(48 nodes) Cytosolic DNA-sensing pathway network (Physeter catodon)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (973 aa)
	TBK1	Serine/threonine-protein kinase TBK1 isoform X1. (893 aa)
	IL6	Interleukin-6. (208 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	POLR2K	DNA-directed RNA polymerases I, II, and III subunit RPABC4. (58 aa)
	POLR3A	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1390 aa)
	POLR3E	DNA-directed RNA polymerase III subunit RPC5 isoform X2. (720 aa)
	POLR3G	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (223 aa)
	CASP1	Caspase-1; Belongs to the peptidase C14A family. (404 aa)
	POLR2H	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
	AP5S1	AP-5 complex subunit sigma-1 isoform X2. (511 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (667 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (314 aa)
	NFKBIB	NF-kappa-B inhibitor beta. (353 aa)
	IRF3	Interferon regulatory factor 3 isoform X2. (434 aa)
	POLR3F	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
	LOC114486504	DNA-directed RNA polymerase III subunit RPC8-like. (125 aa)
	POLR3GL	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (218 aa)
	ADAR	Double-stranded RNA-specific adenosine deaminase isoform X2. (1174 aa)
	POLR1C	DNA-directed RNA polymerases I and III subunit RPAC1 isoform X1. (347 aa)
	LOC102986634	Apoptosis-associated speck-like protein containing a CARD. (195 aa)
	POLR3C	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa)
	POLR1D	DNA-directed RNA polymerases I and III subunit RPAC2. (133 aa)
	POLR3D	DNA-directed RNA polymerase III subunit RPC4 isoform X1. (398 aa)
	IKBKG	NF-kappa-B essential modulator. (361 aa)
	IKBKE	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (691 aa)
	TMEM173	Stimulator of interferon genes protein isoform X2. (533 aa)
	CCL5	C-C motif chemokine. (91 aa)
	LOC102996463	C-C motif chemokine. (97 aa)
	POLR2L	DNA-directed RNA polymerases I, II, and III subunit RPABC5. (67 aa)
	IFNB1	Interferon beta. (186 aa)
	LOC112065793	Interferon alpha-1-like. (226 aa)
	LOC112065747	Interferon alpha-1-like. (282 aa)
	LOC102980021	Interferon alpha-17-like. (171 aa)
	LOC112065794	Interferon alpha-1-like isoform X1. (225 aa)
	POLR2F	DNA-directed RNA polymerases I, II, and III subunit RPABC2. (127 aa)
	POLR2E	DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1. (210 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2. (744 aa)
	IRF7	Interferon regulatory factor 7 isoform X1. (489 aa)
	POLR3K	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
	POLR3H	DNA-directed RNA polymerase III subunit RPC8 isoform X2. (222 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (771 aa)
	RELA	Transcription factor p65 isoform X3. (551 aa)
	POLR3B	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1133 aa)
	ZBP1	Z-DNA-binding protein 1. (358 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	CGAS	Cyclic GMP-AMP synthase. (513 aa)

Your Current Organism:

Physeter catodon

NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	IRF7	ENSPCTP00005017391	ENSPCTP00005024042	Double-stranded RNA-specific adenosine deaminase isoform X2.	Interferon regulatory factor 7 isoform X1.	0.500
AP5S1	CASP1	ENSPCTP00005011620	ENSPCTP00005010211	AP-5 complex subunit sigma-1 isoform X2.	Caspase-1; Belongs to the peptidase C14A family.	0.447
AP5S1	CCL5	ENSPCTP00005011620	ENSPCTP00005021530	AP-5 complex subunit sigma-1 isoform X2.	C-C motif chemokine.	0.429
AP5S1	CGAS	ENSPCTP00005011620	ENSPCTP00005031315	AP-5 complex subunit sigma-1 isoform X2.	Cyclic GMP-AMP synthase.	0.654
AP5S1	CHUK	ENSPCTP00005011620	ENSPCTP00005024015	AP-5 complex subunit sigma-1 isoform X2.	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2.	0.971
AP5S1	CXCL10	ENSPCTP00005011620	ENSPCTP00005007317	AP-5 complex subunit sigma-1 isoform X2.	C-X-C motif chemokine.	0.442
AP5S1	IFNB1	ENSPCTP00005011620	ENSPCTP00005022719	AP-5 complex subunit sigma-1 isoform X2.	Interferon beta.	0.715
AP5S1	IKBKB	ENSPCTP00005011620	ENSPCTP00005025351	AP-5 complex subunit sigma-1 isoform X2.	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	0.970
AP5S1	IKBKE	ENSPCTP00005011620	ENSPCTP00005020666	AP-5 complex subunit sigma-1 isoform X2.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	0.965
AP5S1	IKBKG	ENSPCTP00005011620	ENSPCTP00005020510	AP-5 complex subunit sigma-1 isoform X2.	NF-kappa-B essential modulator.	0.900
AP5S1	IL1B	ENSPCTP00005011620	ENSPCTP00005010805	AP-5 complex subunit sigma-1 isoform X2.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.454
AP5S1	IL6	ENSPCTP00005011620	ENSPCTP00005004186	AP-5 complex subunit sigma-1 isoform X2.	Interleukin-6.	0.467
AP5S1	IRF3	ENSPCTP00005011620	ENSPCTP00005014991	AP-5 complex subunit sigma-1 isoform X2.	Interferon regulatory factor 3 isoform X2.	0.939
AP5S1	IRF7	ENSPCTP00005011620	ENSPCTP00005024042	AP-5 complex subunit sigma-1 isoform X2.	Interferon regulatory factor 7 isoform X1.	0.762
AP5S1	NFKB1	ENSPCTP00005011620	ENSPCTP00005000961	AP-5 complex subunit sigma-1 isoform X2.	Nuclear factor NF-kappa-B p105 subunit isoform X1.	0.409
AP5S1	NFKBIA	ENSPCTP00005011620	ENSPCTP00005013283	AP-5 complex subunit sigma-1 isoform X2.	NF-kappa-B inhibitor alpha.	0.471
AP5S1	RIPK1	ENSPCTP00005011620	ENSPCTP00005012861	AP-5 complex subunit sigma-1 isoform X2.	Receptor-interacting serine/threonine-protein kinase 1 isoform X1.	0.730
AP5S1	TBK1	ENSPCTP00005011620	ENSPCTP00005003158	AP-5 complex subunit sigma-1 isoform X2.	Serine/threonine-protein kinase TBK1 isoform X1.	0.993
AP5S1	TMEM173	ENSPCTP00005011620	ENSPCTP00005021327	AP-5 complex subunit sigma-1 isoform X2.	Stimulator of interferon genes protein isoform X2.	0.980
CASP1	AP5S1	ENSPCTP00005010211	ENSPCTP00005011620	Caspase-1; Belongs to the peptidase C14A family.	AP-5 complex subunit sigma-1 isoform X2.	0.447