STRINGSTRING
PIK3CB PIK3CB GSK3B GSK3B NFKB1 NFKB1 GFPT2 GFPT2 MAPK9 MAPK9 PPP1R3A PPP1R3A PPARA PPARA SLC2A2 SLC2A2 MAPK10 MAPK10 PRKCZ PRKCZ RPS6KA2 RPS6KA2 PIK3CA PIK3CA MTOR MTOR CREB3L2 CREB3L2 IL6 IL6 SLC27A6 SLC27A6 G6PC2 G6PC2 PRKCQ PRKCQ CREB1 CREB1 SREBF1 SREBF1 PTPN1 PTPN1 LOC102973323 LOC102973323 AKT1 AKT1 AKT2 AKT2 PRKCB PRKCB PPP1CB PPP1CB INS INS TBC1D4 TBC1D4 MAPK8 MAPK8 PRKAG1 PRKAG1 GYS1 GYS1 NFKBIA NFKBIA GFPT1 GFPT1 STAT3 STAT3 AGT AGT PRKAG2 PRKAG2 PRKCE PRKCE PPARGC1A PPARGC1A G6PC G6PC IRS1 IRS1 PTPN11 PTPN11 SLC27A2 SLC27A2 FOXO1 FOXO1 TNF TNF RPS6KA3 RPS6KA3 SLC2A4 SLC2A4 TNFRSF1A TNFRSF1A ENSPCTP00005019549 ENSPCTP00005019549 NOS3 NOS3 SLC27A5 SLC27A5 LOC112063146 LOC112063146 PPP1R3B PPP1R3B LOC102992378 LOC102992378 PRKAB2 PRKAB2 PIK3R1 PIK3R1 PPP1R3E PPP1R3E PPARGC1B PPARGC1B GYS2 GYS2 CREB3L4 CREB3L4 PPP1R3D PPP1R3D CRTC2 CRTC2 SLC27A3 SLC27A3 CREB3L3 CREB3L3 G6PC3 G6PC3 NR1H2 NR1H2 LOC112062676 LOC112062676 LOC112062671 LOC112062671 ACACB ACACB RPS6KA1 RPS6KA1 PCK1 PCK1 PTPRF PTPRF RPS6KA6 RPS6KA6 PIK3R3 PIK3R3 PRKAA1 PRKAA1 IKBKB IKBKB PRKAB1 PRKAB1 IRS2 IRS2 RELA RELA OGA OGA PYGM PYGM PYGL PYGL SLC2A1 SLC2A1 PDPK1 PDPK1 NR1H3 NR1H3 PTEN PTEN PPP1CC PPP1CC CREB3L1 CREB3L1 PTPA PTPA TRIB3 TRIB3 PCK2 PCK2 RPS6KB1 RPS6KB1 PPP1R3C PPP1R3C SLC27A1 SLC27A1 PIK3R2 PIK3R2 SLC27A4 SLC27A4 CPT1B CPT1B PYGB PYGB PRKCD PRKCD SOCS3 SOCS3 PRKAG3 PRKAG3 PPP1CA PPP1CA RPS6KB2 RPS6KB2 PRKAA2 PRKAA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (973 aa)
GFPT2Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X1. (697 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A isoform X1. (1117 aa)
PPARAPeroxisome proliferator-activated receptor alpha isoform X1. (506 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1. (520 aa)
IL6Interleukin-6. (208 aa)
SLC27A6Long-chain fatty acid transport protein 6. (634 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
SREBF1Sterol regulatory element-binding protein 1 isoform X1. (1143 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (428 aa)
LOC102973323Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (425 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
TBC1D4TBC1 domain family member 4 isoform X1. (1300 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (330 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
GFPT1Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform X1. (703 aa)
STAT3Signal transducer and activator of transcription. (801 aa)
AGTAngiotensinogen; Belongs to the serpin family. (517 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X3. (413 aa)
PRKCENon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (219 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4. (796 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
IRS1Insulin receptor substrate 1. (1245 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SLC27A2Very long-chain acyl-CoA synthetase isoform X1. (620 aa)
FOXO1Forkhead box protein O1. (433 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A isoform X1. (442 aa)
ENSPCTP00005019549Protein O-GlcNAc transferase. (211 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1200 aa)
SLC27A5Bile acyl-CoA synthetase isoform X1. (645 aa)
LOC112063146Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (401 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (338 aa)
LOC102992378Carnitine O-palmitoyltransferase 1, liver isoform isoform X2; Belongs to the carnitine/choline acetyltransferase family. (339 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
PPARGC1BPeroxisome proliferator-activated receptor gamma coactivator 1-beta. (946 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (702 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3. (395 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
CRTC2CREB-regulated transcription coactivator 2 isoform X4. (748 aa)
SLC27A3Solute carrier family 27 member 3 isoform X2. (675 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
NR1H2Oxysterols receptor LXR-beta isoform X1. (448 aa)
LOC112062676Protein O-GlcNAc transferase. (924 aa)
LOC112062671UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit-like. (630 aa)
ACACBacetyl-CoA carboxylase 2 isoform X1. (1777 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2. (622 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F isoform X1. (1911 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (771 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1 isoform X1. (270 aa)
IRS2Insulin receptor substrate 2 isoform X1. (1370 aa)
RELATranscription factor p65 isoform X3. (551 aa)
OGAProtein O-GlcNAcase. (849 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (533 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (534 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (565 aa)
NR1H3Oxysterols receptor LXR-alpha isoform X1. (402 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PTPASerine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (304 aa)
TRIB3Tribbles homolog 3-like. (328 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1. (646 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
SLC27A1Long-chain fatty acid transport protein 1 isoform X3. (646 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
SLC27A4Long-chain fatty acid transport protein 4. (450 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform isoform X2; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (780 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3 isoform X4. (486 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (489 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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