STRINGSTRING
PIK3CB PIK3CB NFKB1 NFKB1 LEF1 LEF1 PIK3CA PIK3CA MTOR MTOR RUNX1 RUNX1 ITGAM ITGAM TCF7L1 TCF7L1 KIT KIT CSF2 CSF2 RAF1 RAF1 PIM2 PIM2 AKT1 AKT1 SOS1 SOS1 AKT2 AKT2 CCNA2 CCNA2 RUNX1T1 RUNX1T1 ARAF ARAF STAT5B STAT5B STAT3 STAT3 TCF7 TCF7 MPO MPO PER2 PER2 SOS2 SOS2 CCND1 CCND1 JUP JUP MAPK1 MAPK1 FLT3 FLT3 CEBPA CEBPA IKBKG IKBKG MAPK3 MAPK3 PML PML PIK3R1 PIK3R1 BAD BAD MYC MYC TCF7L2 TCF7L2 RARA RARA CHUK CHUK EIF4EBP1 EIF4EBP1 MAP2K1 MAP2K1 CEBPE CEBPE HRAS HRAS PIK3R3 PIK3R3 SPI1 SPI1 IKBKB IKBKB RELA RELA CD14 CD14 PIM1 PIM1 BCL2A1 BCL2A1 RPS6KB1 RPS6KB1 CCNA1 CCNA1 DUSP6 DUSP6 PIK3R2 PIK3R2 LOC102996862 LOC102996862 MAP2K2 MAP2K2 PPARD PPARD GRB2 GRB2 RPS6KB2 RPS6KB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (973 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (518 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (914 aa)
TCF7L1Transcription factor 7-like 1. (586 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (425 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (432 aa)
RUNX1T1Protein CBFA2T1 isoform X1. (662 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X4. (606 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
STAT3Signal transducer and activator of transcription. (801 aa)
TCF7Transcription factor 7 isoform X3. (480 aa)
MPOMyeloperoxidase. (747 aa)
PER2Period circadian protein homolog 2 isoform X1. (1207 aa)
SOS2Son of sevenless homolog 2. (1331 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
JUPJunction plakoglobin. (638 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
CEBPACCAAT/enhancer-binding protein alpha. (356 aa)
IKBKGNF-kappa-B essential modulator. (361 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PMLProtein PML isoform X1. (870 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
BADBcl2-associated agonist of cell death. (168 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
TCF7L2Transcription factor 7-like 2 isoform X4. (669 aa)
RARARetinoic acid receptor alpha isoform X4. (462 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2. (744 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (137 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
HRASGTPase HRas isoform X2. (189 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
SPI1Transcription factor PU.1 isoform X1. (271 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (771 aa)
RELATranscription factor p65 isoform X3. (551 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
BCL2A1Bcl-2-related protein A1. (175 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (421 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
LOC102996862Receptor protein-tyrosine kinase. (306 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X2; Belongs to the protein kinase superfamily. (400 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
GRB2Growth factor receptor-bound protein 2. (136 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (489 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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