek7 isoform X6; Belongs to the protein kinase superfamily. (336 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3. (1043 aa)
RNASEL2-5A-dependent ribonuclease isoform X1. (737 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (893 aa)
MFN1Mitofusin-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (742 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3 isoform X1. (785 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
LOC102990974Gamma-interferon-inducible protein 16-like isoform X1. (533 aa)
IL6Interleukin-6. (208 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)
IFNAR2Interferon alpha/beta receptor 2 isoform X1. (519 aa)
IFNAR1Interferon alpha/beta receptor 1. (563 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
LOC112062060Growth-regulated protein homolog beta. (104 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (427 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
SUGT1Protein SGT1 homolog. (378 aa)
ANTXR2Anthrax toxin receptor; Belongs to the ATR family. (488 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
HSP90AB1Heat shock protein HSP 90-beta. (728 aa)
YWHAE14-3-3 protein epsilon isoform X1; Belongs to the 14-3-3 family. (255 aa)
CASP1Caspase-1; Belongs to the peptidase C14A family. (404 aa)
LOC102987795Caspase-13 isoform X1; Belongs to the peptidase C14A family. (377 aa)
CASRExtracellular calcium-sensing receptor isoform X1. (1091 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
LOC102993187NACHT, LRR and PYD domains-containing protein 2. (947 aa)
BIRC2Baculoviral IAP repeat-containing protein 2 isoform X1. (621 aa)
AP5S1AP-5 complex subunit sigma-1 isoform X2. (511 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (762 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
GBP1Guanylate-binding protein 1-like. (590 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2. (504 aa)
PKN2Serine/threonine-protein kinase N2 isoform X1. (983 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (230 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (667 aa)
NLRX1NLR family member X1 isoform X1. (973 aa)
VDAC3Voltage-dependent anion-selective channel protein 3. (284 aa)
ANTXR1Anthrax toxin receptor; Belongs to the ATR family. (564 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
NFKBIBNF-kappa-B inhibitor beta. (353 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (283 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
CARD9Caspase recruitment domain-containing protein 9 isoform X1. (553 aa)
RHOARas homolog gene family, member A. (287 aa)
IRF3Interferon regulatory factor 3 isoform X2. (434 aa)
NLRC4NLR family CARD domain-containing protein 4. (1024 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7 isoform X3. (1866 aa)
ENSPCTP00005015321LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like. (119 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X2. (408 aa)
SHARPINSharpin isoform X2. (408 aa)
TXNIPThioredoxin-interacting protein. (391 aa)
DNM1LDynamin-1-like protein isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
CCL2Monocyte chemotactic protein 1B. (98 aa)
LOC102986634Apoptosis-associated speck-like protein containing a CARD. (195 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2. (717 aa)
ERBINErbin isoform X1. (1461 aa)
LOC112067437FAS-associated death domain protein isoform X1. (284 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (732 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC112062148Beta-defensin 103-like. (66 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (193 aa)
OAS22'-5'-oligoadenylate synthase 2 isoform X2. (685 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2 isoform X2. (117 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
GSDMDgasdermin-D isoform X1. (487 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
IKBKGNF-kappa-B essential modulator. (361 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
TXNThioredoxin isoform X2. (105 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (691 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
STAT2Signal transducer and activator of transcription. (903 aa)
TMEM173Stimulator of interferon genes protein isoform X2. (533 aa)
CCL5C-C motif chemokine. (91 aa)
MFN2Mitofusin-2 isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
LOC102973809Cathelicidin-1-like. (167 aa)
IFNB1Interferon beta. (186 aa)
LOC112063002Heat shock protein 90-like. (498 aa)
LOC112065793Interferon alpha-1-like. (226 aa)
LOC112064927Antibacterial protein PR-39-like. (162 aa)
LOC112065747Interferon alpha-1-like. (282 aa)
LOC102980021Interferon alpha-17-like. (171 aa)
LOC112065794Interferon alpha-1-like isoform X1. (225 aa)
LOC102993821Cathelicidin-6-like. (159 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
LOC102992994Cathelicidin-5-like. (159 aa)
MCUCalcium uniporter protein, mitochondrial. (359 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2. (744 aa)
IRF7Interferon regulatory factor 7 isoform X1. (489 aa)
CYBBCytochrome b-245 heavy chain. (570 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (771 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (304 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
RELATranscription factor p65 isoform X3. (551 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
PSTPIP1Proline-serine-threonine phosphatase-interacting protein 1 isoform X1. (416 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CTSBCathepsin B isoform X1; Belongs to the peptidase C1 family. (336 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
ATG16L1Autophagy-related protein 16-1. (379 aa)
DHX33ATP-dependent RNA helicase DHX33. (710 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
TRIP6Thyroid receptor-interacting protein 6. (488 aa)
VDAC2Voltage-dependent anion-selective channel protein 2. (294 aa)
TXN2Thioredoxin, mitochondrial isoform X1. (166 aa)
MEFVLOW QUALITY PROTEIN: pyrin. (99 aa)
LOC102984303Thioredoxin; Belongs to the thioredoxin family. (105 aa)
TP53BP1TP53-binding protein 1 isoform X1. (1974 aa)
RNF31E3 ubiquitin-protein ligase RNF31 isoform X3. (1072 aa)
IRF9Interferon regulatory factor 9. (410 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1. (141 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (733 aa)
XIAPE3 ubiquitin-protein ligase XIAP isoform X1. (497 aa)
TYK2Tyrosine-protein kinase. (1185 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
PKN1Serine/threonine-protein kinase N1 isoform X1. (956 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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