STRINGSTRING
RAB44 RAB44 STXBP1 STXBP1 SNAPIN SNAPIN GATA3 GATA3 RAB11FIP2 RAB11FIP2 RPH3AL RPH3AL SYT5 SYT5 SELENOT SELENOT TMF1 TMF1 GLP1R GLP1R STX1B STX1B SLC16A2 SLC16A2 SYN2 SYN2 DOC2A DOC2A PCLO PCLO P2RX1 P2RX1 SYT9 SYT9 SNAP23 SNAP23 RPH3A RPH3A PTGS2 PTGS2 SYTL4 SYTL4 VIP VIP SLC30A8 SLC30A8 EDN1 EDN1 G3T030_LOXAF G3T030_LOXAF LYN LYN G3T0V1_LOXAF G3T0V1_LOXAF SLC44A4 SLC44A4 DGKI DGKI STX19 STX19 ANXA1 ANXA1 RIMS2 RIMS2 RAPGEF4 RAPGEF4 LIN7C LIN7C AQP1 AQP1 SYT4 SYT4 RIMS3 RIMS3 SNAP29 SNAP29 CADPS CADPS LEP LEP PDZD11 PDZD11 CCDC186 CCDC186 SYNJ1 SYNJ1 SYK SYK PARK7 PARK7 CDK16 CDK16 SYT8 SYT8 EDNRB EDNRB STX4 STX4 CREB1 CREB1 SYT12 SYT12 SYT1 SYT1 HIF1A HIF1A PINK1 PINK1 LIN7B LIN7B SNAP25 SNAP25 SYN3 SYN3 NT5DC2 NT5DC2 ADCYAP1 ADCYAP1 LRRC1 LRRC1 LIN7A LIN7A FFAR4 FFAR4 SLC16A10 SLC16A10 SNX19 SNX19 DOC2B DOC2B GHRHR GHRHR NT5DC3 NT5DC3 GHSR GHSR BTK BTK STXBP3 STXBP3 NIBAN2 NIBAN2 HNF1A HNF1A CPLX4 CPLX4 SYN1 SYN1 ERC2 ERC2 SYT2 SYT2 CPLX2 CPLX2 CPLX3 CPLX3 P2RX7 P2RX7 WLS WLS ACVR1C ACVR1C SREBF1 SREBF1 LOC100666284 LOC100666284 STX1A STX1A RBM4 RBM4 G3TXD8_LOXAF G3TXD8_LOXAF STXBP2 STXBP2 EXOC3L1 EXOC3L1 UNC13B UNC13B BRAF BRAF CYB5R4 CYB5R4 GPR119 GPR119 UNC13C UNC13C INHBA INHBA HNF1B HNF1B SNAP47 SNAP47 G3U5L2_LOXAF G3U5L2_LOXAF STX2 STX2 CADPS2 CADPS2 RIMS2-2 RIMS2-2 PSEN1 PSEN1 NF1 NF1 FFAR1 FFAR1 LTBP4 LTBP4 KCNQ1 KCNQ1 VGF VGF SYT7 SYT7 PORCN PORCN FZD4 FZD4 NOS2 NOS2 G3UEY1_LOXAF G3UEY1_LOXAF TRPV4 TRPV4 GHRH GHRH PPFIA3 PPFIA3 DVL1 DVL1 G3UJ64_LOXAF G3UJ64_LOXAF STX3 STX3 PRRT2 PRRT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB44Uncharacterized protein. (175 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
GATA3GATA binding protein 3. (443 aa)
RAB11FIP2RAB11 family interacting protein 2. (506 aa)
RPH3ALRabphilin 3A like (without C2 domains). (293 aa)
SYT5Synaptotagmin 5. (386 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (195 aa)
TMF1TATA element modulatory factor 1. (1093 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (464 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (288 aa)
SLC16A2Solute carrier family 16 member 2. (522 aa)
SYN2Synapsin II. (579 aa)
DOC2ADouble C2-like domain-containing protein. (401 aa)
PCLOPiccolo presynaptic cytomatrix protein. (4746 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
SYT9Synaptotagmin 9. (491 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
RPH3ARabphilin 3A. (613 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
SYTL4Synaptotagmin like 4. (672 aa)
VIPVasoactive intestinal peptide. (170 aa)
SLC30A8Solute carrier family 30 member 8. (328 aa)
EDN1Endothelin 1. (202 aa)
G3T030_LOXAFUncharacterized protein. (796 aa)
LYNTyrosine-protein kinase. (512 aa)
G3T0V1_LOXAFUncharacterized protein. (274 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (705 aa)
DGKIDiacylglycerol kinase. (855 aa)
STX19Syntaxin 19; Belongs to the syntaxin family. (294 aa)
ANXA1Annexin. (348 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1077 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
LIN7CProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
SYT4Synaptotagmin 4. (428 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (309 aa)
SNAP29Synaptosome associated protein 29. (255 aa)
CADPSCalcium dependent secretion activator. (1355 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
PDZD11PDZ domain containing 11. (140 aa)
CCDC186Coiled-coil domain containing 186. (915 aa)
SYNJ1Synaptojanin 1. (1581 aa)
SYKTyrosine-protein kinase. (629 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
CDK16Cyclin dependent kinase 16; Belongs to the protein kinase superfamily. (492 aa)
SYT8Synaptotagmin 8. (400 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
STX4Syntaxin 4. (299 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SYT12Synaptotagmin 12. (421 aa)
SYT1Synaptotagmin 1. (422 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (836 aa)
PINK1PTEN induced kinase 1. (582 aa)
LIN7BProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (207 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
SYN3Synapsin III. (342 aa)
NT5DC25'-nucleotidase domain containing 2. (483 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
LIN7AProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
FFAR4Free fatty acid receptor 4. (361 aa)
SLC16A10Solute carrier family 16 member 10. (515 aa)
SNX19Sorting nexin 19. (1004 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
GHRHRGrowth hormone releasing hormone receptor. (375 aa)
NT5DC35'-nucleotidase domain containing 3. (479 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
BTKTyrosine-protein kinase. (661 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (591 aa)
NIBAN2Niban apoptosis regulator 2. (747 aa)
HNF1AHNF1 homeobox A. (631 aa)
CPLX4Complexin 4. (160 aa)
SYN1Synapsin I. (578 aa)
ERC2Uncharacterized protein. (358 aa)
SYT2Synaptotagmin 2. (419 aa)
CPLX2Complexin 2. (134 aa)
CPLX3Complexin 3. (156 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (599 aa)
WLSWnt ligand secretion mediator. (541 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (470 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1087 aa)
LOC100666284Interleukin-1. (175 aa)
STX1ASyntaxin 1A. (282 aa)
RBM4RNA binding motif protein 4. (365 aa)
G3TXD8_LOXAFUncharacterized protein. (147 aa)
STXBP2Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (593 aa)
EXOC3L1Exocyst complex component 3 like 1. (730 aa)
UNC13BUnc-13 homolog B. (1989 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (740 aa)
CYB5R4Cytochrome b5 reductase 4. (522 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (335 aa)
UNC13CUncharacterized protein. (1413 aa)
INHBAInhibin subunit beta A. (422 aa)
HNF1BHNF1 homeobox B. (560 aa)
SNAP47Synaptosome associated protein 47. (420 aa)
G3U5L2_LOXAFC2 domain-containing protein. (375 aa)
STX2Syntaxin 2; Belongs to the syntaxin family. (288 aa)
CADPS2Calcium dependent secretion activator 2. (1301 aa)
RIMS2-2Uncharacterized protein. (171 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (440 aa)
NF1Neurofibromin 1. (2840 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1619 aa)
KCNQ1Ion_trans domain-containing protein; Belongs to the potassium channel family. (332 aa)
VGFVGF nerve growth factor inducible. (538 aa)
SYT7Synaptotagmin 7. (576 aa)
PORCNPorcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (437 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1155 aa)
G3UEY1_LOXAFUncharacterized protein. (441 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (739 aa)
GHRHGrowth hormone releasing hormone. (107 aa)
PPFIA3PTPRF interacting protein alpha 3. (1242 aa)
DVL1Dishevelled segment polarity protein 1. (621 aa)
G3UJ64_LOXAFUncharacterized protein. (1460 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (280 aa)
PRRT2Uncharacterized protein. (403 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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