STRINGSTRING
GOT2 GOT2 GOT1 GOT1 HKDC1 HKDC1 LDHB LDHB PGLS PGLS IDH3B IDH3B ME2 ME2 SDHD SDHD G3SR49_LOXAF G3SR49_LOXAF PDHB PDHB PKLR PKLR PARP6 PARP6 IDH3A IDH3A LDHAL6B LDHAL6B PARP8 PARP8 RPIA RPIA PDK1 PDK1 PGM2 PGM2 ME1 ME1 TKTL1 TKTL1 G6PC3 G6PC3 MDH2 MDH2 TKT TKT TALDO1 TALDO1 ENO2 ENO2 FH FH ACO2 ACO2 G6PC2 G6PC2 NIT2 NIT2 DBT DBT RBKS RBKS GCKR GCKR ME3 ME3 IDH3G IDH3G ACLY ACLY DDO DDO ENO1 ENO1 RBM45 RBM45 PFKFB2 PFKFB2 G3T180_LOXAF G3T180_LOXAF BPGM BPGM SDHC SDHC PDHA2 PDHA2 PGK2 PGK2 OGDHL OGDHL XYLB XYLB PFKP PFKP PCK1 PCK1 PNMA8B PNMA8B ALDOB ALDOB ALDOC ALDOC PGD PGD DLAT DLAT PFKM PFKM IDH2 IDH2 ADPGK ADPGK FBP2 FBP2 FBP1 FBP1 G6PD G6PD GAPDHS GAPDHS BCKDHB BCKDHB LOC100668729 LOC100668729 PGK1 PGK1 DHTKD1 DHTKD1 BCAT2 BCAT2 HK2 HK2 ENO4 ENO4 DLST DLST PDHX PDHX OGDH OGDH GPI GPI G6PC G6PC SUCLG1 SUCLG1 CS CS DERA DERA SUCLG2 SUCLG2 PCK2 PCK2 GCDH GCDH MDH1 MDH1 IDH1 IDH1 TIGAR TIGAR PFKFB4 PFKFB4 GNE GNE H6PD H6PD ALDOA ALDOA PKM PKM BCAT1 BCAT1 PFKFB1 PFKFB1 SDHA SDHA SDHB SDHB GCK GCK BCKDK BCKDK RPE RPE PDK3 PDK3 TPI1 TPI1 SUCLA2 SUCLA2 ACO1 ACO1 PFKFB3 PFKFB3 G3TZZ7_LOXAF G3TZZ7_LOXAF MYCBPAP MYCBPAP ENO3 ENO3 HK1 HK1 GPT GPT G3U8F6_LOXAF G3U8F6_LOXAF TKTL2 TKTL2 BCKDHA BCKDHA GOT1L1 GOT1L1 PGAM4 PGAM4 PGAM2 PGAM2 SORD SORD PFKL PFKL PDHA1 PDHA1 PDK2 PDK2 DLD DLD GPT2 GPT2 MPST MPST G3UNL7_LOXAF G3UNL7_LOXAF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GOT2Aspartate aminotransferase. (411 aa)
GOT1Aspartate aminotransferase. (413 aa)
HKDC1Hexokinase domain containing 1. (918 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (333 aa)
PGLS6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (258 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
ME2Malic enzyme. (584 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (156 aa)
G3SR49_LOXAFGlyceraldehyde-3-phosphate dehydrogenase. (325 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
PARP6Poly [ADP-ribose] polymerase. (628 aa)
IDH3AIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (366 aa)
LDHAL6BL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
PARP8Poly [ADP-ribose] polymerase. (892 aa)
RPIARibose 5-phosphate isomerase A. (310 aa)
PDK1Protein-serine/threonine kinase. (389 aa)
PGM2Phosphoglucomutase 2. (616 aa)
ME1Malic enzyme. (572 aa)
TKTL1Transket_pyr domain-containing protein. (626 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
MDH2Malate dehydrogenase. (338 aa)
TKTTransketolase. (611 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (305 aa)
ENO2Enolase 2. (433 aa)
FHFumarate hydratase. (508 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (779 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
NIT2Nitrilase family member 2. (276 aa)
DBTDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)
RBKSRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (322 aa)
GCKRGlucokinase regulator. (621 aa)
ME3Malic enzyme. (604 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (393 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
DDOD-aspartate oxidase. (341 aa)
ENO1Enolase 1. (434 aa)
RBM45RNA binding motif protein 45. (389 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (488 aa)
G3T180_LOXAFL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (336 aa)
BPGMPhosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (259 aa)
SDHCSuccinate dehydrogenase complex subunit C. (169 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (392 aa)
PGK2Phosphoglycerate kinase. (417 aa)
OGDHLOxoglutarate dehydrogenase like. (1011 aa)
XYLBXylulokinase. (318 aa)
PFKPPFK domain-containing protein. (231 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (624 aa)
PNMA8BUncharacterized protein. (360 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (365 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (365 aa)
PGD6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (481 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (415 aa)
ADPGKADP dependent glucokinase. (488 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
GAPDHSGlyceraldehyde-3-phosphate dehydrogenase. (445 aa)
BCKDHBBranched chain keto acid dehydrogenase E1 subunit beta. (349 aa)
LOC100668729L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
PGK1Phosphoglycerate kinase. (417 aa)
DHTKD1Dehydrogenase E1 and transketolase domain containing 1. (917 aa)
BCAT2Branched chain amino acid transaminase 2. (391 aa)
HK2Hexokinase 2. (917 aa)
ENO4Enolase 4. (622 aa)
DLSTDihydrolipoamide S-succinyltransferase. (455 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (507 aa)
OGDHOxoglutarate dehydrogenase. (1034 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (344 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (466 aa)
DERADeoxyribose-phosphate aldolase. (320 aa)
SUCLG2Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (431 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (663 aa)
GCDHGlutaryl-CoA dehydrogenase. (438 aa)
MDH1Malate dehydrogenase. (334 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (420 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4. (469 aa)
GNEGlucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase. (752 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (796 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (418 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (532 aa)
BCAT1Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (348 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (476 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (664 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (282 aa)
GCKPhosphotransferase. (465 aa)
BCKDKProtein-serine/threonine kinase. (412 aa)
RPERibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (235 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
TPI1Triosephosphate isomerase. (249 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (467 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (899 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (534 aa)
G3TZZ7_LOXAFPFK domain-containing protein. (149 aa)
MYCBPAPMYCBP associated protein. (929 aa)
ENO3Enolase 3. (434 aa)
HK1Hexokinase 1. (916 aa)
GPTGlutamic--pyruvic transaminase. (456 aa)
G3U8F6_LOXAFGp_dh_C domain-containing protein. (71 aa)
TKTL2Transketolase like 2. (627 aa)
BCKDHA2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (449 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (404 aa)
PGAM4Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (262 aa)
SORDSorbitol dehydrogenase. (367 aa)
PFKLPhosphofructokinase, liver type. (754 aa)
PDHA1E1_dh domain-containing protein. (392 aa)
PDK2Protein-serine/threonine kinase. (362 aa)
DLDDihydrolipoyl dehydrogenase. (509 aa)
GPT2Glutamic--pyruvic transaminase 2. (523 aa)
MPSTSulfurtransferase. (297 aa)
G3UNL7_LOXAFGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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