STRINGSTRING
LOC112062897 LOC112062897 PIK3CB PIK3CB LOC102978471 LOC102978471 TAB2 TAB2 NFKB1 NFKB1 MAPK9 MAPK9 MAPK10 MAPK10 SAP30L SAP30L CASP8 CASP8 TBK1 TBK1 PSMC2 PSMC2 POLK POLK PIK3CA PIK3CA TNFAIP3 TNFAIP3 MAPK12 MAPK12 MAPK11 MAPK11 CDK6 CDK6 IL6 IL6 SAP30 SAP30 TLR2 TLR2 IFNAR2 IFNAR2 IFNAR1 IFNAR1 MDM2 MDM2 LOC102977457 LOC102977457 LOC102980508 LOC102980508 TRAF3 TRAF3 NEDD4 NEDD4 LOC102976012 LOC102976012 LOC102976287 LOC102976287 CCND3 CCND3 CXCL10 CXCL10 HLA-DRA HLA-DRA LOC102975528 LOC102975528 RAC1-2 RAC1-2 CIR1 CIR1 BTK BTK CDK2 CDK2 AKT1 AKT1 RUNX3 RUNX3 LYN LYN CCNE2 CCNE2 NFKBIE NFKBIE APAF1 APAF1 VIM VIM AKT2 AKT2 CCNA2 CCNA2 MAP2K6 MAP2K6 AP5S1 AP5S1 TRAF2 TRAF2 TRAF5 TRAF5 MAPK8 MAPK8 MAP3K7 MAP3K7 USP7 USP7 TAB1 TAB1 LOC102994605 LOC102994605 BCL2 BCL2 RIPK1 RIPK1 BCL2L11 BCL2L11 HLA-DOA HLA-DOA NFKBIA NFKBIA MAP2K7 MAP2K7 NFKBIB NFKBIB STAT3 STAT3 CASP3 CASP3 LOC102980498 LOC102980498 PSMD3 PSMD3 SYK SYK IRF3 IRF3 MAP2K4 MAP2K4 CD40 CD40 PSMD14 PSMD14 CD44 CD44 CR2 CR2 HES1 HES1 PSMD11 PSMD11 CCND2 CCND2 PSMC1 PSMC1 CCND1 CCND1 LOC112064291 LOC112064291 PSMC5 PSMC5 LOC112067437 LOC112067437 PSMD6 PSMD6 CD3G CD3G LOC102991021 LOC102991021 TNF TNF CD3D CD3D TRAF6 TRAF6 OAS2 OAS2 BAK1 BAK1 ADRM1 ADRM1 TP53 TP53 GADD45A GADD45A IKBKG IKBKG HDAC2 HDAC2 IKBKE IKBKE ISG15 ISG15 LOC114485514 LOC114485514 MAP3K14 MAP3K14 PIK3R1 PIK3R1 STAT2 STAT2 EIF2AK2 EIF2AK2 NCOR2 NCOR2 LOC112062997 LOC112062997 HDAC1 HDAC1 LOC112063874 LOC112063874 IFNB1 IFNB1 MYC MYC LOC112065793 LOC112065793 LOC112065747 LOC112065747 LOC102980021 LOC102980021 LOC102994322 LOC102994322 LOC112065794 LOC112065794 IRAK4 IRAK4 TAPBP TAPBP PSMD12 PSMD12 LOC102986675 LOC102986675 LOC102985933 LOC102985933 E2F3 E2F3 CHUK CHUK IRF7 IRF7 PSMD1 PSMD1 PLCG2 PLCG2 ENTPD8 ENTPD8 CCNE1 CCNE1 RB1 RB1 ICAM1 ICAM1 E2F1 E2F1 SIN3A SIN3A PIK3R3 PIK3R3 IKBKB IKBKB ENTPD3 ENTPD3 PSMD8 PSMD8 MYD88 MYD88 PSMC4 PSMC4 CD58 CD58 PSMD7 PSMD7 RELB RELB RELA RELA CDKN1B CDKN1B PSMD13 PSMD13 GADD45G GADD45G MAPK14 MAPK14 GADD45B GADD45B JUN JUN MAPK13 MAPK13 CALR CALR STAT1 STAT1 NFKB2 NFKB2 CDKN1A CDKN1A LOC102978194 LOC102978194 FAS FAS CDK4 CDK4 E2F2 E2F2 CD19 CD19 PDIA3 PDIA3 CCNA1 CCNA1 HLA-DOB HLA-DOB CASP9 CASP9 TAP2 TAP2 TAP1 TAP1 IRF9 IRF9 RBPJL RBPJL PIK3R2 PIK3R2 JAK3 JAK3 DDB2 DDB2 ITGAL ITGAL IRAK1 IRAK1 TYK2 TYK2 ENTPD1 ENTPD1 BLNK BLNK PSMC6 PSMC6 JAK1 JAK1 SNW1 SNW1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC112062897Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (476 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC102978471Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2. (693 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (973 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
SAP30LHistone deacetylase complex subunit SAP30L isoform X1. (182 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (893 aa)
PSMC226S proteasome regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
POLKDNA polymerase kappa isoform X1. (878 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3 isoform X1. (785 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
IL6Interleukin-6. (208 aa)
SAP30Histone deacetylase complex subunit SAP30. (222 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (739 aa)
IFNAR2Interferon alpha/beta receptor 2 isoform X1. (519 aa)
IFNAR1Interferon alpha/beta receptor 1. (563 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
LOC102977457Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC10298050826S proteasome complex subunit SEM1 isoform X3. (70 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform X1. (1318 aa)
LOC102976012HLA class II histocompatibility antigen, DQ beta 1 chain isoform X2. (295 aa)
LOC102976287HLA class II histocompatibility antigen, DQ alpha 2 chain isoform X1; Belongs to the MHC class II family. (268 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (358 aa)
CXCL10C-X-C motif chemokine. (98 aa)
HLA-DRAHLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (253 aa)
LOC102975528Caspase-3-like; Belongs to the peptidase C14A family. (277 aa)
RAC1-2Ras-related C3 botulinum toxin substrate 1. (185 aa)
CIR1Corepressor interacting with RBPJ 1. (438 aa)
BTKTyrosine-protein kinase. (692 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (430 aa)
LYNTyrosine-protein kinase. (512 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa)
NFKBIENF-kappa-B inhibitor epsilon. (362 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (425 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (432 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (334 aa)
AP5S1AP-5 complex subunit sigma-1 isoform X2. (511 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (923 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2. (504 aa)
LOC102994605HLA class II histocompatibility antigen, DM beta chain. (263 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (230 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (667 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (196 aa)
HLA-DOAHLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family. (250 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X3. (435 aa)
NFKBIBNF-kappa-B inhibitor beta. (353 aa)
STAT3Signal transducer and activator of transcription. (801 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (277 aa)
LOC102980498Recombining binding protein suppressor of hairless isoform X1. (487 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
SYKTyrosine-protein kinase. (627 aa)
IRF3Interferon regulatory factor 3 isoform X2. (434 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (410 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (235 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14 isoform X1. (318 aa)
CD44CD44 antigen isoform X1. (785 aa)
CR2Complement receptor type 2 isoform X3. (1093 aa)
HES1Transcription factor HES-1. (280 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11 isoform X1. (422 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
PSMC126S proteasome regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
LOC112064291BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X2; Belongs to the MHC class I family. (365 aa)
PSMC526S proteasome regulatory subunit 8 isoform X1; Belongs to the AAA ATPase family. (406 aa)
LOC112067437FAS-associated death domain protein isoform X1. (284 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6 isoform X2. (389 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (178 aa)
LOC102991021S-phase kinase-associated protein 2 isoform X1. (94 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CD3DT-cell surface glycoprotein CD3 delta chain isoform X1. (171 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
OAS22'-5'-oligoadenylate synthase 2 isoform X2. (685 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
ADRM1Proteasomal ubiquitin receptor ADRM1 isoform X1. (410 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
IKBKGNF-kappa-B essential modulator. (361 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (691 aa)
ISG15Ubiquitin-like protein ISG15. (166 aa)
LOC11448551426S proteasome non-ATPase regulatory subunit 2-like. (428 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14 isoform X1. (954 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
STAT2Signal transducer and activator of transcription. (903 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase. (539 aa)
NCOR2Nuclear receptor corepressor 2 isoform X1. (2295 aa)
LOC112062997Probable 26S proteasome regulatory subunit 10B; Belongs to the AAA ATPase family. (203 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (422 aa)
LOC112063874Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
IFNB1Interferon beta. (186 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
LOC112065793Interferon alpha-1-like. (226 aa)
LOC112065747Interferon alpha-1-like. (282 aa)
LOC102980021Interferon alpha-17-like. (171 aa)
LOC102994322HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family. (217 aa)
LOC112065794Interferon alpha-1-like isoform X1. (225 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
TAPBPTapasin isoform X1. (497 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform X1. (425 aa)
LOC102986675Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC102985933H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1; Belongs to the MHC class I family. (411 aa)
E2F3Transcription factor E2F3 isoform X1. (467 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2. (744 aa)
IRF7Interferon regulatory factor 7 isoform X1. (489 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8 isoform X1; Belongs to the GDA1/CD39 NTPase family. (494 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
RB1Retinoblastoma-associated protein isoform X2. (929 aa)
ICAM1Intercellular adhesion molecule 1. (551 aa)
E2F1Transcription factor E2F1 isoform X2. (437 aa)
SIN3APaired amphipathic helix protein Sin3a isoform X1. (1274 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (771 aa)
ENTPD3Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8 isoform X1. (351 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (304 aa)
PSMC426S proteasome regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
CD58Lymphocyte function-associated antigen 3. (242 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (322 aa)
RELBTranscription factor RelB. (449 aa)
RELATranscription factor p65 isoform X3. (551 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
CALRCalreticulin. (417 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit isoform X1. (901 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
LOC102978194Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X4. (334 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (303 aa)
E2F2Transcription factor E2F2. (299 aa)
CD19B-lymphocyte antigen CD19. (565 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (421 aa)
HLA-DOBHLA class II histocompatibility antigen, DO beta chain-like. (262 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (452 aa)
TAP2Antigen peptide transporter 2. (720 aa)
TAP1Antigen peptide transporter 1. (750 aa)
IRF9Interferon regulatory factor 9. (410 aa)
RBPJLRecombining binding protein suppressor of hairless-like protein isoform X1. (516 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
DDB2DNA damage-binding protein 2 isoform X2. (426 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1001 aa)
IRAK1Interleukin-1 receptor-associated kinase 1 isoform X2. (709 aa)
TYK2Tyrosine-protein kinase. (1185 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1 isoform X1; Belongs to the GDA1/CD39 NTPase family. (513 aa)
BLNKB-cell linker protein. (459 aa)
PSMC626S proteasome regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
SNW1SNW domain-containing protein 1. (578 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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