(95 nodes) Th17 cell differentiation network (Physeter catodon)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (973 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	AHR	Aryl hydrocarbon receptor. (846 aa)
	MAPK10	Mitogen-activated protein kinase. (467 aa)
	MAPK12	Mitogen-activated protein kinase. (367 aa)
	IFNGR1	Interferon gamma receptor 1. (468 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	IL6	Interleukin-6. (208 aa)
	IL22	Interleukin-22. (180 aa)
	IFNGR2	Interferon gamma receptor 2 isoform X1. (365 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (518 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	IL17A	interleukin-17A isoform X2. (153 aa)
	IL17F	interleukin-17F isoform X1. (165 aa)
	RXRA	Retinoic acid receptor RXR-alpha. (457 aa)
	RXRG	Retinoic acid receptor RXR-gamma isoform X1. (340 aa)
	LOC102976012	HLA class II histocompatibility antigen, DQ beta 1 chain isoform X2. (295 aa)
	LOC102976287	HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X1; Belongs to the MHC class II family. (268 aa)
	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2 isoform X4. (915 aa)
	FOXP3	Forkhead box protein P3 isoform X1. (454 aa)
	TBX21	T-box transcription factor TBX21. (535 aa)
	HLA-DRA	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (253 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
	IL2RB	Interleukin-2 receptor subunit beta. (556 aa)
	HSP90AB1	Heat shock protein HSP 90-beta. (728 aa)
	NFKBIE	NF-kappa-B inhibitor epsilon. (362 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform X1. (822 aa)
	IL6ST	Interleukin-6 receptor subunit beta. (918 aa)
	ZAP70	Tyrosine-protein kinase. (617 aa)
	PPP3R1	Calcineurin subunit B type 1. (188 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	LOC102994605	HLA class II histocompatibility antigen, DM beta chain. (263 aa)
	LOC102988344	Nuclear factor of activated T-cells, cytoplasmic 1. (453 aa)
	HLA-DOA	HLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family. (250 aa)
	STAT5B	Signal transducer and activator of transcription. (787 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (314 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	NFKBIB	NF-kappa-B inhibitor beta. (353 aa)
	IL4R	Interleukin-4 receptor subunit alpha isoform X1. (833 aa)
	IL21R	Interleukin-21 receptor. (540 aa)
	STAT3	Signal transducer and activator of transcription. (801 aa)
	RORA	Nuclear receptor ROR-alpha isoform X1. (523 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (160 aa)
	IL2RG	Cytokine receptor common subunit gamma isoform X2. (364 aa)
	IL17D	interleukin-17D. (197 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
	IRF4	Interferon regulatory factor 4 isoform X1. (451 aa)
	ENSPCTP00005015321	LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like. (119 aa)
	RXRB	Retinoic acid receptor RXR-beta isoform X1. (540 aa)
	IL1R1	Interleukin-1 receptor type 1. (573 aa)
	IL6R	Interleukin-6 receptor subunit alpha. (454 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1165 aa)
	IL1RAP	Interleukin-1 receptor accessory protein isoform X2. (568 aa)
	CD3G	T-cell surface glycoprotein CD3 gamma chain. (178 aa)
	CD3D	T-cell surface glycoprotein CD3 delta chain isoform X1. (171 aa)
	SMAD4	Mothers against decapentaplegic homolog. (553 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
	NFATC1	Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (460 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (522 aa)
	IKBKG	NF-kappa-B essential modulator. (361 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
	IL23A	Interleukin-23 subunit alpha. (188 aa)
	NFATC3	Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa)
	LOC112063002	Heat shock protein 90-like. (498 aa)
	LOC102994322	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family. (217 aa)
	RARA	Retinoic acid receptor alpha isoform X4. (462 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2. (744 aa)
	IL23R	Interleukin-23 receptor isoform X1. (630 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (771 aa)
	FOS	Proto-oncogene c-Fos. (380 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (525 aa)
	RELA	Transcription factor p65 isoform X3. (551 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	JUN	Transcription factor AP-1; Belongs to the bZIP family. (338 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	STAT1	Signal transducer and activator of transcription. (749 aa)
	LAT	Linker for activation of T-cells family member 1 isoform X2. (225 aa)
	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain-like. (262 aa)
	JAK3	Tyrosine-protein kinase. (1104 aa)
	RORC	Nuclear receptor ROR-gamma isoform X1. (518 aa)
	IL12RB1	Interleukin-12 receptor subunit beta-1 isoform X2. (676 aa)
	HSP90AA1	Heat shock protein HSP 90-alpha. (733 aa)
	TYK2	Tyrosine-protein kinase. (1185 aa)
	IL27RA	Interleukin-27 receptor subunit alpha. (633 aa)
	JAK1	Tyrosine-protein kinase. (1154 aa)

Your Current Organism:

Physeter catodon

NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHR	ENSPCTP00005015321	ENSPCTP00005001916	ENSPCTP00005015321	Aryl hydrocarbon receptor.	LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like.	0.981
AHR	HSP90AA1	ENSPCTP00005001916	ENSPCTP00005030738	Aryl hydrocarbon receptor.	Heat shock protein HSP 90-alpha.	0.981
AHR	HSP90AB1	ENSPCTP00005001916	ENSPCTP00005009865	Aryl hydrocarbon receptor.	Heat shock protein HSP 90-beta.	0.988
AHR	LOC112063002	ENSPCTP00005001916	ENSPCTP00005022743	Aryl hydrocarbon receptor.	Heat shock protein 90-like.	0.981
CD3D	CD3G	ENSPCTP00005019060	ENSPCTP00005018732	T-cell surface glycoprotein CD3 delta chain isoform X1.	T-cell surface glycoprotein CD3 gamma chain.	0.999
CD3D	HLA-DOB	ENSPCTP00005019060	ENSPCTP00005029969	T-cell surface glycoprotein CD3 delta chain isoform X1.	HLA class II histocompatibility antigen, DO beta chain-like.	0.449
CD3D	HLA-DRA	ENSPCTP00005019060	ENSPCTP00005007369	T-cell surface glycoprotein CD3 delta chain isoform X1.	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	0.463
CD3D	IL2RB	ENSPCTP00005019060	ENSPCTP00005009646	T-cell surface glycoprotein CD3 delta chain isoform X1.	Interleukin-2 receptor subunit beta.	0.481
CD3D	IL2RG	ENSPCTP00005019060	ENSPCTP00005014283	T-cell surface glycoprotein CD3 delta chain isoform X1.	Cytokine receptor common subunit gamma isoform X2.	0.419
CD3D	LAT	ENSPCTP00005019060	ENSPCTP00005029440	T-cell surface glycoprotein CD3 delta chain isoform X1.	Linker for activation of T-cells family member 1 isoform X2.	0.565
CD3D	LOC102976012	ENSPCTP00005019060	ENSPCTP00005006844	T-cell surface glycoprotein CD3 delta chain isoform X1.	HLA class II histocompatibility antigen, DQ beta 1 chain isoform X2.	0.449
CD3D	LOC102976287	ENSPCTP00005019060	ENSPCTP00005006942	T-cell surface glycoprotein CD3 delta chain isoform X1.	HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X1; Belongs to the MHC class II family.	0.463
CD3D	ZAP70	ENSPCTP00005019060	ENSPCTP00005011866	T-cell surface glycoprotein CD3 delta chain isoform X1.	Tyrosine-protein kinase.	0.980
CD3G	CD3D	ENSPCTP00005018732	ENSPCTP00005019060	T-cell surface glycoprotein CD3 gamma chain.	T-cell surface glycoprotein CD3 delta chain isoform X1.	0.999
CD3G	HLA-DOB	ENSPCTP00005018732	ENSPCTP00005029969	T-cell surface glycoprotein CD3 gamma chain.	HLA class II histocompatibility antigen, DO beta chain-like.	0.493
CD3G	HLA-DRA	ENSPCTP00005018732	ENSPCTP00005007369	T-cell surface glycoprotein CD3 gamma chain.	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	0.536
CD3G	LAT	ENSPCTP00005018732	ENSPCTP00005029440	T-cell surface glycoprotein CD3 gamma chain.	Linker for activation of T-cells family member 1 isoform X2.	0.604
CD3G	LOC102976287	ENSPCTP00005018732	ENSPCTP00005006942	T-cell surface glycoprotein CD3 gamma chain.	HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X1; Belongs to the MHC class II family.	0.400
CD3G	PLCG1	ENSPCTP00005018732	ENSPCTP00005018678	T-cell surface glycoprotein CD3 gamma chain.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.567
CD3G	PRKCQ	ENSPCTP00005018732	ENSPCTP00005006107	T-cell surface glycoprotein CD3 gamma chain.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.441