(6 nodes) Peptidyl-lysine deacetylation network (Loxodonta africana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (392 aa)
	SIRT1	Sirtuin 1. (605 aa)
	HDAC6	Histone deacetylase 6. (1122 aa)
	SIRT4	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (312 aa)
	HDAC10	Histone deacetylase 10. (652 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (257 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HDAC10	SIRT1	ENSLAFP00000022129	ENSLAFP00000007775	Histone deacetylase 10.	Sirtuin 1.	0.449
HDAC6	SIRT1	ENSLAFP00000003196	ENSLAFP00000007775	Histone deacetylase 6.	Sirtuin 1.	0.500
HDAC6	SIRT2	ENSLAFP00000003196	ENSLAFP00000017245	Histone deacetylase 6.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.580
SIRT1	HDAC10	ENSLAFP00000007775	ENSLAFP00000022129	Sirtuin 1.	Histone deacetylase 10.	0.449
SIRT1	HDAC6	ENSLAFP00000007775	ENSLAFP00000003196	Sirtuin 1.	Histone deacetylase 6.	0.500
SIRT1	SIRT2	ENSLAFP00000007775	ENSLAFP00000017245	Sirtuin 1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.624
SIRT1	SIRT3	ENSLAFP00000007775	ENSLAFP00000022559	Sirtuin 1.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.655
SIRT1	SIRT4	ENSLAFP00000007775	ENSLAFP00000001879	Sirtuin 1.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.592
SIRT2	HDAC6	ENSLAFP00000017245	ENSLAFP00000003196	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Histone deacetylase 6.	0.580
SIRT2	SIRT1	ENSLAFP00000017245	ENSLAFP00000007775	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Sirtuin 1.	0.624
SIRT2	SIRT4	ENSLAFP00000017245	ENSLAFP00000001879	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.696
SIRT3	SIRT1	ENSLAFP00000022559	ENSLAFP00000007775	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	Sirtuin 1.	0.655
SIRT3	SIRT4	ENSLAFP00000022559	ENSLAFP00000001879	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.641
SIRT4	SIRT1	ENSLAFP00000001879	ENSLAFP00000007775	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	Sirtuin 1.	0.592
SIRT4	SIRT2	ENSLAFP00000001879	ENSLAFP00000017245	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.696
SIRT4	SIRT3	ENSLAFP00000001879	ENSLAFP00000022559	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.641

Server load: low (22%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About