STRINGSTRING
PIK3CB PIK3CB GSK3B GSK3B MAPK9 MAPK9 PPP1R3A PPP1R3A PRKCI PRKCI MAPK10 MAPK10 PRKCZ PRKCZ PIK3CA PIK3CA MTOR MTOR CBLB CBLB EIF4E1B EIF4E1B G6PC2 G6PC2 HK3 HK3 PRKAR2B PRKAR2B EIF4E EIF4E FBP2 FBP2 FBP1 FBP1 PPP1R3F PPP1R3F PRKAR1B PRKAR1B CALML5 CALML5 SREBF1 SREBF1 EXOC7 EXOC7 PTPN1 PTPN1 TSC1 TSC1 PHKG1 PHKG1 GCK GCK RAF1 RAF1 PHKA2 PHKA2 LIPE LIPE HKDC1 HKDC1 LOC114484525 LOC114484525 AKT1 AKT1 SOS1 SOS1 CRK CRK AKT2 AKT2 PPP1CB PPP1CB INS INS MAPK8 MAPK8 CBL CBL PRKAG1 PRKAG1 ARAF ARAF GYS1 GYS1 PHKB PHKB FLOT1 FLOT1 FLOT2 FLOT2 SHC3 SHC3 LOC102996886 LOC102996886 SH2B2 SH2B2 SOCS1 SOCS1 PRKAG2 PRKAG2 RHEB RHEB SOS2 SOS2 PPARGC1A PPARGC1A G6PC G6PC RHOQ RHOQ IRS1 IRS1 CALM3 CALM3 PRKAR2A PRKAR2A SHC1 SHC1 PDE3B PDE3B PHKA1 PHKA1 EIF4E2 EIF4E2 FOXO1 FOXO1 SLC2A4 SLC2A4 MAPK1 MAPK1 SHC4 SHC4 LOC112062965 LOC112062965 LOC112063146 LOC112063146 PRKACB PRKACB MAPK3 MAPK3 PPP1R3B PPP1R3B PRKAB2 PRKAB2 PIK3R1 PIK3R1 BAD BAD RPS6 RPS6 ENSPCTP00005021485 ENSPCTP00005021485 PPP1R3E PPP1R3E GYS2 GYS2 PPP1R3D PPP1R3D PRKACA PRKACA G6PC3 G6PC3 ACACB ACACB PCK1 PCK1 EIF4EBP1 EIF4EBP1 MKNK1 MKNK1 MAP2K1 MAP2K1 PTPRF PTPRF INPP5A INPP5A HRAS HRAS PIK3R3 PIK3R3 PRKAA1 PRKAA1 IKBKB IKBKB CRKL CRKL ACACA ACACA PRKAB1 PRKAB1 FASN FASN IRS2 IRS2 TSC2 TSC2 PHKG2 PHKG2 PYGM PYGM PYGL PYGL CALM2 CALM2 PDPK1 PDPK1 PKLR PKLR INPPL1 INPPL1 PPP1CC PPP1CC CALML4 CALML4 PCK2 PCK2 MKNK2 MKNK2 RPS6KB1 RPS6KB1 RPTOR RPTOR PPP1R3C PPP1R3C HK1 HK1 HK2 HK2 PIK3R2 PIK3R2 PYGB PYGB SOCS2 SOCS2 ELK1 ELK1 LOC102982336 LOC102982336 MAP2K2 MAP2K2 SOCS3 SOCS3 PRKAG3 PRKAG3 PPP1CA PPP1CA GRB2 GRB2 RPS6KB2 RPS6KB2 SOCS4 SOCS4 PRKAA2 PRKAA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A isoform X1. (1117 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
CBLBE3 ubiquitin-protein ligase CBL-B isoform X1. (983 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (251 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
HK3Hexokinase-3. (924 aa)
PRKAR2BcAMP-dependent protein kinase type II-beta regulatory subunit. (417 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
FBP2Fructose-1,6-bisphosphatase isozyme 2; Belongs to the FBPase class 1 family. (339 aa)
FBP1Fructose-1,6-bisphosphatase 1 isoform X1; Belongs to the FBPase class 1 family. (338 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F isoform X3. (795 aa)
PRKAR1BcAMP-dependent protein kinase type I-beta regulatory subunit isoform X1. (381 aa)
CALML5Calmodulin-like. (153 aa)
SREBF1Sterol regulatory element-binding protein 1 isoform X1. (1143 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (428 aa)
TSC1Hamartin isoform X2. (1166 aa)
PHKG1Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1; Belongs to the protein kinase superfamily. (387 aa)
GCKPhosphotransferase. (465 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1235 aa)
LIPEHormone-sensitive lipase isoform X1. (759 aa)
HKDC1Putative hexokinase HKDC1 isoform X11. (917 aa)
LOC114484525Phosphotransferase. (256 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (425 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CBLE3 ubiquitin-protein ligase CBL. (911 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (330 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X4. (606 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1064 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (639 aa)
SHC3SHC-transforming protein 3. (584 aa)
LOC102996886Calmodulin-like; Belongs to the calmodulin family. (83 aa)
SH2B2SH2B adapter protein 2 isoform X1. (639 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X3. (413 aa)
RHEBGTP-binding protein Rheb. (158 aa)
SOS2Son of sevenless homolog 2. (1331 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4. (796 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
RHOQRho-related GTP-binding protein RhoQ. (205 aa)
IRS1Insulin receptor substrate 1. (1245 aa)
CALM3Calmodulin-1; Belongs to the calmodulin family. (149 aa)
PRKAR2AcAMP-dependent protein kinase type II-alpha regulatory subunit isoform X1. (402 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
PDE3BPhosphodiesterase. (1117 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1226 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
FOXO1Forkhead box protein O1. (433 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
SHC4SHC-transforming protein 4 isoform X2. (630 aa)
LOC112062965cAMP-dependent protein kinase catalytic subunit beta-like. (470 aa)
LOC112063146Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (401 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily. (397 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (338 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
BADBcl2-associated agonist of cell death. (168 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
ENSPCTP00005021485CAMP-dependent protein kinase type I-alpha regulatory subunit. (179 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (702 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
ACACBacetyl-CoA carboxylase 2 isoform X1. (1777 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2. (622 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (137 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (441 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F isoform X1. (1911 aa)
INPP5AType I inositol 1,4,5-trisphosphate 5-phosphatase isoform X2. (513 aa)
HRASGTPase HRas isoform X2. (189 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (771 aa)
CRKLCrk-like protein. (279 aa)
ACACAacetyl-CoA carboxylase 1 isoform X1. (2383 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1 isoform X1. (270 aa)
FASNFatty acid synthase. (2515 aa)
IRS2Insulin receptor substrate 2 isoform X1. (1370 aa)
TSC2Tuberin isoform X4. (1817 aa)
PHKG2LOW QUALITY PROTEIN: phosphorylase b kinase gamma catalytic chain, liver/testis isoform. (374 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (533 aa)
CALM2Calmodulin-2. (82 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (565 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (573 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1264 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CALML4Calmodulin-like protein 4 isoform X1. (120 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1. (646 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (463 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RPTORRegulatory-associated protein of mTOR isoform X2. (1281 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
HK1Hexokinase-1. (786 aa)
HK2Hexokinase-2 isoform X1. (820 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (780 aa)
SOCS2Suppressor of cytokine signaling 2. (225 aa)
ELK1ETS domain-containing protein Elk-1. (442 aa)
LOC102982336LOW QUALITY PROTEIN: insulin receptor substrate 1-like. (540 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X2; Belongs to the protein kinase superfamily. (400 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3 isoform X4. (486 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
GRB2Growth factor receptor-bound protein 2. (136 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (489 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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