STRINGSTRING
AMOT AMOT SPRY2 SPRY2 IL17F IL17F TGFB2 TGFB2 SLC12A2 SLC12A2 THBS1 THBS1 PML PML SEMA4A SEMA4A FOXJ2 FOXJ2 RGCC RGCC GTF2I GTF2I CCN6 CCN6 SEMA6A SEMA6A HGS HGS CREB3L1 CREB3L1 HHEX HHEX ATF2 ATF2 DCN DCN ANGPT4 ANGPT4 EPHA2 EPHA2 CXCL10 CXCL10 DAB2IP DAB2IP CD160 CD160 THBS4 THBS4 SULF1 SULF1 TBC1D31 TBC1D31 ISM1 ISM1 GADD45A GADD45A SEMA3E SEMA3E EPN2 EPN2 CLDN5 CLDN5 TNMD TNMD SERPINE1 SERPINE1 ADGRB3 ADGRB3 ANGPT2 ANGPT2 ALOX5 ALOX5 VASH1 VASH1 ATP2B4 ATP2B4 KRIT1 KRIT1 FASLG FASLG G3TAN3_LOXAF G3TAN3_LOXAF STAB1 STAB1 SPRED1 SPRED1 SERPINF1 SERPINF1 ROCK1 ROCK1 ADAMTS1 ADAMTS1 PIK3CB PIK3CB MECP2 MECP2 SYNJ2BP-COX16 SYNJ2BP-COX16 SARS1 SARS1 SPARC SPARC CTNNB1 CTNNB1 CNMD CNMD G3TLN2_LOXAF G3TLN2_LOXAF TIE1 TIE1 G5E792_LOXAF G5E792_LOXAF HOXA5 HOXA5 TEK TEK E2F2 E2F2 STAT1 STAT1 APOH APOH NAXE NAXE EPN1 EPN1 PDE3B PDE3B ABCC8 ABCC8 ROCK2 ROCK2 G3U8D7_LOXAF G3U8D7_LOXAF THBS2 THBS2 NF1 NF1 EFNA3 EFNA3 FOXO4 FOXO4 EMILIN1 EMILIN1 MINAR1 MINAR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AMOTAngiomotin. (1119 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
IL17FUncharacterized protein. (160 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
SLC12A2Solute carrier family 12 member 2. (1202 aa)
THBS1Thrombospondin 1. (1169 aa)
PMLPromyelocytic leukemia. (861 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (760 aa)
FOXJ2Forkhead box J2. (571 aa)
RGCCRegulator of cell cycle. (137 aa)
GTF2IGeneral transcription factor IIi. (1001 aa)
CCN6Cellular communication network factor 6. (238 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (773 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
HHEXHematopoietically expressed homeobox. (152 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (487 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
ANGPT4Angiopoietin 4. (502 aa)
EPHA2EPH receptor A2. (977 aa)
CXCL10C-X-C motif chemokine. (98 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
CD160CD160 molecule. (187 aa)
THBS4Thrombospondin 4. (964 aa)
SULF1Sulfatase 1. (857 aa)
TBC1D31TBC1 domain family member 31. (995 aa)
ISM1Isthmin 1. (457 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (146 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (773 aa)
EPN2Epsin 2. (582 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
TNMDTenomodulin. (317 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (400 aa)
ADGRB3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1270 aa)
ANGPT2Angiopoietin 2. (495 aa)
ALOX5Arachidonate 5-lipoxygenase. (624 aa)
VASH1Vasohibin 1. (264 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1208 aa)
KRIT1Uncharacterized protein. (739 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (277 aa)
G3TAN3_LOXAFUncharacterized protein. (911 aa)
STAB1Stabilin 1. (2579 aa)
SPRED1Sprouty related EVH1 domain containing 1. (446 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (417 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (966 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (469 aa)
SYNJ2BP-COX16SYNJ2BP-COX16 readthrough. (181 aa)
SARS1Seryl-tRNA synthetase. (539 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
CTNNB1Catenin beta 1. (780 aa)
CNMDChondromodulin. (333 aa)
G3TLN2_LOXAFUncharacterized protein. (182 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1139 aa)
G5E792_LOXAFG_PROTEIN_RECEP_F2_3 domain-containing protein. (803 aa)
HOXA5Homeobox A5. (273 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
E2F2E2F transcription factor 2. (442 aa)
STAT1Signal transducer and activator of transcription. (756 aa)
APOHApolipoprotein H. (346 aa)
NAXENAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (288 aa)
EPN1Epsin 1. (574 aa)
PDE3BPhosphodiesterase. (1112 aa)
ABCC8ATP binding cassette subfamily C member 8. (1540 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
G3U8D7_LOXAFUncharacterized protein. (202 aa)
THBS2Thrombospondin 2. (1173 aa)
NF1Neurofibromin 1. (2840 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (228 aa)
FOXO4Forkhead box O4. (506 aa)
EMILIN1Elastin microfibril interfacer 1. (1011 aa)
MINAR1UPF0258 domain-containing protein. (852 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.