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PIK3CB PIK3CB MET MET GAB1 GAB1 FH FH RAP1A RAP1A PIK3CA PIK3CA TGFB2 TGFB2 CUL2 CUL2 RAP1B RAP1B PAK2 PAK2 HGF HGF RAC1-2 RAC1-2 EGLN2 EGLN2 RAF1 RAF1 TFE3 TFE3 PAK5 PAK5 AKT1 AKT1 SOS1 SOS1 CRK CRK VHL VHL HIF1A HIF1A AKT2 AKT2 EGLN3 EGLN3 CDC42 CDC42 PAK1 PAK1 ARAF ARAF ARNT ARNT PRCC PRCC ETS1 ETS1 TGFA TGFA SOS2 SOS2 ELOC ELOC EPAS1 EPAS1 EGLN1 EGLN1 RBX1 RBX1 EP300 EP300 PTPN11 PTPN11 PDGFB PDGFB VEGFA VEGFA MAPK1 MAPK1 LOC102995227 LOC102995227 MAPK3 MAPK3 PIK3R1 PIK3R1 BAD BAD TGFB3 TGFB3 PAK4 PAK4 TGFB1 TGFB1 MAP2K1 MAP2K1 HRAS HRAS PIK3R3 PIK3R3 CRKL CRKL JUN JUN SLC2A1 SLC2A1 CDKN1A CDKN1A ELOB ELOB PAK6 PAK6 ARNT2 ARNT2 PIK3R2 PIK3R2 CREBBP CREBBP MAP2K2 MAP2K2 GRB2 GRB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
METHepatocyte growth factor receptor. (1412 aa)
GAB1GRB2-associated-binding protein 1 isoform X7. (724 aa)
FHFumarate hydratase, mitochondrial. (510 aa)
RAP1ARas-related protein Rap-1A isoform X1. (184 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CUL2Cullin-2 isoform X1; Belongs to the cullin family. (745 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
RAC1-2Ras-related C3 botulinum toxin substrate 1. (185 aa)
EGLN2Egl nine homolog 2. (401 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
TFE3Transcription factor E3 isoform X2. (575 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
VHLVon Hippel-Lindau disease tumor suppressor isoform X1. (166 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (822 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (425 aa)
EGLN3Egl nine homolog 3. (239 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X4. (606 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (790 aa)
PRCCProline-rich protein PRCC. (492 aa)
ETS1Protein C-ets-1. (413 aa)
TGFAProtransforming growth factor alpha isoform X1. (160 aa)
SOS2Son of sevenless homolog 2. (1331 aa)
ELOCelongin-C isoform X1; Belongs to the SKP1 family. (112 aa)
EPAS1Endothelial PAS domain-containing protein 1. (860 aa)
EGLN1Egl nine homolog 1 isoform X1. (437 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X1. (108 aa)
EP300Histone acetyltransferase p300 isoform X2. (2353 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X2; Belongs to the PDGF/VEGF growth factor family. (240 aa)
VEGFAVascular endothelial growth factor A isoform X5; Belongs to the PDGF/VEGF growth factor family. (451 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
LOC102995227Folliculin isoform X1. (478 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
BADBcl2-associated agonist of cell death. (168 aa)
TGFB3Transforming growth factor beta-3 proprotein. (456 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
HRASGTPase HRas isoform X2. (189 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CRKLCrk-like protein. (279 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (534 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
ELOBelongin-B. (118 aa)
PAK6Non-specific serine/threonine protein kinase. (676 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (717 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
CREBBPCREB-binding protein. (1362 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X2; Belongs to the protein kinase superfamily. (400 aa)
GRB2Growth factor receptor-bound protein 2. (136 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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