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| | PPARGC1A | PPARG coactivator 1 alpha. (796 aa) |
| | MTFR1 | Mitochondrial fission regulator 1. (328 aa) |
| | IREB2 | Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (962 aa) |
| | PHKG1 | Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (386 aa) |
| | DLST | Dihydrolipoamide S-succinyltransferase. (455 aa) |
| | NDUFB9 | NADH:ubiquinone oxidoreductase subunit B9; Belongs to the complex I LYR family. (179 aa) |
| | NDUFA8 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (172 aa) |
| | DHTKD1 | Dehydrogenase E1 and transketolase domain containing 1. (917 aa) |
| | COX6A2 | Cytochrome c oxidase subunit 6A, mitochondrial. (97 aa) |
| | CUNH1orf198 | DUF4706 domain-containing protein. (229 aa) |
| | COX8A | Cytochrome c oxidase subunit 8A. (69 aa) |
| | BLOC1S1 | Uncharacterized protein. (125 aa) |
| | POLG2 | DNA polymerase gamma 2, accessory subunit. (485 aa) |
| | UQCR10 | Ubiquinol-cytochrome c reductase, complex III subunit X. (64 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa) |
| | UQCRQ | Ubiquinol-cytochrome c reductase complex III subunit VII. (82 aa) |
| | NDUFV2 | NADH:ubiquinone oxidoreductase core subunit V2. (251 aa) |
| | PHKG2 | Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa) |
| | IDH2 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (415 aa) |
| | DLAT | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa) |
| | EPM2A | EPM2A glucan phosphatase, laforin. (325 aa) |
| | FXN | Frataxin. (208 aa) |
| | STK40 | Serine/threonine kinase 40. (441 aa) |
| | UQCRC1 | Ubiquinol-cytochrome c reductase core protein 1. (480 aa) |
| | COX6C | Cytochrome c oxidase subunit 6C. (75 aa) |
| | PHKA2 | Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1236 aa) |
| | COX5B | Cytochrome c oxidase subunit 5B. (129 aa) |
| | COX7B2 | Cytochrome c oxidase subunit 7B2. (79 aa) |
| | ADGRF5 | Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1271 aa) |
| | PUM2 | Pumilio RNA binding family member 2. (1070 aa) |
| | PPP1R3A | Protein phosphatase 1 regulatory subunit 3A. (1041 aa) |
| | PPP1R1A | Protein phosphatase 1 regulatory inhibitor subunit 1A. (149 aa) |
| | G3T2S2_LOXAF | Uncharacterized protein. (91 aa) |
| | OGDHL | Oxoglutarate dehydrogenase like. (1011 aa) |
| | PDHA2 | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (392 aa) |
| | ETFRF1 | Electron transfer flavoprotein regulatory factor 1; Belongs to the complex I LYR family. (86 aa) |
| | SDHC | Succinate dehydrogenase complex subunit C. (169 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa) |
| | MRPS36 | Mitochondrial ribosomal protein S36. (102 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | LOC100676911 | Cytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family. (91 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa) |
| | GBE1 | 1,4-alpha-glucan branching enzyme 1. (694 aa) |
| | GYS1 | Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa) |
| | PHKA1 | Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1247 aa) |
| | IDH3G | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (393 aa) |
| | STBD1 | Starch binding domain 1. (351 aa) |
| | GYG1 | Glycogenin 1. (348 aa) |
| | NDUFAF1 | NADH:ubiquinone oxidoreductase complex assembly factor 1. (327 aa) |
| | PHKB | Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1068 aa) |
| | NDUFS2 | NADH:ubiquinone oxidoreductase core subunit S2; Belongs to the complex I 49 kDa subunit family. (463 aa) |
| | COX6A1 | Cytochrome c oxidase subunit 6A, mitochondrial. (110 aa) |
| | NDUFS8 | NADH:ubiquinone oxidoreductase core subunit S8. (210 aa) |
| | COX5A | Cytochrome c oxidase subunit 5A. (117 aa) |
| | IMMP2L | Uncharacterized protein. (56 aa) |
| | ACO2 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (779 aa) |
| | AFG1L | AFG1 like ATPase. (445 aa) |
| | CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa) |
| | LOC100666038 | Uncharacterized protein. (55 aa) |
| | FH | Fumarate hydratase. (508 aa) |
| | NDUFS6 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (124 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa) |
| | NDUFB6 | NADH:ubiquinone oxidoreductase subunit B6. (127 aa) |
| | MDH2 | Malate dehydrogenase. (338 aa) |
| | PGM2 | Phosphoglucomutase 2. (616 aa) |
| | MYBBP1A | MYB binding protein 1a. (1315 aa) |
| | DNAJC15 | DnaJ heat shock protein family (Hsp40) member C15. (146 aa) |
| | SDHAF2 | Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (142 aa) |
| | LEPR | Leptin receptor. (835 aa) |
| | TAZ | Tafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (293 aa) |
| | IDH3A | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (366 aa) |
| | ACADM | Acyl-CoA dehydrogenase medium chain. (445 aa) |
| | PDHB | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa) |
| | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (156 aa) |
| | SDHAF4 | Succinate dehydrogenase complex assembly factor 4. (104 aa) |
| | UQCRB | Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family. (106 aa) |
| | COX7A2 | Cytochrome c oxidase subunit 7A2. (109 aa) |
| | MTFR1L | Mitochondrial fission regulator 1 like. (289 aa) |
| | COQ9 | Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. (319 aa) |
| | NDUFV3 | NADH:ubiquinone oxidoreductase subunit V3. (460 aa) |
| | IDH3B | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa) |
| | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (120 aa) |
| | GYS2 | Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (702 aa) |
| | COX7A1 | Cytochrome c oxidase subunit 7A1. (80 aa) |
| | AGL | Amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase. (1554 aa) |
| | GYG2 | Glycogenin 2. (425 aa) |
| | UGP2 | UTP--glucose-1-phosphate uridylyltransferase. (508 aa) |
| | ATP5F1E | ATP synthase F1 subunit epsilon. (51 aa) |
| | ATP5PD | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (161 aa) |
| | COQ10B | Coenzyme Q10B. (238 aa) |
| | CYTB | Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (378 aa) |
| | ND6 | NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (175 aa) |
| | ND5 | NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (606 aa) |
| | MT-ND4 | NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (459 aa) |
| | ND4L | NADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (98 aa) |
| | ND3 | NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (117 aa) |
| | COX3 | Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (261 aa) |
| | MT-ATP6 | ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (222 aa) |
| | COX1 | Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (515 aa) |
| | ND2 | NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (347 aa) |
| | ND1 | NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (318 aa) |
| | SLC25A18 | Solute carrier family 25 member 18; Belongs to the mitochondrial carrier (TC 2.A.29) family. (314 aa) |
| | ETFA | Electron transfer flavoprotein subunit alpha. (334 aa) |
| | RB1CC1 | ATG11 domain-containing protein. (1595 aa) |
| | G3ULT4_LOXAF | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa) |
| | MRAP2 | Melanocortin 2 receptor accessory protein 2. (208 aa) |
| | PPP1R3B | Protein phosphatase 1 regulatory subunit. (284 aa) |
| | G3UK14_LOXAF | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (365 aa) |
| | G3UJP2_LOXAF | Uncharacterized protein. (76 aa) |
| | G3UJ00_LOXAF | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa) |
| | G3UI57_LOXAF | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (360 aa) |
| | G3UHY3_LOXAF | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (288 aa) |
| | G3UHE5_LOXAF | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa) |
| | PDHA1 | E1_dh domain-containing protein. (392 aa) |
| | G3UH69_LOXAF | zf-CHCC domain-containing protein. (119 aa) |
| | G3UGU2_LOXAF | ATG11 domain-containing protein. (216 aa) |
| | PPP1R3E | Protein phosphatase 1 regulatory subunit 3E. (184 aa) |
| | CHCHD5 | Coiled-coil-helix-coiled-coil-helix domain containing 5. (110 aa) |
| | EPM2AIP1 | EPM2A interacting protein 1. (606 aa) |
| | C17orf80 | Chromosome 17 open reading frame 80. (589 aa) |
| | G3UDE4_LOXAF | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (362 aa) |
| | MTFR2 | Mitochondrial fission regulator 2. (352 aa) |
| | COX6B2 | Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (88 aa) |
| | PYGB | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (714 aa) |
| | G3UAZ0_LOXAF | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa) |
| | ATP5ME | ATP synthase membrane subunit e. (63 aa) |
| | SLC25A22 | Solute carrier family 25 member 22; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa) |
| | NDUFS7 | NADH:ubiquinone oxidoreductase core subunit S7; Belongs to the complex I 20 kDa subunit family. (138 aa) |
| | PPP1R3C | Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1. (611 aa) |
| | G3U6U6_LOXAF | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa) |
| | SLC37A4 | Solute carrier family 37 member 4. (430 aa) |
| | G3U6D1_LOXAF | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (364 aa) |
| | G3U6C6_LOXAF | Uncharacterized protein. (98 aa) |
| | MT3 | Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa) |
| | G3U5G5_LOXAF | Uncharacterized protein. (70 aa) |
| | SIRT3 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (257 aa) |
| | NDUFA5 | NADH:ubiquinone oxidoreductase subunit A5. (95 aa) |
| | COQ10A | Coenzyme Q10A. (252 aa) |
| | NDUFA12 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (149 aa) |
| | PPP1R3G | Protein phosphatase 1 regulatory subunit 3G. (282 aa) |
| | UCN | Urocortin. (117 aa) |
| | CYC1 | Cytochrome c1. (324 aa) |
| | COX6B1 | Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (88 aa) |
| | ACO1 | Aconitase 1; Belongs to the aconitase/IPM isomerase family. (899 aa) |
| | ATP5F1B | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa) |
| | G3TSM0_LOXAF | Uncharacterized protein. (98 aa) |
| | STOML2 | Stomatin like 2. (357 aa) |
| | G3TS21_LOXAF | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (363 aa) |
| | SUCLA2 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (467 aa) |
| | NDUFV1 | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (465 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | UQCRFS1 | Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (274 aa) |
| | COX7A2L | Cytochrome c oxidase subunit 7A2 like. (113 aa) |
| | DGUOK | Deoxyguanosine kinase. (228 aa) |
| | COX7B | Cytochrome c oxidase subunit 7B. (80 aa) |
| | ETFB | Electron transfer flavoprotein subunit beta. (256 aa) |
| | PRLH | Prolactin releasing hormone. (98 aa) |
| | TEFM | Transcription elongation factor, mitochondrial. (359 aa) |
| | B3GNTL1 | Uncharacterized protein. (118 aa) |
| | ATP5F1D | ATP synthase F1 subunit delta. (122 aa) |
| | C2orf69 | Chromosome 2 open reading frame 69. (386 aa) |
| | SLC25A12 | Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (673 aa) |
| | SDHB | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (282 aa) |
| | SLC25A13 | Solute carrier family 25 member 13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (674 aa) |
| | NDUFA7 | Uncharacterized protein. (114 aa) |
| | SDHA | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (664 aa) |
| | NDUFS3 | NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (262 aa) |
| | COX7C | Cytochrome c oxidase subunit 7C. (63 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (871 aa) |
| | PYGM | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa) |
| | PCDH12 | Protocadherin 12. (1164 aa) |
| | IL6ST | Interleukin 6 signal transducer. (921 aa) |
| | NR4A3 | Nuclear receptor subfamily 4 group A member 3. (626 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (270 aa) |
| | IDH1 | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (420 aa) |
| | NDUFB8 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (186 aa) |
| | MDH1 | Malate dehydrogenase. (334 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (490 aa) |
| | PPP1R3D | Protein phosphatase 1 regulatory subunit. (285 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa) |
| | AIFM2 | Apoptosis inducing factor mitochondria associated 2. (373 aa) |
| | MDH1B | Malate dehydrogenase 1B. (463 aa) |
| | GSK3A | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (482 aa) |
| | PPP1R32 | Protein phosphatase 1 regulatory subunit 32. (425 aa) |
| | PYGL | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (846 aa) |
| | SUCLG2 | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (431 aa) |
| | NDUFS4 | Uncharacterized protein. (83 aa) |
| | CS | Citrate synthase; Belongs to the citrate synthase family. (466 aa) |
| | ATP5F1A | ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (705 aa) |
| | SUCLG1 | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (344 aa) |
| | ATP5F1C | ATP synthase subunit gamma. (297 aa) |
| | ETFDH | Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (621 aa) |
| | COX4I1 | Cytochrome c oxidase subunit 4I1. (169 aa) |
| | NDUFS1 | NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (727 aa) |
| | OGDH | Oxoglutarate dehydrogenase. (1034 aa) |
| | PINK1 | PTEN induced kinase 1. (582 aa) |
| | UQCC3 | Ubiquinol-cytochrome c reductase complex assembly factor 3. (90 aa) |
| | ATP5PO | Uncharacterized protein. (213 aa) |
