STRINGSTRING
ESCO2 ESCO2 CENPB CENPB KDM4A KDM4A SUZ12 SUZ12 TNKS1BP1 TNKS1BP1 SNAI1 SNAI1 G3UF27_LOXAF G3UF27_LOXAF MBD3 MBD3 G3UB93_LOXAF G3UB93_LOXAF PSIP1 PSIP1 G3U976_LOXAF G3U976_LOXAF G3U948_LOXAF G3U948_LOXAF UHRF1 UHRF1 RRP1B RRP1B DNMT3A DNMT3A SIRT6 SIRT6 BAZ1B BAZ1B TRIM28 TRIM28 HMGA2 HMGA2 RNF2 RNF2 G3U1J3_LOXAF G3U1J3_LOXAF KDM4C KDM4C G3TZ65_LOXAF G3TZ65_LOXAF HMGA1 HMGA1 IKZF1 IKZF1 DNMT3L DNMT3L KDM4B KDM4B G3TSC5_LOXAF G3TSC5_LOXAF CBX2 CBX2 SALL1 SALL1 EME1 EME1 PCGF2 PCGF2 SIRT2 SIRT2 RING1 RING1 ORC2 ORC2 ATRX ATRX CBX1 CBX1 G3THQ5_LOXAF G3THQ5_LOXAF MECP2 MECP2 G3TEP4_LOXAF G3TEP4_LOXAF MBD2 MBD2 MORC2 MORC2 CENPC CENPC ZNF618 ZNF618 TASOR TASOR BAZ1A BAZ1A SIRT1 SIRT1 BAZ2A BAZ2A CBX8 CBX8 MACROH2A1 MACROH2A1 WDR76 WDR76 HELLS HELLS CBX3 CBX3 LRWD1 LRWD1 MPHOSPH8 MPHOSPH8 CHD5 CHD5 HDAC2 HDAC2 BEND3 BEND3 NCAPD3 NCAPD3 HDAC1 HDAC1 SALL4 SALL4 DNMT1 DNMT1 EZH2 EZH2 CBX5 CBX5 CHRAC1 CHRAC1 UHRF2 UHRF2 RRP8 RRP8 SMARCAD1 SMARCAD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (618 aa)
CENPBCentromere protein B. (379 aa)
KDM4AUncharacterized protein. (1067 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
TNKS1BP1Tankyrase 1 binding protein 1. (1684 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
G3UF27_LOXAFSET domain-containing protein. (338 aa)
MBD3Methyl-CpG binding domain protein 3. (269 aa)
G3UB93_LOXAFRAWUL domain-containing protein. (334 aa)
PSIP1PC4 and SFRS1 interacting protein 1. (531 aa)
G3U976_LOXAFANK_REP_REGION domain-containing protein. (259 aa)
G3U948_LOXAFUncharacterized protein. (76 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (811 aa)
RRP1BRibosomal RNA processing 1B. (664 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
SIRT6Sirtuin 6. (336 aa)
BAZ1BBromo domain-containing protein. (118 aa)
TRIM28Tripartite motif containing 28. (785 aa)
HMGA2Uncharacterized protein. (108 aa)
RNF2RING-type domain-containing protein. (308 aa)
G3U1J3_LOXAFINCENP_ARK-bind domain-containing protein. (267 aa)
KDM4CLysine demethylase 4C. (1054 aa)
G3TZ65_LOXAFINCENP_N domain-containing protein. (491 aa)
HMGA1High mobility group AT-hook 1. (107 aa)
IKZF1IKAROS family zinc finger 1. (489 aa)
DNMT3LPHD-type domain-containing protein. (379 aa)
KDM4BLysine demethylase 4B. (1123 aa)
G3TSC5_LOXAFUncharacterized protein. (179 aa)
CBX2Chromobox 2. (486 aa)
SALL1Spalt like transcription factor 1. (1289 aa)
EME1Essential meiotic structure-specific endonuclease 1. (575 aa)
PCGF2Polycomb group ring finger 2. (343 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (392 aa)
RING1Ring finger protein 1. (406 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
ATRXATRX chromatin remodeler. (2249 aa)
CBX1Chromobox 1. (185 aa)
G3THQ5_LOXAFRING-type domain-containing protein. (330 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (469 aa)
G3TEP4_LOXAFUncharacterized protein. (932 aa)
MBD2Methyl-CpG binding domain protein 2. (295 aa)
MORC2MORC family CW-type zinc finger 2. (1033 aa)
CENPCCentromere protein C. (933 aa)
ZNF618Zinc finger protein 618. (931 aa)
TASORTranscription activation suppressor. (1618 aa)
BAZ1ABromodomain adjacent to zinc finger domain 1A. (1515 aa)
SIRT1Sirtuin 1. (605 aa)
BAZ2ABromodomain adjacent to zinc finger domain 2A. (1878 aa)
CBX8Chromobox 8. (365 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (630 aa)
HELLSHelicase, lymphoid specific. (822 aa)
CBX3Uncharacterized protein. (183 aa)
LRWD1Leucine rich repeats and WD repeat domain containing 1. (649 aa)
MPHOSPH8Chromo domain-containing protein. (362 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1928 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (487 aa)
BEND3BEN domain containing 3. (828 aa)
NCAPD3Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1470 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1628 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
CBX5Chromobox 5. (191 aa)
CHRAC1Chromatin accessibility complex subunit 1. (131 aa)
UHRF2Ubiquitin like with PHD and ring finger domains 2. (803 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (457 aa)
SMARCAD1Uncharacterized protein. (1024 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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