(44 nodes) Regulation of toll-like receptor signaling pathway network (Loxodonta africana)

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Your Input:
	PJA2	Praja ring finger ubiquitin ligase 2. (709 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (907 aa)
	CXorf21	Chromosome X open reading frame 21. (300 aa)
	G3SRX5_LOXAF	Ig-like domain-containing protein. (305 aa)
	WDFY1	Uncharacterized protein. (411 aa)
	CYBA	Cytochrome b-245 alpha chain. (169 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (588 aa)
	IRF1	Interferon regulatory factor. (326 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	NFKBIL1	NFKB inhibitor like 1. (382 aa)
	DAB2IP	DAB2 interacting protein. (1189 aa)
	SMPDL3B	Acid sphingomyelinase-like phosphodiesterase. (456 aa)
	MFHAS1	Malignant fibrous histiocytoma amplified sequence 1. (1052 aa)
	LRRC14	Leucine rich repeat containing 14. (495 aa)
	TIRAP	TIR domain containing adaptor protein. (221 aa)
	BPIFB1	BPI fold containing family B member 1. (475 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	NLRP6	Uncharacterized protein. (732 aa)
	OTUD4	OTU deubiquitinase 4. (1000 aa)
	RTN4	Reticulon. (1011 aa)
	G3T8M4_LOXAF	Ig-like domain-containing protein. (324 aa)
	ACOD1	Aconitate decarboxylase 1. (488 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1020 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (662 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
	ESR1	NR LBD domain-containing protein. (232 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (360 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
	GPS2	G protein pathway suppressor 2. (327 aa)
	SARM1	Sterile alpha and TIR motif containing 1. (721 aa)
	RAB7B	RAB7B, member RAS oncogene family. (200 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (185 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (558 aa)
	TREML4	Ig-like domain-containing protein. (145 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (611 aa)
	CACTIN	Uncharacterized protein. (179 aa)
	NINJ1	Ninjurin 1. (150 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (429 aa)
	IFI35	Interferon induced protein 35. (284 aa)
	TLR9	TIR domain-containing protein. (1030 aa)
	G3UH32_LOXAF	Uncharacterized protein. (361 aa)
	TNFAIP3	TNF alpha induced protein 3. (790 aa)
	GRAMD4	GRAM domain containing 4. (621 aa)
	G3UMR8_LOXAF	Uncharacterized protein. (125 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPL1	APPL2	ENSLAFP00000011973	ENSLAFP00000011876	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.987
APPL1	WDFY1	ENSLAFP00000011973	ENSLAFP00000002874	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Uncharacterized protein.	0.451
APPL2	APPL1	ENSLAFP00000011876	ENSLAFP00000011973	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.987
APPL2	WDFY1	ENSLAFP00000011876	ENSLAFP00000002874	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Uncharacterized protein.	0.451
CAV1	ESR1	ENSLAFP00000020339	ENSLAFP00000012768	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	NR LBD domain-containing protein.	0.725
CAV1	FLOT1	ENSLAFP00000020339	ENSLAFP00000025347	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.607
CAV1	LYN	ENSLAFP00000020339	ENSLAFP00000006556	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Tyrosine-protein kinase.	0.439
ESR1	CAV1	ENSLAFP00000012768	ENSLAFP00000020339	NR LBD domain-containing protein.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.725
ESR1	LYN	ENSLAFP00000012768	ENSLAFP00000006556	NR LBD domain-containing protein.	Tyrosine-protein kinase.	0.468
FLOT1	CAV1	ENSLAFP00000025347	ENSLAFP00000020339	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.607
G3UH32_LOXAF	G3UMR8_LOXAF	ENSLAFP00000027140	ENSLAFP00000029127	Uncharacterized protein.	Uncharacterized protein.	0.900
G3UMR8_LOXAF	G3UH32_LOXAF	ENSLAFP00000029127	ENSLAFP00000027140	Uncharacterized protein.	Uncharacterized protein.	0.900
GPS2	NR1D1	ENSLAFP00000016066	ENSLAFP00000023997	G protein pathway suppressor 2.	Nuclear receptor subfamily 1 group D member 1.	0.765
GPS2	WDFY1	ENSLAFP00000016066	ENSLAFP00000002874	G protein pathway suppressor 2.	Uncharacterized protein.	0.402
IFI35	IRF1	ENSLAFP00000025747	ENSLAFP00000006310	Interferon induced protein 35.	Interferon regulatory factor.	0.458
IFI35	RSAD2	ENSLAFP00000025747	ENSLAFP00000014333	Interferon induced protein 35.	Radical S-adenosyl methionine domain containing 2.	0.506
IRF1	IFI35	ENSLAFP00000006310	ENSLAFP00000025747	Interferon regulatory factor.	Interferon induced protein 35.	0.458
IRF1	RSAD2	ENSLAFP00000006310	ENSLAFP00000014333	Interferon regulatory factor.	Radical S-adenosyl methionine domain containing 2.	0.472
IRF1	TLR3	ENSLAFP00000006310	ENSLAFP00000014729	Interferon regulatory factor.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.668
LGR4	PJA2	ENSLAFP00000001889	ENSLAFP00000001195	Leucine rich repeat containing G protein-coupled receptor 4.	Praja ring finger ubiquitin ligase 2.	0.495

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