(48 nodes) Intramolecular oxidoreductase activity network (Loxodonta africana)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	PTGIS	Prostaglandin I2 synthase; Belongs to the cytochrome P450 family. (438 aa)
	HSD3B2	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (367 aa)
	PDIA6	Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. (446 aa)
	PDIA4	Protein disulfide isomerase family A member 4; Belongs to the protein disulfide isomerase family. (617 aa)
	PDIA2	Protein disulfide isomerase family A member 2. (467 aa)
	CRELD2	Cysteine rich with EGF like domains 2. (311 aa)
	PDIA3	Protein disulfide-isomerase. (505 aa)
	TXNDC5	Thioredoxin domain containing 5; Belongs to the protein disulfide isomerase family. (344 aa)
	G3U0Q5_LOXAF	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (324 aa)
	ECI2	Enoyl-CoA delta isomerase 2. (390 aa)
	LOC100655872	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (329 aa)
	TPI1	Triosephosphate isomerase. (249 aa)
	G3TL25_LOXAF	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (329 aa)
	EBPL	EBP like. (149 aa)
	ECHS1	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (290 aa)
	ERP44	Endoplasmic reticulum protein 44. (407 aa)
	PTGES	Prostaglandin E synthase. (153 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (778 aa)
	TMX3	Thioredoxin related transmembrane protein 3. (420 aa)
	GPI	Glucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
	PDIA5	Protein disulfide isomerase family A member 5. (518 aa)
	MRI1	Methylthioribose-1-phosphate isomerase 1; Belongs to the eIF-2B alpha/beta/delta subunits family. (312 aa)
	GNPDA2	Glucosamine-6-phosphate deaminase 2. (277 aa)
	EHHADH	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
	QSOX1	Sulfhydryl oxidase. (751 aa)
	ENOPH1	Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (261 aa)
	PTGES3	CS domain-containing protein. (159 aa)
	HPGDS	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa)
	MPI	Mannose-6-phosphate isomerase. (422 aa)
	IDI2	Isopentenyl-diphosphate delta isomerase 2. (227 aa)
	QSOX2	Sulfhydryl oxidase. (609 aa)
	TBXAS1	Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (533 aa)
	G3SW83_LOXAF	EXPERA domain-containing protein. (232 aa)
	ERP27	Endoplasmic reticulum protein 27. (273 aa)
	PTGES2	Prostaglandin E synthase 2; Belongs to the GST superfamily. (363 aa)
	RPIA	Ribose 5-phosphate isomerase A. (310 aa)
	ENOX1	Ecto-NOX disulfide-thiol exchanger 1. (663 aa)
	DDTL	D-dopachrome tautomerase like. (118 aa)
	TXNDC16	Thioredoxin domain containing 16. (822 aa)
	GNPDA1	Glucosamine-6-phosphate isomerase. (289 aa)
	IDI1	Isopentenyl-diphosphate delta isomerase 1. (227 aa)
	PTGDS	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (191 aa)
	MIF	Macrophage migration inhibitory factor. (114 aa)
	DCT	Dopachrome tautomerase. (460 aa)
	HYI	Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. (277 aa)
	P4HB	Protein disulfide-isomerase. (509 aa)
	PDILT	Protein disulfide isomerase like, testis expressed. (575 aa)
	ECI1	Enoyl-CoA delta isomerase 1. (233 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRELD2	PDIA3	ENSLAFP00000025459	ENSLAFP00000023403	Cysteine rich with EGF like domains 2.	Protein disulfide-isomerase.	0.416
CRELD2	PDIA4	ENSLAFP00000025459	ENSLAFP00000026080	Cysteine rich with EGF like domains 2.	Protein disulfide isomerase family A member 4; Belongs to the protein disulfide isomerase family.	0.701
CRELD2	PDIA6	ENSLAFP00000025459	ENSLAFP00000026895	Cysteine rich with EGF like domains 2.	Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family.	0.542
ECHS1	ECI1	ENSLAFP00000015005	ENSLAFP00000000613	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family.	Enoyl-CoA delta isomerase 1.	0.737
ECHS1	ECI2	ENSLAFP00000015005	ENSLAFP00000019694	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family.	Enoyl-CoA delta isomerase 2.	0.546
ECHS1	EHHADH	ENSLAFP00000015005	ENSLAFP00000008072	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.967
ECHS1	G3TL25_LOXAF	ENSLAFP00000015005	ENSLAFP00000015565	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.451
ECHS1	G3U0Q5_LOXAF	ENSLAFP00000015005	ENSLAFP00000021413	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.453
ECHS1	LOC100655872	ENSLAFP00000015005	ENSLAFP00000018997	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.452
ECHS1	TPI1	ENSLAFP00000015005	ENSLAFP00000018313	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family.	Triosephosphate isomerase.	0.406
ECI1	ECHS1	ENSLAFP00000000613	ENSLAFP00000015005	Enoyl-CoA delta isomerase 1.	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family.	0.737
ECI1	ECI2	ENSLAFP00000000613	ENSLAFP00000019694	Enoyl-CoA delta isomerase 1.	Enoyl-CoA delta isomerase 2.	0.984
ECI1	EHHADH	ENSLAFP00000000613	ENSLAFP00000008072	Enoyl-CoA delta isomerase 1.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.917
ECI1	G3TL25_LOXAF	ENSLAFP00000000613	ENSLAFP00000015565	Enoyl-CoA delta isomerase 1.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.569
ECI1	G3U0Q5_LOXAF	ENSLAFP00000000613	ENSLAFP00000021413	Enoyl-CoA delta isomerase 1.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.569
ECI1	LOC100655872	ENSLAFP00000000613	ENSLAFP00000018997	Enoyl-CoA delta isomerase 1.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.568
ECI2	ECHS1	ENSLAFP00000019694	ENSLAFP00000015005	Enoyl-CoA delta isomerase 2.	Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family.	0.546
ECI2	ECI1	ENSLAFP00000019694	ENSLAFP00000000613	Enoyl-CoA delta isomerase 2.	Enoyl-CoA delta isomerase 1.	0.984
ECI2	EHHADH	ENSLAFP00000019694	ENSLAFP00000008072	Enoyl-CoA delta isomerase 2.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.964
ECI2	G3TL25_LOXAF	ENSLAFP00000019694	ENSLAFP00000015565	Enoyl-CoA delta isomerase 2.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.717

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