STRINGSTRING
ACTN3 ACTN3 G3U1P0_LOXAF G3U1P0_LOXAF PTH PTH CRY1 CRY1 C1QTNF1 C1QTNF1 LEP LEP G3TS21_LOXAF G3TS21_LOXAF C1QTNF6 C1QTNF6 PDK3 PDK3 BAD BAD BCKDK BCKDK GCK GCK RORC RORC TIGAR TIGAR SLC45A3 SLC45A3 G3TG57_LOXAF G3TG57_LOXAF ZMPSTE24 ZMPSTE24 ERFE ERFE PDK4 PDK4 GPLD1 GPLD1 C1QTNF12 C1QTNF12 DDB1 DDB1 STK11 STK11 IGFBP4 IGFBP4 PTPN2 PTPN2 COX11 COX11 EP300 EP300 TFF3 TFF3 SLC35B4 SLC35B4 PPARA PPARA GNMT GNMT IGFBP3 IGFBP3 SIRT7 SIRT7 RORA RORA RANBP2 RANBP2 SIK1 SIK1 LCMT1 LCMT1 SORBS1 SORBS1 ACADM ACADM G3SS82_LOXAF G3SS82_LOXAF MST1 MST1 LEPR LEPR ADIPOQ ADIPOQ DGKQ DGKQ PGP PGP PDK1 PDK1 KAT2B KAT2B GCKR GCKR TP53 TP53 USP7 USP7 G3T0P7_LOXAF G3T0P7_LOXAF KAT2A KAT2A MLYCD MLYCD OGT OGT FOXK2 FOXK2 NCOA2 NCOA2 SIRT1 SIRT1 G3ULT4_LOXAF G3ULT4_LOXAF G3ULQ3_LOXAF G3ULQ3_LOXAF G3UK14_LOXAF G3UK14_LOXAF PDK2 PDK2 G3UJ00_LOXAF G3UJ00_LOXAF G3UI57_LOXAF G3UI57_LOXAF G3UHY3_LOXAF G3UHY3_LOXAF G3UHE5_LOXAF G3UHE5_LOXAF G3UHA8_LOXAF G3UHA8_LOXAF INSR INSR EPM2AIP1 EPM2AIP1 FOXK1 FOXK1 C1QTNF3 C1QTNF3 G3UDE4_LOXAF G3UDE4_LOXAF CLK2 CLK2 SOGA1 SOGA1 FOXA2 FOXA2 G3UAZ0_LOXAF G3UAZ0_LOXAF FAM3C FAM3C DUSP12 DUSP12 SESN2 SESN2 ZNF692 ZNF692 G3U6U6_LOXAF G3U6U6_LOXAF G3U6D1_LOXAF G3U6D1_LOXAF SIRT6 SIRT6 SERPINA12 SERPINA12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTN3Actinin alpha 3 (gene/pseudogene). (902 aa)
G3U1P0_LOXAFHomeobox domain-containing protein. (160 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
CRY1Cryptochrome circadian regulator 1. (606 aa)
C1QTNF1C1q and TNF related 1. (290 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
G3TS21_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (363 aa)
C1QTNF6C1q and TNF related 6. (271 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
BADBCL2 associated agonist of cell death. (206 aa)
BCKDKProtein-serine/threonine kinase. (412 aa)
GCKPhosphotransferase. (465 aa)
RORCRAR related orphan receptor C. (517 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
SLC45A3Solute carrier family 45 member 3. (552 aa)
G3TG57_LOXAFIlGF domain-containing protein. (118 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
ERFEErythroferrone. (331 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (840 aa)
C1QTNF12C1q and TNF related 12. (308 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
STK11Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
IGFBP4Insulin like growth factor binding protein 4. (260 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (409 aa)
COX11Cytochrome c oxidase copper chaperone COX11. (275 aa)
EP300E1A binding protein p300. (2420 aa)
TFF3Trefoil factor 3. (81 aa)
SLC35B4Solute carrier family 35 member B4. (331 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
GNMTGlycine N-methyltransferase. (296 aa)
IGFBP3Insulin like growth factor binding protein 3. (296 aa)
SIRT7Sirtuin 7. (329 aa)
RORARAR related orphan receptor A. (467 aa)
RANBP2RAN binding protein 2. (3072 aa)
SIK1Uncharacterized protein. (795 aa)
LCMT1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (334 aa)
SORBS1Sorbin and SH3 domain containing 1. (1291 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (445 aa)
G3SS82_LOXAFUncharacterized protein. (90 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (718 aa)
LEPRLeptin receptor. (835 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (245 aa)
DGKQDiacylglycerol kinase. (850 aa)
PGPPhosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (321 aa)
PDK1Protein-serine/threonine kinase. (389 aa)
KAT2BLysine acetyltransferase 2B. (755 aa)
GCKRGlucokinase regulator. (621 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1078 aa)
G3T0P7_LOXAFUncharacterized protein. (58 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (802 aa)
MLYCDMalonyl-CoA decarboxylase. (497 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
FOXK2Forkhead box K2. (520 aa)
NCOA2Nuclear receptor coactivator. (1461 aa)
SIRT1Sirtuin 1. (605 aa)
G3ULT4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
G3ULQ3_LOXAFTyrosine-protein phosphatase non-receptor type. (369 aa)
G3UK14_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (365 aa)
PDK2Protein-serine/threonine kinase. (362 aa)
G3UJ00_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
G3UI57_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa)
G3UHY3_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (288 aa)
G3UHE5_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
G3UHA8_LOXAFProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (430 aa)
INSRTyrosine-protein kinase receptor. (1366 aa)
EPM2AIP1EPM2A interacting protein 1. (606 aa)
FOXK1Forkhead box K1. (546 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
G3UDE4_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa)
CLK2CDC like kinase 2; Belongs to the protein kinase superfamily. (500 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1472 aa)
FOXA2Forkhead box A2. (446 aa)
G3UAZ0_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
DUSP12Dual specificity phosphatase 12. (338 aa)
SESN2Sestrin 2. (485 aa)
ZNF692Uncharacterized protein. (137 aa)
G3U6U6_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
G3U6D1_LOXAFCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa)
SIRT6Sirtuin 6. (336 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (413 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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