STRINGSTRING
PIK3CB PIK3CB GSK3B GSK3B PDGFC PDGFC NFKB1 NFKB1 EGFR EGFR LEF1 LEF1 PIK3CA PIK3CA MTOR MTOR CREB3L2 CREB3L2 EGF EGF ZEB1 ZEB1 MDM2 MDM2 TCF7L1 TCF7L1 PDGFA PDGFA CREB1 CREB1 PDGFRA PDGFRA ERG-2 ERG-2 RAF1 RAF1 CDK2 CDK2 AKT1 AKT1 SOS1 SOS1 HSP90AB1 HSP90AB1 CCNE2 CCNE2 ERBB2 ERBB2 AR AR TMPRSS2 TMPRSS2 PDGFD PDGFD MMP3 MMP3 AKT2 AKT2 INS INS ARAF ARAF BCL2 BCL2 ETV5 ETV5 INSRR INSRR NFKBIA NFKBIA SRD5A2 SRD5A2 TCF7 TCF7 ENSPCTP00005015321 ENSPCTP00005015321 TGFA TGFA SOS2 SOS2 GSTP1 GSTP1 IGF1R IGF1R EP300 EP300 MMP9 MMP9 CCND1 CCND1 IL1R2 IL1R2 PDGFB PDGFB FOXO1 FOXO1 MAPK1 MAPK1 ATF4 ATF4 TP53 TP53 IKBKG IKBKG MAPK3 MAPK3 PIK3R1 PIK3R1 BAD BAD NKX3-1 NKX3-1 CREB3L4 CREB3L4 FGFR1 FGFR1 LOC112063002 LOC112063002 CREB3L3 CREB3L3 IGF1 IGF1 TCF7L2 TCF7L2 E2F3 E2F3 CHUK CHUK MAP2K1 MAP2K1 CCNE1 CCNE1 RB1 RB1 E2F1 E2F1 HRAS HRAS PIK3R3 PIK3R3 IKBKB IKBKB HSP90B1 HSP90B1 CTNNB1 CTNNB1 RELA RELA CDKN1B CDKN1B ENSPCTP00005027176 ENSPCTP00005027176 PDPK1 PDPK1 SPINT1 SPINT1 PDGFRB PDGFRB PTEN PTEN PLAU PLAU CDKN1A CDKN1A CREB3L1 CREB3L1 E2F2 E2F2 PLAT PLAT CASP9 CASP9 PIK3R2 PIK3R2 HSP90AA1 HSP90AA1 CREBBP CREBBP FGFR2 FGFR2 MAP2K2 MAP2K2 GRB2 GRB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
PDGFCPlatelet-derived growth factor C isoform X1. (380 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (973 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1. (520 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1206 aa)
ZEB1Zinc finger E-box-binding homeobox 1 isoform X2. (1125 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
TCF7L1Transcription factor 7-like 1. (586 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (158 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
ERG-2Transcriptional regulator ERG isoform X1. (78 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
HSP90AB1Heat shock protein HSP 90-beta. (728 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa)
ERBB2Receptor protein-tyrosine kinase. (1302 aa)
ARAndrogen receptor isoform X1. (892 aa)
TMPRSS2Transmembrane protease serine 2; Belongs to the peptidase S1 family. (524 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (370 aa)
MMP3Stromelysin-1. (479 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (425 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X4. (606 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (230 aa)
ETV5ETS translocation variant 5. (510 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (254 aa)
TCF7Transcription factor 7 isoform X3. (480 aa)
ENSPCTP00005015321LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like. (119 aa)
TGFAProtransforming growth factor alpha isoform X1. (160 aa)
SOS2Son of sevenless homolog 2. (1331 aa)
GSTP1Glutathione S-transferase P; Belongs to the GST superfamily. (208 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
EP300Histone acetyltransferase p300 isoform X2. (2353 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
IL1R2Interleukin-1 receptor type 2. (392 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X2; Belongs to the PDGF/VEGF growth factor family. (240 aa)
FOXO1Forkhead box protein O1. (433 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (352 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
IKBKGNF-kappa-B essential modulator. (361 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
BADBcl2-associated agonist of cell death. (168 aa)
NKX3-1Homeobox protein Nkx-3.1. (158 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3. (395 aa)
FGFR1Fibroblast growth factor receptor. (852 aa)
LOC112063002Heat shock protein 90-like. (498 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
IGF1Insulin-like growth factor 1 transcript variant X1. (186 aa)
TCF7L2Transcription factor 7-like 2 isoform X4. (669 aa)
E2F3Transcription factor E2F3 isoform X1. (467 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2. (744 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
RB1Retinoblastoma-associated protein isoform X2. (929 aa)
E2F1Transcription factor E2F1 isoform X2. (437 aa)
HRASGTPase HRas isoform X2. (189 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (771 aa)
HSP90B1Endoplasmin. (805 aa)
CTNNB1Catenin beta-1. (783 aa)
RELATranscription factor p65 isoform X3. (551 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
ENSPCTP00005027176Glutathione S-transferase P. (203 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (565 aa)
SPINT1Kunitz-type protease inhibitor 1 isoform X1. (515 aa)
PDGFRBPlatelet-derived growth factor receptor beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1003 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PLAUUrokinase-type plasminogen activator isoform X1. (430 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
E2F2Transcription factor E2F2. (299 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (511 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (452 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (733 aa)
CREBBPCREB-binding protein. (1362 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X2; Belongs to the protein kinase superfamily. (400 aa)
GRB2Growth factor receptor-bound protein 2. (136 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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