(87 nodes) Cortical cytoskeleton network (Loxodonta africana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPP1R9B	Protein phosphatase 1 regulatory subunit 9B. (473 aa)
	SHROOM1	Shroom family member 1. (841 aa)
	ERC1	ELKS/RAB6-interacting/CAST family member 1. (1074 aa)
	ACTN1	Actinin alpha 1. (892 aa)
	TRPC4	Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (978 aa)
	MYRIP	Myosin VIIA and Rab interacting protein. (749 aa)
	LLGL1	LLGL scribble cell polarity complex component 1. (1003 aa)
	MAEA	Macrophage erythroblast attacher. (396 aa)
	COBL	Uncharacterized protein. (1001 aa)
	MYADM	Myeloid associated differentiation marker. (322 aa)
	DBNL	Drebrin like. (428 aa)
	PPP1R9A	Protein phosphatase 1 regulatory subunit 9A. (1089 aa)
	PCLO	Piccolo presynaptic cytomatrix protein. (4746 aa)
	NUMA1	Nuclear mitotic apparatus protein 1. (2119 aa)
	CAP1	Adenylyl cyclase-associated protein; Belongs to the CAP family. (451 aa)
	UTRN	Utrophin. (3097 aa)
	CLASP1	Cytoplasmic linker associated protein 1. (1539 aa)
	TMOD1	Tropomodulin 1. (359 aa)
	SLC4A1	Anion exchange protein. (904 aa)
	G3T030_LOXAF	Uncharacterized protein. (796 aa)
	SPTB	Spectrin beta chain; Belongs to the spectrin family. (2329 aa)
	PLEKHH2	Pleckstrin homology, MyTH4 and FERM domain containing H2. (1493 aa)
	PLS1	Plastin 1. (632 aa)
	RIMS2	Regulating synaptic membrane exocytosis 2. (1077 aa)
	RIMS3	Regulating synaptic membrane exocytosis 3. (309 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
	LLGL2	LLGL scribble cell polarity complex component 2. (1028 aa)
	MPP1	Membrane palmitoylated protein 1; Belongs to the MAGUK family. (424 aa)
	SPTBN1	Spectrin beta chain; Belongs to the spectrin family. (2364 aa)
	SPTA1	Spectrin alpha, erythrocytic 1. (2392 aa)
	ANLN	Anillin actin binding protein. (1127 aa)
	G3TA05_LOXAF	Uncharacterized protein. (565 aa)
	G3TAJ4_LOXAF	Uncharacterized protein. (2013 aa)
	ACTN2	Actinin alpha 2. (896 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (493 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (481 aa)
	MAPRE1	Microtubule associated protein RP/EB family member 1. (268 aa)
	DMTN	Dematin actin binding protein. (384 aa)
	DSTN	Destrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (164 aa)
	PJVK	Pejvakin. (352 aa)
	MLPH	Melanophilin. (600 aa)
	CTTN	Cortactin. (550 aa)
	GYPC	Uncharacterized protein. (100 aa)
	ERC2	Uncharacterized protein. (358 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
	SHROOM3	Shroom family member 3. (1877 aa)
	SHROOM2	Shroom family member 2. (1440 aa)
	VCL	Vinculin. (1066 aa)
	NF2	Neurofibromin 2. (596 aa)
	G3TRN6_LOXAF	Uncharacterized protein. (314 aa)
	ACTN4	Actinin alpha 4. (898 aa)
	BSN	Bassoon presynaptic cytomatrix protein. (3769 aa)
	G3TVZ7_LOXAF	Uncharacterized protein. (49 aa)
	MOBP	Myelin associated oligodendrocyte basic protein. (151 aa)
	CALD1	Caldesmon 1. (530 aa)
	WASL	WASP like actin nucleation promoting factor. (505 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (459 aa)
	G3U099_LOXAF	ZZ-type domain-containing protein. (533 aa)
	WDR1	WD repeat domain 1. (632 aa)
	NSMF	NMDA receptor synaptonuclear signaling and neuronal migration factor. (482 aa)
	G3U5T7_LOXAF	ASD2 domain-containing protein. (243 aa)
	EPB41	Erythrocyte membrane protein band 4.1. (858 aa)
	KNCN	Kinocilin. (124 aa)
	G3U6K7_LOXAF	PH domain-containing protein. (1231 aa)
	MYO1A	Myosin IA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1104 aa)
	RIMS2-2	Uncharacterized protein. (171 aa)
	G3U908_LOXAF	Uncharacterized protein. (355 aa)
	MTSS2	MTSS I-BAR domain containing 2. (753 aa)
	DBN1	Drebrin 1. (677 aa)
	SPTBN2	Spectrin beta chain; Belongs to the spectrin family. (2393 aa)
	CAPZA3	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (299 aa)
	CIB2	Calcium and integrin binding family member 2. (190 aa)
	SPTAN1	Spectrin alpha, non-erythrocytic 1. (2478 aa)
	HCLS1	Hematopoietic cell-specific Lyn substrate 1. (487 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (429 aa)
	DLC1	DLC1 Rho GTPase activating protein. (1123 aa)
	COTL1	Coactosin like F-actin binding protein 1. (106 aa)
	KRT19	Keratin 19; Belongs to the intermediate filament family. (389 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1155 aa)
	G3UEY1_LOXAF	Uncharacterized protein. (441 aa)
	TRPV4	Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (739 aa)
	G3UGR5_LOXAF	Uncharacterized protein. (65 aa)
	G3UH64_LOXAF	ASD2 domain-containing protein. (264 aa)
	G3UK33_LOXAF	Uncharacterized protein. (77 aa)
	CAPZA2	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (289 aa)
	GSN	Gelsolin. (782 aa)
	G3UMV6_LOXAF	Uncharacterized protein. (50 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN1	G3U6K7_LOXAF	ENSLAFP00000000587	ENSLAFP00000023465	Actinin alpha 1.	PH domain-containing protein.	0.784
ACTN1	TMOD1	ENSLAFP00000000587	ENSLAFP00000005025	Actinin alpha 1.	Tropomodulin 1.	0.437
ACTN1	VCL	ENSLAFP00000000587	ENSLAFP00000017626	Actinin alpha 1.	Vinculin.	0.751
ACTN2	DLG4	ENSLAFP00000011919	ENSLAFP00000015624	Actinin alpha 2.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.436
ACTN2	G3U6K7_LOXAF	ENSLAFP00000011919	ENSLAFP00000023465	Actinin alpha 2.	PH domain-containing protein.	0.760
ACTN2	TMOD1	ENSLAFP00000011919	ENSLAFP00000005025	Actinin alpha 2.	Tropomodulin 1.	0.440
ACTN2	VCL	ENSLAFP00000011919	ENSLAFP00000017626	Actinin alpha 2.	Vinculin.	0.777
ACTN4	G3U6K7_LOXAF	ENSLAFP00000019301	ENSLAFP00000023465	Actinin alpha 4.	PH domain-containing protein.	0.810
ACTN4	TMOD1	ENSLAFP00000019301	ENSLAFP00000005025	Actinin alpha 4.	Tropomodulin 1.	0.437
ACTN4	VCL	ENSLAFP00000019301	ENSLAFP00000017626	Actinin alpha 4.	Vinculin.	0.751
ANLN	FLOT1	ENSLAFP00000010619	ENSLAFP00000025347	Anillin actin binding protein.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.472
ANLN	FLOT2	ENSLAFP00000010619	ENSLAFP00000012769	Anillin actin binding protein.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.519
BSN	DLG4	ENSLAFP00000019605	ENSLAFP00000015624	Bassoon presynaptic cytomatrix protein.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.406
BSN	ERC1	ENSLAFP00000019605	ENSLAFP00000000071	Bassoon presynaptic cytomatrix protein.	ELKS/RAB6-interacting/CAST family member 1.	0.404
BSN	ERC2	ENSLAFP00000019605	ENSLAFP00000015349	Bassoon presynaptic cytomatrix protein.	Uncharacterized protein.	0.484
BSN	G3UEY1_LOXAF	ENSLAFP00000019605	ENSLAFP00000026389	Bassoon presynaptic cytomatrix protein.	Uncharacterized protein.	0.484
BSN	PCLO	ENSLAFP00000019605	ENSLAFP00000004465	Bassoon presynaptic cytomatrix protein.	Piccolo presynaptic cytomatrix protein.	0.574
CAP1	COTL1	ENSLAFP00000004695	ENSLAFP00000025839	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Coactosin like F-actin binding protein 1.	0.573
CAP1	DBN1	ENSLAFP00000004695	ENSLAFP00000024641	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Drebrin 1.	0.740
CAP1	DBNL	ENSLAFP00000004695	ENSLAFP00000003912	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Drebrin like.	0.740

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