STRINGSTRING
RUBCNL RUBCNL SPHK2 SPHK2 HTR2A HTR2A AMBRA1 AMBRA1 LACTB LACTB FGFR4 FGFR4 FITM2 FITM2 FLT1 FLT1 KAT5 KAT5 MTOR MTOR ZMPSTE24 ZMPSTE24 MTMR9 MTMR9 SLC45A3 SLC45A3 DKKL1 DKKL1 FMO2 FMO2 ABHD6 ABHD6 PDGFRB PDGFRB IDH1 IDH1 NR4A3 NR4A3 CD81 CD81 RDH10 RDH10 RUBCN RUBCN ASXL3 ASXL3 VAV3 VAV3 ATG14 ATG14 LPGAT1 LPGAT1 ABCG4 ABCG4 PPARD PPARD CD74 CD74 H6PD H6PD PRKAA1 PRKAA1 ELOVL5 ELOVL5 SCARB1 SCARB1 ACADVL ACADVL PRMT3 PRMT3 ERLIN1 ERLIN1 RORC RORC PLIN5 PLIN5 GPS2 GPS2 PHB2 PHB2 HCAR1 HCAR1 IGFBP7 IGFBP7 CCN1 CCN1 FGF21 FGF21 FMO1 FMO1 PDK3 PDK3 CCL21 CCL21 PROX1 PROX1 TM6SF2 TM6SF2 SPHK1 SPHK1 SREBF1 SREBF1 THRSP THRSP STOML2 STOML2 FGFR3 FGFR3 MFSD2A MFSD2A G3TTA5_LOXAF G3TTA5_LOXAF SCAP SCAP G3TUG9_LOXAF G3TUG9_LOXAF PRKCD PRKCD THRA THRA WNT4 WNT4 APOC2 APOC2 G3TWY0_LOXAF G3TWY0_LOXAF DGKZ DGKZ DNAJC19 DNAJC19 TEK TEK CAV1 CAV1 ETFBKMT ETFBKMT CLCN2 CLCN2 G3TZS1_LOXAF G3TZS1_LOXAF G3TZT1_LOXAF G3TZT1_LOXAF ARMC5 ARMC5 APOBEC1 APOBEC1 PTGS2 PTGS2 PLA2G6 PLA2G6 FGF1 FGF1 EPHX2 EPHX2 PTK2B PTK2B SEC14L3 SEC14L3 DAGLB DAGLB PDK1 PDK1 GIP GIP IFNG IFNG DKK3 DKK3 DNAJC15 DNAJC15 SCP2 SCP2 DGKQ DGKQ IL1B IL1B DISP3 DISP3 ADIPOQ ADIPOQ ABCD2 ABCD2 LPCAT3 LPCAT3 MTMR4 MTMR4 INSIG2 INSIG2 SORBS1 SORBS1 PIK3IP1 PIK3IP1 ZBTB20 ZBTB20 CIDEA CIDEA ANGPTL3 ANGPTL3 SIRT4 SIRT4 STAR STAR PLCG2 PLCG2 CCDC3 CCDC3 ACSL3 ACSL3 ORMDL3 ORMDL3 CRTC3 CRTC3 SIK1 SIK1 PIP4K2A PIP4K2A CTDNEP1 CTDNEP1 CGA CGA BSCL2 BSCL2 MID1IP1 MID1IP1 PSAP PSAP RORA RORA LDLR LDLR DHCR7 DHCR7 DDX20 DDX20 STARD4 STARD4 SEC14L5 SEC14L5 BBS4 BBS4 TRIB3 TRIB3 CYP7A1 CYP7A1 ABCB11 ABCB11 LAMTOR1 LAMTOR1 WDTC1 WDTC1 CREBL2 CREBL2 SF1 SF1 MACROH2A1 MACROH2A1 TGFB1 TGFB1 ORMDL1 ORMDL1 PDGFB PDGFB LYN LYN DAB2IP DAB2IP LPIN1 LPIN1 FGF2 FGF2 ABHD5 ABHD5 MLYCD MLYCD MTMR2 MTMR2 NR1H2 NR1H2 ASAH1 ASAH1 G3T2K6_LOXAF G3T2K6_LOXAF SORL1 SORL1 LOC100660588 LOC100660588 NCOA2 NCOA2 PIBF1 PIBF1 PPARA PPARA TTC39B TTC39B STAT5B STAT5B STAT5A STAT5A LONP2 LONP2 NOD2 NOD2 APPL2 APPL2 APOE APOE DAB2 DAB2 FMO5 FMO5 NR1H4 NR1H4 ABCG1 ABCG1 ANXA1 ANXA1 APOB APOB BCL11B BCL11B NR1H3 NR1H3 PCK1 PCK1 SIRT1 SIRT1 SNAI2 SNAI2 ADGRF5 ADGRF5 NFKB1 NFKB1 PIK3R4 PIK3R4 DHH DHH APOA5 APOA5 F2 F2 SIRT3 SIRT3 G3U4G1_LOXAF G3U4G1_LOXAF EGR1 EGR1 SERPINA12 SERPINA12 PDE3B PDE3B SIRT6 SIRT6 GPER1 GPER1 VAV2 VAV2 HTR2B HTR2B LEP LEP CYP27B1 CYP27B1 FMC1 FMC1 AVIL AVIL PDGFRA PDGFRA ERFE ERFE ZFP69B ZFP69B LHCGR LHCGR PDK4 PDK4 GPLD1 GPLD1 ERLIN2 ERLIN2 LPCAT1 LPCAT1 MTMR3 MTMR3 ARV1 ARV1 PDGFA PDGFA ANKRD26 ANKRD26 EPHA8 EPHA8 APOD APOD GOLM1 GOLM1 EIF6 EIF6 ACER1 ACER1 PLA2G3 PLA2G3 CNEP1R1 CNEP1R1 CREB1 CREB1 SAMD8 SAMD8 BMP6 BMP6 BRCA1 BRCA1 FMO4 FMO4 SREBF2 SREBF2 MBOAT7 MBOAT7 MTMR1 MTMR1 CERS2 CERS2 PIP4K2C PIP4K2C ENPP7 ENPP7 ORMDL2 ORMDL2 SNAI1 SNAI1 TTC39A TTC39A NCOR1 NCOR1 MLXIPL MLXIPL PDK2 PDK2 FABP5 FABP5 G3UIG1_LOXAF G3UIG1_LOXAF NR1D2 NR1D2 PIP4K2B PIP4K2B ABCD1 ABCD1 G3UGT0_LOXAF G3UGT0_LOXAF TYSND1 TYSND1 STUB1 STUB1 FGR FGR G3UEB2_LOXAF G3UEB2_LOXAF IGF1R IGF1R CCL19 CCL19 G3UC04_LOXAF G3UC04_LOXAF WASHC1 WASHC1 INSIG1 INSIG1 MALRD1 MALRD1 G3UA36_LOXAF G3UA36_LOXAF REST REST NR0B1 NR0B1 PPARG PPARG ANGPTL8 ANGPTL8 NR1D1 NR1D1 RARRES2 RARRES2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
RUBCNLRubicon like autophagy enhancer. (691 aa)
SPHK2Sphingosine kinase 2. (615 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
AMBRA1WD_REPEATS_REGION domain-containing protein. (766 aa)
LACTBLactamase beta. (433 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
FITM2Fat storage inducing transmembrane protein 2. (262 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (545 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
MTMR9Myotubularin related protein 9. (545 aa)
SLC45A3Solute carrier family 45 member 3. (552 aa)
DKKL1Dickkopf like acrosomal protein 1. (233 aa)
FMO2Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
ABHD6Abhydrolase domain containing 6. (338 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (420 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (626 aa)
CD81Tetraspanin. (214 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (342 aa)
RUBCNRubicon autophagy regulator. (957 aa)
ASXL3ASXL transcriptional regulator 3. (2181 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
ATG14Autophagy related 14. (492 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (385 aa)
ABCG4ATP binding cassette subfamily G member 4. (645 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
CD74CD74 molecule. (280 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (796 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (300 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (361 aa)
ACADVLAcyl-CoA dehydrogenase very long chain. (655 aa)
PRMT3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (449 aa)
ERLIN1ER lipid raft associated 1. (350 aa)
RORCRAR related orphan receptor C. (517 aa)
PLIN5Perilipin; Belongs to the perilipin family. (371 aa)
GPS2G protein pathway suppressor 2. (327 aa)
PHB2Prohibitin. (300 aa)
HCAR1Hydroxycarboxylic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (299 aa)
IGFBP7Insulin like growth factor binding protein 7. (283 aa)
CCN1Cellular communication network factor 1. (383 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FMO1Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
CCL21SCY domain-containing protein. (110 aa)
PROX1Prospero homeobox 1. (737 aa)
TM6SF2Transmembrane 6 superfamily member 2. (377 aa)
SPHK1Sphingosine kinase 1. (386 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1087 aa)
THRSPThyroid hormone responsive. (150 aa)
STOML2Stomatin like 2. (357 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (531 aa)
G3TTA5_LOXAFUncharacterized protein. (152 aa)
SCAPSREBF chaperone. (1285 aa)
G3TUG9_LOXAFFlavin-containing monooxygenase. (178 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (701 aa)
THRAThyroid hormone receptor alpha. (487 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
APOC2Apolipoprotein C2. (101 aa)
G3TWY0_LOXAFUncharacterized protein. (88 aa)
DGKZDiacylglycerol kinase. (1118 aa)
DNAJC19Uncharacterized protein. (129 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (185 aa)
ETFBKMTElectron transfer flavoprotein subunit beta lysine methyltransferase. (266 aa)
CLCN2Chloride channel protein. (902 aa)
G3TZS1_LOXAFPlsC domain-containing protein. (488 aa)
G3TZT1_LOXAFUncharacterized protein. (294 aa)
ARMC5Armadillo repeat containing 5. (925 aa)
APOBEC1Apolipoprotein B mRNA editing enzyme catalytic subunit 1. (223 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PLA2G6Phospholipase A2 group VI. (808 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
EPHX2Epoxide hydrolase 2. (558 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1011 aa)
SEC14L3SEC14 like lipid binding 3. (400 aa)
DAGLBLipase_3 domain-containing protein. (354 aa)
PDK1Protein-serine/threonine kinase. (389 aa)
GIPGastric inhibitory polypeptide. (144 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (282 aa)
DNAJC15DnaJ heat shock protein family (Hsp40) member C15. (146 aa)
SCP2Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (515 aa)
DGKQDiacylglycerol kinase. (850 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (262 aa)
DISP3Dispatched RND transporter family member 3. (1389 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (245 aa)
ABCD2ATP binding cassette subfamily D member 2. (742 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (487 aa)
MTMR4Myotubularin related protein 4. (1198 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
SORBS1Sorbin and SH3 domain containing 1. (1291 aa)
PIK3IP1Phosphoinositide-3-kinase interacting protein 1. (262 aa)
ZBTB20Zinc finger and BTB domain containing 20. (743 aa)
CIDEACell death inducing DFFA like effector a. (217 aa)
ANGPTL3Angiopoietin like 3. (454 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (312 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CCDC3Coiled-coil domain containing 3. (256 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
CRTC3CREB regulated transcription coactivator 3. (547 aa)
SIK1Uncharacterized protein. (795 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (405 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (245 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (121 aa)
BSCL2BSCL2 lipid droplet biogenesis associated, seipin. (381 aa)
MID1IP1MID1 interacting protein 1. (183 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (527 aa)
RORARAR related orphan receptor A. (467 aa)
LDLRLow density lipoprotein receptor. (858 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
DDX20DEAD-box helicase 20; Belongs to the DEAD box helicase family. (800 aa)
STARD4StAR related lipid transfer domain containing 4. (209 aa)
SEC14L5SEC14 like lipid binding 5. (633 aa)
BBS4Bardet-Biedl syndrome 4. (506 aa)
TRIB3Tribbles pseudokinase 3. (358 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (503 aa)
ABCB11ATP binding cassette subfamily B member 11. (1324 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
WDTC1WD and tetratricopeptide repeats 1. (677 aa)
CREBL2cAMP responsive element binding protein like 2. (170 aa)
SF1Splicing factor 1. (645 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ORMDL1ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
LYNTyrosine-protein kinase. (512 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
LPIN1Lipin 1. (929 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (96 aa)
ABHD5Abhydrolase domain containing 5. (345 aa)
MLYCDMalonyl-CoA decarboxylase. (497 aa)
MTMR2Myotubularin related protein 2. (617 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (454 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (394 aa)
G3T2K6_LOXAFMyotubularin phosphatase domain-containing protein. (520 aa)
SORL1Sortilin related receptor 1. (2220 aa)
LOC100660588Dimethylaniline monooxygenase [N-oxide-forming]. (539 aa)
NCOA2Nuclear receptor coactivator. (1461 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (730 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
TTC39BTetratricopeptide repeat domain 39B. (556 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (853 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1020 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
APOEApolipoprotein E. (314 aa)
DAB2DAB adaptor protein 2. (768 aa)
FMO5Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
ABCG1ATP binding cassette subfamily G member 1. (666 aa)
ANXA1Annexin. (348 aa)
APOBApolipoprotein B. (3100 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (883 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (447 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (624 aa)
SIRT1Sirtuin 1. (605 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1271 aa)
NFKB1Nuclear factor kappa B subunit 1. (973 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1359 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
APOA5Apolipoprotein A5. (371 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (619 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (257 aa)
G3U4G1_LOXAFIg-like domain-containing protein. (504 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (548 aa)
SERPINA12Serpin family A member 12; Belongs to the serpin family. (413 aa)
PDE3BPhosphodiesterase. (1112 aa)
SIRT6Sirtuin 6. (336 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
VAV2Vav guanine nucleotide exchange factor 2. (866 aa)
HTR2B5-hydroxytryptamine receptor 2B. (477 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
FMC1Formation of mitochondrial complex V assembly factor 1 homolog. (113 aa)
AVILAdvillin. (822 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1091 aa)
ERFEErythroferrone. (331 aa)
ZFP69BZFP69 zinc finger protein B. (417 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (631 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (840 aa)
ERLIN2ER lipid raft associated 2. (339 aa)
LPCAT1Uncharacterized protein. (477 aa)
MTMR3Myotubularin related protein 3. (1204 aa)
ARV1ARV1 homolog, fatty acid homeostasis modulator. (271 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (191 aa)
ANKRD26Ankyrin repeat domain 26. (1604 aa)
EPHA8EPH receptor A8. (974 aa)
APODApolipoprotein D. (190 aa)
GOLM1Golgi membrane protein 1. (364 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (233 aa)
PLA2G3Phospholipase A2 group III. (494 aa)
CNEP1R1CTD nuclear envelope phosphatase 1 regulatory subunit 1. (125 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SAMD8Sterile alpha motif domain containing 8. (467 aa)
BMP6Bone morphogenetic protein 6. (298 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1854 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (555 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1109 aa)
MBOAT7Membrane bound O-acyltransferase domain containing 7; Belongs to the membrane-bound acyltransferase family. (471 aa)
MTMR1Myotubularin related protein 1. (620 aa)
CERS2Ceramide synthase 2. (389 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (422 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (401 aa)
ORMDL2ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
TTC39ATetratricopeptide repeat domain 39A. (585 aa)
NCOR1Nuclear receptor corepressor 1. (2457 aa)
MLXIPLMLX interacting protein like. (860 aa)
PDK2Protein-serine/threonine kinase. (362 aa)
FABP5Fatty acid binding protein 5. (134 aa)
G3UIG1_LOXAFJ domain-containing protein. (116 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (576 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (424 aa)
ABCD1ATP binding cassette subfamily D member 1. (739 aa)
G3UGT0_LOXAFUncharacterized protein. (152 aa)
TYSND1Trypsin domain containing 1. (455 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
FGRTyrosine-protein kinase. (527 aa)
G3UEB2_LOXAFUncharacterized protein. (544 aa)
IGF1RTyrosine-protein kinase receptor. (1161 aa)
CCL19C-C motif chemokine. (103 aa)
G3UC04_LOXAFUncharacterized protein. (327 aa)
WASHC1WASH complex subunit 1. (474 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (263 aa)
MALRD1Uncharacterized protein. (351 aa)
G3UA36_LOXAFUncharacterized protein. (403 aa)
RESTRE1 silencing transcription factor. (1067 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (471 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ANGPTL8Angiopoietin like 8. (198 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (611 aa)
RARRES2Retinoic acid receptor responder 2. (163 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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