(79 nodes) Th1 and Th2 cell differentiation network (Physeter catodon)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (973 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	MAML3	Mastermind-like protein 3 isoform X1. (1088 aa)
	MAML1	Mastermind-like protein 1. (1018 aa)
	MAPK10	Mitogen-activated protein kinase. (467 aa)
	MAPK12	Mitogen-activated protein kinase. (367 aa)
	IFNGR1	Interferon gamma receptor 1. (468 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	IFNGR2	Interferon gamma receptor 2 isoform X1. (365 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	LOC102976012	HLA class II histocompatibility antigen, DQ beta 1 chain isoform X2. (295 aa)
	LOC102976287	HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X1; Belongs to the MHC class II family. (268 aa)
	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2 isoform X4. (915 aa)
	TBX21	T-box transcription factor TBX21. (535 aa)
	HLA-DRA	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (253 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	NOTCH3	Neurogenic locus notch homolog protein 3 isoform X2. (2320 aa)
	IL13	Interleukin-13. (146 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
	IL2RB	Interleukin-2 receptor subunit beta. (556 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	RUNX3	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (430 aa)
	NFKBIE	NF-kappa-B inhibitor epsilon. (362 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1236 aa)
	ZAP70	Tyrosine-protein kinase. (617 aa)
	PPP3R1	Calcineurin subunit B type 1. (188 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	DLL3	Delta-like protein 3. (587 aa)
	LOC102994605	HLA class II histocompatibility antigen, DM beta chain. (263 aa)
	LOC102988344	Nuclear factor of activated T-cells, cytoplasmic 1. (453 aa)
	HLA-DOA	HLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family. (250 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1. (2531 aa)
	STAT5B	Signal transducer and activator of transcription. (787 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (314 aa)
	NFKBIB	NF-kappa-B inhibitor beta. (353 aa)
	IL4R	Interleukin-4 receptor subunit alpha isoform X1. (833 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	LOC102980498	Recombining binding protein suppressor of hairless isoform X1. (487 aa)
	IL2RG	Cytokine receptor common subunit gamma isoform X2. (364 aa)
	MAML2	Mastermind-like protein 2. (1121 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1165 aa)
	CD3G	T-cell surface glycoprotein CD3 gamma chain. (178 aa)
	CD3D	T-cell surface glycoprotein CD3 delta chain isoform X1. (171 aa)
	MAF	Transcription factor Maf isoform X2; Belongs to the bZIP family. (368 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
	NFATC1	Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (460 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (522 aa)
	IKBKG	NF-kappa-B essential modulator. (361 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
	NFATC3	Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2. (2471 aa)
	LOC102994322	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family. (217 aa)
	IL12RB2	Interleukin-12 receptor subunit beta-2. (861 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2. (744 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (771 aa)
	FOS	Proto-oncogene c-Fos. (380 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (525 aa)
	RELA	Transcription factor p65 isoform X3. (551 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	JUN	Transcription factor AP-1; Belongs to the bZIP family. (338 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	STAT1	Signal transducer and activator of transcription. (749 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
	STAT4	Signal transducer and activator of transcription. (748 aa)
	LAT	Linker for activation of T-cells family member 1 isoform X2. (225 aa)
	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain-like. (262 aa)
	RBPJL	Recombining binding protein suppressor of hairless-like protein isoform X1. (516 aa)
	JAK3	Tyrosine-protein kinase. (1104 aa)
	IL12RB1	Interleukin-12 receptor subunit beta-1 isoform X2. (676 aa)
	TYK2	Tyrosine-protein kinase. (1185 aa)
	JAK1	Tyrosine-protein kinase. (1154 aa)

Your Current Organism:

Physeter catodon

NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD3D	CD3G	ENSPCTP00005019060	ENSPCTP00005018732	T-cell surface glycoprotein CD3 delta chain isoform X1.	T-cell surface glycoprotein CD3 gamma chain.	0.999
CD3D	HLA-DOB	ENSPCTP00005019060	ENSPCTP00005029969	T-cell surface glycoprotein CD3 delta chain isoform X1.	HLA class II histocompatibility antigen, DO beta chain-like.	0.449
CD3D	HLA-DRA	ENSPCTP00005019060	ENSPCTP00005007369	T-cell surface glycoprotein CD3 delta chain isoform X1.	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	0.463
CD3D	IL2RB	ENSPCTP00005019060	ENSPCTP00005009646	T-cell surface glycoprotein CD3 delta chain isoform X1.	Interleukin-2 receptor subunit beta.	0.481
CD3D	IL2RG	ENSPCTP00005019060	ENSPCTP00005014283	T-cell surface glycoprotein CD3 delta chain isoform X1.	Cytokine receptor common subunit gamma isoform X2.	0.419
CD3D	LAT	ENSPCTP00005019060	ENSPCTP00005029440	T-cell surface glycoprotein CD3 delta chain isoform X1.	Linker for activation of T-cells family member 1 isoform X2.	0.565
CD3D	LOC102976012	ENSPCTP00005019060	ENSPCTP00005006844	T-cell surface glycoprotein CD3 delta chain isoform X1.	HLA class II histocompatibility antigen, DQ beta 1 chain isoform X2.	0.449
CD3D	LOC102976287	ENSPCTP00005019060	ENSPCTP00005006942	T-cell surface glycoprotein CD3 delta chain isoform X1.	HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X1; Belongs to the MHC class II family.	0.463
CD3D	ZAP70	ENSPCTP00005019060	ENSPCTP00005011866	T-cell surface glycoprotein CD3 delta chain isoform X1.	Tyrosine-protein kinase.	0.980
CD3G	CD3D	ENSPCTP00005018732	ENSPCTP00005019060	T-cell surface glycoprotein CD3 gamma chain.	T-cell surface glycoprotein CD3 delta chain isoform X1.	0.999
CD3G	HLA-DOB	ENSPCTP00005018732	ENSPCTP00005029969	T-cell surface glycoprotein CD3 gamma chain.	HLA class II histocompatibility antigen, DO beta chain-like.	0.493
CD3G	HLA-DRA	ENSPCTP00005018732	ENSPCTP00005007369	T-cell surface glycoprotein CD3 gamma chain.	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	0.536
CD3G	LAT	ENSPCTP00005018732	ENSPCTP00005029440	T-cell surface glycoprotein CD3 gamma chain.	Linker for activation of T-cells family member 1 isoform X2.	0.604
CD3G	LOC102976287	ENSPCTP00005018732	ENSPCTP00005006942	T-cell surface glycoprotein CD3 gamma chain.	HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X1; Belongs to the MHC class II family.	0.400
CD3G	PLCG1	ENSPCTP00005018732	ENSPCTP00005018678	T-cell surface glycoprotein CD3 gamma chain.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.567
CD3G	PRKCQ	ENSPCTP00005018732	ENSPCTP00005006107	T-cell surface glycoprotein CD3 gamma chain.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.441
CD3G	ZAP70	ENSPCTP00005018732	ENSPCTP00005011866	T-cell surface glycoprotein CD3 gamma chain.	Tyrosine-protein kinase.	0.981
CHUK	IFNG	ENSPCTP00005024015	ENSPCTP00005004159	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.476
CHUK	IKBKB	ENSPCTP00005024015	ENSPCTP00005025351	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2.	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	0.999
CHUK	IKBKG	ENSPCTP00005024015	ENSPCTP00005020510	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2.	NF-kappa-B essential modulator.	0.984