(18 nodes) Intercalated disc network (Loxodonta africana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	AKAP6	A-kinase anchoring protein 6. (2304 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (825 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
	RANGRF	RAN guanine nucleotide release factor. (186 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	CTNNB1	Catenin beta 1. (780 aa)
	VCL	Vinculin. (1066 aa)
	PKP2	Plakophilin 2. (818 aa)
	PGM5	Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (484 aa)
	SCN1B	Sodium voltage-gated channel beta subunit 1. (205 aa)
	SCN4B	Sodium voltage-gated channel beta subunit 4. (228 aa)
	G3UMU2_LOXAF	Uncharacterized protein. (43 aa)
	CXADR	Uncharacterized protein. (365 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	JUP	Junction plakoglobin. (741 aa)
	NRAP	Nebulin related anchoring protein. (1733 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	GJA1	ENSLAFP00000015325	ENSLAFP00000009479	Catenin beta 1.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.604
CTNNB1	ITGB1	ENSLAFP00000015325	ENSLAFP00000015222	Catenin beta 1.	Integrin beta; Belongs to the integrin beta chain family.	0.511
CTNNB1	JUP	ENSLAFP00000015325	ENSLAFP00000002387	Catenin beta 1.	Junction plakoglobin.	0.967
CTNNB1	PIK3CA	ENSLAFP00000015325	ENSLAFP00000002561	Catenin beta 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.526
CTNNB1	PKP2	ENSLAFP00000015325	ENSLAFP00000019552	Catenin beta 1.	Plakophilin 2.	0.571
CTNNB1	VCL	ENSLAFP00000015325	ENSLAFP00000017626	Catenin beta 1.	Vinculin.	0.865
GJA1	CTNNB1	ENSLAFP00000009479	ENSLAFP00000015325	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Catenin beta 1.	0.604
GJA1	GJA5	ENSLAFP00000009479	ENSLAFP00000019383	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.827
GJA1	JUP	ENSLAFP00000009479	ENSLAFP00000002387	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Junction plakoglobin.	0.492
GJA1	PKP2	ENSLAFP00000009479	ENSLAFP00000019552	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Plakophilin 2.	0.674
GJA1	VCL	ENSLAFP00000009479	ENSLAFP00000017626	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Vinculin.	0.446
GJA5	GJA1	ENSLAFP00000019383	ENSLAFP00000009479	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.827
ITGB1	CTNNB1	ENSLAFP00000015222	ENSLAFP00000015325	Integrin beta; Belongs to the integrin beta chain family.	Catenin beta 1.	0.511
ITGB1	PIK3CA	ENSLAFP00000015222	ENSLAFP00000002561	Integrin beta; Belongs to the integrin beta chain family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.943
ITGB1	VCL	ENSLAFP00000015222	ENSLAFP00000017626	Integrin beta; Belongs to the integrin beta chain family.	Vinculin.	0.833
JUP	CTNNB1	ENSLAFP00000002387	ENSLAFP00000015325	Junction plakoglobin.	Catenin beta 1.	0.967
JUP	GJA1	ENSLAFP00000002387	ENSLAFP00000009479	Junction plakoglobin.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.492
JUP	PKP2	ENSLAFP00000002387	ENSLAFP00000019552	Junction plakoglobin.	Plakophilin 2.	0.908
JUP	VCL	ENSLAFP00000002387	ENSLAFP00000017626	Junction plakoglobin.	Vinculin.	0.753
PIK3CA	CTNNB1	ENSLAFP00000002561	ENSLAFP00000015325	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Catenin beta 1.	0.526

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