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SC5D SC5D PRKAA2 PRKAA2 NSDHL NSDHL CYB5R3 CYB5R3 PRKAA1 PRKAA1 HMGCS1 HMGCS1 NPC1L1 NPC1L1 SREBF1 SREBF1 HSD17B7 HSD17B7 INSIG1 INSIG1 LOC100673111 LOC100673111 MVK MVK FDFT1 FDFT1 HMGCR HMGCR ERG28 ERG28 DHCR24 DHCR24 G3SW83_LOXAF G3SW83_LOXAF DHCR7 DHCR7 CFTR CFTR IDI2 IDI2 LOC100673402 LOC100673402 MVD MVD CYB5R2 CYB5R2 SQLE SQLE IDI1 IDI1 CYB5R1 CYB5R1 LSS LSS INSIG2 INSIG2 HSD17B7-2 HSD17B7-2 TM7SF2 TM7SF2 CYP51A1 CYP51A1 CH25H CH25H PMVK PMVK APOA5 APOA5 LBR LBR G6PD G6PD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (361 aa)
CYB5R3NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (252 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1343 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1087 aa)
HSD17B7Hydroxysteroid 17-beta dehydrogenase 7. (335 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (263 aa)
LOC100673111Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (295 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (409 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (419 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (890 aa)
ERG28Ergosterol biosynthesis 28 homolog. (140 aa)
DHCR2424-dehydrocholesterol reductase. (515 aa)
G3SW83_LOXAFEXPERA domain-containing protein. (232 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1479 aa)
IDI2Isopentenyl-diphosphate delta isomerase 2. (227 aa)
LOC100673402Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (293 aa)
MVDDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (398 aa)
CYB5R2NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (304 aa)
SQLESqualene epoxidase. (569 aa)
IDI1Isopentenyl-diphosphate delta isomerase 1. (227 aa)
CYB5R1NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (734 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
HSD17B7-2Uncharacterized protein. (302 aa)
TM7SF2Transmembrane 7 superfamily member 2. (420 aa)
CYP51A1Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
CH25HCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (275 aa)
PMVKPhosphomevalonate kinase. (164 aa)
APOA5Apolipoprotein A5. (371 aa)
LBRLamin B receptor. (619 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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