STRINGSTRING
IMMP1L IMMP1L IL1R2 IL1R2 CORIN CORIN IFT172 IFT172 FURIN FURIN CTSH CTSH ADAM10 ADAM10 LONP2 LONP2 APAF1 APAF1 G3TEN6_LOXAF G3TEN6_LOXAF METAP1 METAP1 PCSK5 PCSK5 GLG1 GLG1 ZMPSTE24 ZMPSTE24 CASP9 CASP9 SPCS1 SPCS1 AFG3L2 AFG3L2 PLAU PLAU CPM CPM SEC11A SEC11A ECE2 ECE2 PITRM1 PITRM1 FGB FGB FGG FGG CIDEC CIDEC KLKB1 KLKB1 F11 F11 PCSK7 PCSK7 BACE1 BACE1 PMPCA PMPCA CASP8 CASP8 BMP1 BMP1 DDI2 DDI2 YME1L1 YME1L1 TMEM208 TMEM208 HJV HJV G3TNV6_LOXAF G3TNV6_LOXAF P2RX7 P2RX7 BAD BAD LOC100660900 LOC100660900 CNTN2 CNTN2 SPRTN SPRTN COMP COMP FKRP FKRP STOML2 STOML2 PSENEN PSENEN PIDD1 PIDD1 MIPEP MIPEP CPN1 CPN1 ADAM19 ADAM19 DISP1 DISP1 SPG7 SPG7 IHH IHH DYNC2H1 DYNC2H1 PISD PISD PSEN2 PSEN2 APOH APOH RIPK2 RIPK2 G3U3C4_LOXAF G3U3C4_LOXAF CIDEB CIDEB PTCH1 PTCH1 PAWR PAWR XPNPEP3 XPNPEP3 PRSS12 PRSS12 PARP1 PARP1 TLL2 TLL2 SEC11C SEC11C CD5L CD5L MYRF MYRF PCSK1N PCSK1N G3U5N1_LOXAF G3U5N1_LOXAF CASP6 CASP6 METAP2 METAP2 PSEN1 PSEN1 CPLANE2 CPLANE2 KEL KEL PMPCB PMPCB TMPRSS2 TMPRSS2 LGMN LGMN ASPRV1 ASPRV1 BACE2 BACE2 TYSND1 TYSND1 F12 F12 CPXM2 CPXM2 PCSK2 PCSK2 G3ULI4_LOXAF G3ULI4_LOXAF CPZ CPZ SHH SHH OGT OGT MMEL1 MMEL1 GLI3 GLI3 MEP1A MEP1A ADAM17 ADAM17 FXN FXN OMA1 OMA1 MMP16 MMP16 SDE2 SDE2 TLL1 TLL1 APH1B APH1B BAK1 BAK1 MYRFL MYRFL PCSK9 PCSK9 ECEL1 ECEL1 RCE1 RCE1 TBC1D10A TBC1D10A SPPL3 SPPL3 G3STW9_LOXAF G3STW9_LOXAF APH1A APH1A DHCR24 DHCR24 TMPRSS4 TMPRSS4 CASP2 CASP2 G3SVL7_LOXAF G3SVL7_LOXAF PCSK1 PCSK1 SCG5 SCG5 CPE CPE ECE1 ECE1 PYCARD PYCARD F9 F9 SPCS2 SPCS2 MBTPS1 MBTPS1 IMMP2L IMMP2L ADAMTS2 ADAMTS2 ACE ACE CPXM1 CPXM1 HM13 HM13 DHH DHH CASP7 CASP7 PLAT PLAT SPCS3 SPCS3 G3T5G6_LOXAF G3T5G6_LOXAF PHEX PHEX NLRP6 NLRP6 NCSTN NCSTN TMPRSS12 TMPRSS12 ADAMTS3 ADAMTS3 F3 F3 MMP14 MMP14 G3SQ64_LOXAF G3SQ64_LOXAF CPD CPD SPON1 SPON1 ATP23 ATP23 CYFIP2 CYFIP2 PCSK6 PCSK6 CLN5 CLN5 ASPH ASPH
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IMMP1LMitochondrial inner membrane protease subunit. (166 aa)
IL1R2Interleukin 1 receptor type 2. (408 aa)
CORINUncharacterized protein. (781 aa)
IFT172Intraflagellar transport 172. (1749 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (792 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (335 aa)
ADAM10ADAM metallopeptidase domain 10. (639 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (853 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1246 aa)
G3TEN6_LOXAFIg-like domain-containing protein. (307 aa)
METAP1Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (386 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5. (1678 aa)
GLG1Golgi glycoprotein 1. (1169 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (450 aa)
SPCS1Signal peptidase complex subunit 1. (102 aa)
AFG3L2AFG3 like matrix AAA peptidase subunit 2. (798 aa)
PLAUPlasminogen activator, urokinase. (406 aa)
CPMCarboxypeptidase M. (443 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (180 aa)
ECE2EEF1AKMT4-ECE2 readthrough. (911 aa)
PITRM1Pitrilysin metallopeptidase 1. (1037 aa)
FGBFibrinogen beta chain. (483 aa)
FGGFibrinogen gamma chain. (444 aa)
CIDECCell death inducing DFFA like effector c. (238 aa)
KLKB1Kallikrein B1; Belongs to the peptidase S1 family. (640 aa)
F11Coagulation factor XI; Belongs to the peptidase S1 family. (631 aa)
PCSK7Proprotein convertase subtilisin/kexin type 7. (775 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (502 aa)
PMPCAPeptidase, mitochondrial processing alpha subunit; Belongs to the peptidase M16 family. (506 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (478 aa)
BMP1Metalloendopeptidase. (993 aa)
DDI2DNA damage inducible 1 homolog 2. (399 aa)
YME1L1YME1 like 1 ATPase. (712 aa)
TMEM208Transmembrane protein 208. (173 aa)
HJVHemojuvelin BMP co-receptor. (422 aa)
G3TNV6_LOXAFUncharacterized protein. (354 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (599 aa)
BADBCL2 associated agonist of cell death. (206 aa)
LOC100660900AAA domain-containing protein. (787 aa)
CNTN2Contactin 2. (1043 aa)
SPRTNSprT-like N-terminal domain. (492 aa)
COMPCartilage oligomeric matrix protein. (638 aa)
FKRPFukutin related protein. (478 aa)
STOML2Stomatin like 2. (357 aa)
PSENENUncharacterized protein. (101 aa)
PIDD1P53-induced death domain protein 1. (917 aa)
MIPEPMitochondrial intermediate peptidase. (719 aa)
CPN1Carboxypeptidase N subunit 1. (461 aa)
ADAM19EGF-like domain-containing protein. (319 aa)
DISP1Dispatched RND transporter family member 1. (1534 aa)
SPG7SPG7 matrix AAA peptidase subunit, paraplegin. (777 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4122 aa)
PISDPhosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (359 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (451 aa)
APOHApolipoprotein H. (346 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
G3U3C4_LOXAFUncharacterized protein. (157 aa)
CIDEBCell death inducing DFFA like effector b. (219 aa)
PTCH1Patched 1. (1438 aa)
PAWRUncharacterized protein. (51 aa)
XPNPEP3X-prolyl aminopeptidase 3. (332 aa)
PRSS12Serine protease 12; Belongs to the peptidase S1 family. (769 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (974 aa)
TLL2Metalloendopeptidase. (1022 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (192 aa)
CD5LCD5 molecule like. (354 aa)
MYRFMyelin regulatory factor. (1086 aa)
PCSK1NProprotein convertase subtilisin/kexin type 1 inhibitor. (257 aa)
G3U5N1_LOXAFUncharacterized protein; Belongs to the peptidase C14A family. (471 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (276 aa)
METAP2Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (481 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (440 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
KELKell metallo-endopeptidase (Kell blood group). (707 aa)
PMPCBPeptidase, mitochondrial processing beta subunit. (490 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (490 aa)
LGMNLegumain. (434 aa)
ASPRV1Aspartic peptidase retroviral like 1. (332 aa)
BACE2Beta-secretase 2; Belongs to the peptidase A1 family. (388 aa)
TYSND1Trypsin domain containing 1. (455 aa)
F12Coagulation factor XII; Belongs to the peptidase S1 family. (610 aa)
CPXM2Carboxypeptidase X, M14 family member 2. (620 aa)
PCSK2Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. (638 aa)
G3ULI4_LOXAFUncharacterized protein; Belongs to the peptidase C14A family. (223 aa)
CPZPeptidase_M14 domain-containing protein. (332 aa)
SHHSonic hedgehog signaling molecule. (337 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
MMEL1Membrane metalloendopeptidase like 1. (776 aa)
GLI3GLI family zinc finger 3. (1586 aa)
MEP1AMeprin A subunit. (763 aa)
ADAM17ADAM metallopeptidase domain 17. (845 aa)
FXNFrataxin. (208 aa)
OMA1OMA1 zinc metallopeptidase. (525 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
SDE2SDE2 telomere maintenance homolog. (454 aa)
TLL1Metalloendopeptidase. (1012 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (223 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MYRFLMyelin regulatory factor like. (867 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (660 aa)
ECEL1Endothelin converting enzyme like 1. (775 aa)
RCE1Ras converting CAAX endopeptidase 1. (276 aa)
TBC1D10ARab-GAP TBC domain-containing protein. (431 aa)
SPPL3Signal peptide peptidase like 3. (384 aa)
G3STW9_LOXAFUncharacterized protein. (158 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
DHCR2424-dehydrocholesterol reductase. (515 aa)
TMPRSS4Transmembrane serine protease 4; Belongs to the peptidase S1 family. (433 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
G3SVL7_LOXAFTantalus domain-containing protein. (449 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (753 aa)
SCG5Secretogranin V. (212 aa)
CPECarboxypeptidase E. (476 aa)
ECE1Endothelin converting enzyme 1. (773 aa)
PYCARDPYD and CARD domain containing. (199 aa)
F9Coagulation factor IX. (462 aa)
SPCS2Signal peptidase complex subunit 2. (226 aa)
MBTPS1Membrane bound transcription factor peptidase, site 1. (1057 aa)
IMMP2LUncharacterized protein. (56 aa)
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2. (1034 aa)
ACEAngiotensin-converting enzyme. (1313 aa)
CPXM1Carboxypeptidase X, M14 family member 1. (727 aa)
HM13Histocompatibility minor 13. (393 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (265 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
SPCS3Signal peptidase complex subunit 3. (180 aa)
G3T5G6_LOXAFRhomboid domain-containing protein. (374 aa)
PHEXPhosphate regulating endopeptidase homolog X-linked. (748 aa)
NLRP6Uncharacterized protein. (732 aa)
NCSTNNicastrin. (451 aa)
TMPRSS12Transmembrane serine protease 12; Belongs to the peptidase S1 family. (286 aa)
ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3. (984 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (290 aa)
MMP14Matrix metallopeptidase 14. (583 aa)
G3SQ64_LOXAFUncharacterized protein. (193 aa)
CPDCarboxypeptidase D. (1373 aa)
SPON1Spondin 1. (727 aa)
ATP23Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (185 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1251 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (829 aa)
CLN5Uncharacterized protein. (343 aa)
ASPHAspartate beta-hydroxylase. (691 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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