STRINGSTRING
IL1A IL1A PRKCQ PRKCQ PLCG2 PLCG2 PTPRC PTPRC CLEC7A CLEC7A IL1B IL1B RPS3 RPS3 CARD11 CARD11 SASH3 SASH3 VTCN1 VTCN1 ANXA1 ANXA1 STAT5B STAT5B STAT5A STAT5A CD83 CD83 MALT1 MALT1 PDE4B PDE4B MAP3K7 MAP3K7 STOML2 STOML2 TRAF6 TRAF6 RIPK2 RIPK2 GLMN GLMN G3UDK1_LOXAF G3UDK1_LOXAF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1291 aa)
CLEC7AC-type lectin domain containing 7A. (246 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (262 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
CARD11Caspase recruitment domain family member 11. (1159 aa)
SASH3SAM and SH3 domain containing 3. (375 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (280 aa)
ANXA1Annexin. (348 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
CD83CD83 molecule. (206 aa)
MALT1MALT1 paracaspase. (834 aa)
PDE4BPhosphodiesterase. (642 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
STOML2Stomatin like 2. (357 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
GLMNGlomulin, FKBP associated protein. (599 aa)
G3UDK1_LOXAFIg-like domain-containing protein. (228 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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