(87 nodes) Melanogenesis network (Physeter catodon)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GSK3B	Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
	GNAI1	Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
	ADCY1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
	GNAQ	Guanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
	LEF1	Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
	WNT9A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	FZD1	Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
	FZD3	Frizzled-3 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	DVL1	Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
	CREB3L2	Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1. (520 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	FZD7	Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	GNAI3	Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
	TCF7L1	Transcription factor 7-like 1. (586 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
	CALML5	Calmodulin-like. (153 aa)
	FZD5	Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
	EDN1	Endothelin-1. (202 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	ADCY5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1260 aa)
	TYR	Tyrosinase isoform X1. (530 aa)
	FZD4	Frizzled-4 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
	FZD9	Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	GNAI2	Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
	DCT	L-dopachrome tautomerase. (517 aa)
	ADCY6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	MITF	Microphthalmia-associated transcription factor isoform X3. (526 aa)
	TYRP1	5,6-dihydroxyindole-2-carboxylic acid oxidase isoform X1. (537 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	LOC102996886	Calmodulin-like; Belongs to the calmodulin family. (83 aa)
	TCF7	Transcription factor 7 isoform X3. (480 aa)
	ADCY7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
	FZD8	Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (678 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	EP300	Histone acetyltransferase p300 isoform X2. (2353 aa)
	CALM3	Calmodulin-1; Belongs to the calmodulin family. (149 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
	FZD2	Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
	DVL2	Segment polarity protein dishevelled homolog DVL-2 isoform X5. (732 aa)
	LOC112062965	cAMP-dependent protein kinase catalytic subunit beta-like. (470 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily. (397 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (298 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	CREB3L4	Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3. (395 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	CREB3L3	Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
	TCF7L2	Transcription factor 7-like 2 isoform X4. (669 aa)
	FZD10	Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	WNT8B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	HRAS	GTPase HRas isoform X2. (189 aa)
	GNAS	Guanine nucleotide-binding protein G(S) subunit alpha isoform X1. (395 aa)
	CTNNB1	Catenin beta-1. (783 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
	CALM2	Calmodulin-2. (82 aa)
	CALML4	Calmodulin-like protein 4 isoform X1. (120 aa)
	CREB3L1	Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
	CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
	LOC102987258	Neuroendocrine secretory protein 55-like. (241 aa)
	ASIP	Agouti-signaling protein. (133 aa)
	ADCY8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1247 aa)
	KITLG	Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
	POMC	Pro-opiomelanocortin. (260 aa)
	FZD6	Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
	DVL3	Segment polarity protein dishevelled homolog DVL-3 isoform X2. (716 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (337 aa)
	ADCY4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	CREBBP	CREB-binding protein. (1362 aa)
	ADCY9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (577 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	MAP2K2	Dual specificity mitogen-activated protein kinase kinase 2 isoform X2; Belongs to the protein kinase superfamily. (400 aa)

Your Current Organism:

Physeter catodon

NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY4	ENSPCTP00005000778	ENSPCTP00005030792	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.560
ADCY1	ADCY5	ENSPCTP00005000778	ENSPCTP00005009415	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.542
ADCY1	ADCY6	ENSPCTP00005000778	ENSPCTP00005013762	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.543
ADCY1	ADCY7	ENSPCTP00005000778	ENSPCTP00005014880	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.663
ADCY1	ADCY8	ENSPCTP00005000778	ENSPCTP00005029736	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.954
ADCY1	ADCY9	ENSPCTP00005000778	ENSPCTP00005030902	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.550
ADCY1	CALM2	ENSPCTP00005000778	ENSPCTP00005027290	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-2.	0.951
ADCY1	CALM3	ENSPCTP00005000778	ENSPCTP00005017085	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-1; Belongs to the calmodulin family.	0.951
ADCY1	CALML4	ENSPCTP00005000778	ENSPCTP00005027909	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like protein 4 isoform X1.	0.946
ADCY1	CALML5	ENSPCTP00005000778	ENSPCTP00005007229	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like.	0.951
ADCY1	CAMK2A	ENSPCTP00005000778	ENSPCTP00005028320	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily.	0.914
ADCY1	GNAI1	ENSPCTP00005000778	ENSPCTP00005000421	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1.	0.841
ADCY1	GNAI2	ENSPCTP00005000778	ENSPCTP00005011672	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I) subunit alpha-2.	0.816
ADCY1	GNAI3	ENSPCTP00005000778	ENSPCTP00005005703	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(K) subunit alpha.	0.816
ADCY1	GNAS	ENSPCTP00005000778	ENSPCTP00005025929	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(S) subunit alpha isoform X1.	0.959
ADCY1	LOC102987258	ENSPCTP00005000778	ENSPCTP00005028397	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Neuroendocrine secretory protein 55-like.	0.901
ADCY1	LOC102996886	ENSPCTP00005000778	ENSPCTP00005014161	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like; Belongs to the calmodulin family.	0.951
ADCY1	LOC112062965	ENSPCTP00005000778	ENSPCTP00005020291	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta-like.	0.923
ADCY1	PRKACA	ENSPCTP00005000778	ENSPCTP00005022748	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.923
ADCY1	PRKACB	ENSPCTP00005000778	ENSPCTP00005020506	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit beta isoform X2; Belongs to the protein kinase superfamily.	0.929