97 items (Loxodonta africana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	TFAP2C	Transcription factor AP-2 gamma. (450 aa)
	G3TLC2_LOXAF	Morc6_S5 domain-containing protein. (416 aa)
	CGGBP1	CGG triplet repeat binding protein 1. (167 aa)
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (475 aa)
	G3TPG2_LOXAF	RING-type domain-containing protein. (603 aa)
	YTHDC1	YTH domain containing 1. (730 aa)
	NRM	Nurim. (261 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (824 aa)
	AXIN1	Axin 1. (864 aa)
	DNMT3L	PHD-type domain-containing protein. (379 aa)
	MACROH2A2	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	ARID4B	AT-rich interaction domain 4B. (1312 aa)
	HMGA2	Uncharacterized protein. (108 aa)
	SIRT6	Sirtuin 6. (336 aa)
	DNMT3A	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
	G3U8M1_LOXAF	Uncharacterized protein. (182 aa)
	PHF2	PHD finger protein 2. (1073 aa)
	G3U976_LOXAF	ANK_REP_REGION domain-containing protein. (259 aa)
	CENPV	GFA domain-containing protein. (165 aa)
	KCNQ1	Ion_trans domain-containing protein; Belongs to the potassium channel family. (332 aa)
	GLMN	Glomulin, FKBP associated protein. (599 aa)
	MBD3	Methyl-CpG binding domain protein 3. (269 aa)
	PADI2	Peptidyl arginine deiminase 2. (674 aa)
	G3UEP7_LOXAF	H15 domain-containing protein. (138 aa)
	G3UJJ0_LOXAF	Uncharacterized protein. (423 aa)
	G3UJL8_LOXAF	Uncharacterized protein. (347 aa)
	DOT1L	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1546 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1757 aa)
	RB1	RB transcriptional corepressor 1. (925 aa)
	TNP1	Transition protein 1. (55 aa)
	MTA1	Metastasis associated 1. (660 aa)
	SUZ12	SUZ12 polycomb repressive complex 2 subunit. (739 aa)
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (457 aa)
	FAM172A	Family with sequence similarity 172 member A. (420 aa)
	SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa)
	PPHLN1	Periphilin 1. (304 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1628 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (664 aa)
	PRMT7	Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (696 aa)
	G3SRJ6_LOXAF	Uncharacterized protein. (301 aa)
	SPTY2D1	SPT2 chromatin protein domain containing 1. (678 aa)
	TDG	Thymine DNA glycosylase. (411 aa)
	HDAC6	Histone deacetylase 6. (1122 aa)
	PCGF3	Polycomb group ring finger 3. (242 aa)
	KDM1B	Lysine demethylase 1B. (826 aa)
	RLIM	Ring finger protein, LIM domain interacting. (609 aa)
	BEND3	BEN domain containing 3. (828 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (597 aa)
	MPHOSPH8	Chromo domain-containing protein. (362 aa)
	HELLS	Helicase, lymphoid specific. (822 aa)
	CTCF	CCCTC-binding factor. (727 aa)
	MACROH2A1	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	LHX2	LIM homeobox 2. (384 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	BAZ2A	Bromodomain adjacent to zinc finger domain 2A. (1878 aa)
	ARID4A	AT-rich interaction domain 4A. (1268 aa)
	G3T2J1_LOXAF	Uncharacterized protein. (405 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1236 aa)
	CTCFL	CCCTC-binding factor like. (646 aa)
	SIRT1	Sirtuin 1. (605 aa)
	G3T3L6_LOXAF	Uncharacterized protein. (262 aa)
	SMCHD1	SMC hinge domain-containing protein. (645 aa)
	SMYD5	SMYD family member 5. (417 aa)
	RIF1	Replication timing regulatory factor 1. (2441 aa)
	HAT1	Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (422 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (747 aa)
	TASOR	Transcription activation suppressor. (1618 aa)
	PCGF5	Polycomb group ring finger 5. (256 aa)
	LRIF1	Ligand dependent nuclear receptor interacting factor 1. (640 aa)
	EPC1	Enhancer of polycomb homolog. (842 aa)
	ZNFX1	Zinc finger NFX1-type containing 1. (1909 aa)
	EP300	E1A binding protein p300. (2420 aa)
	MORC2	MORC family CW-type zinc finger 2. (1033 aa)
	TRIM27	Tripartite motif containing 27. (615 aa)
	L3MBTL1	Uncharacterized protein. (741 aa)
	RBM15B	RNA binding motif protein 15B. (563 aa)
	RBM15	RNA binding motif protein 15. (959 aa)
	VPS72	Vacuolar protein sorting 72 homolog. (363 aa)
	MBD2	Methyl-CpG binding domain protein 2. (295 aa)
	METTL3	Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
	ZDBF2	Zinc finger DBF-type containing 2. (2248 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1854 aa)
	CREBZF	CREB/ATF bZIP transcription factor. (321 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (96 aa)
	SPHK2	Sphingosine kinase 2. (615 aa)
	GSK3A	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (482 aa)
	PRDM14	PR/SET domain 14. (510 aa)
	ZNF335	Zinc finger protein 335. (1345 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (469 aa)
	G3TGQ4_LOXAF	Uncharacterized protein. (409 aa)
	G3THQ5_LOXAF	RING-type domain-containing protein. (330 aa)
	EXOSC10	Exosome component 10. (887 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (587 aa)
	BAHD1	Bromo adjacent homology domain containing 1. (779 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (466 aa)
	CDYL	Chromodomain Y like. (542 aa)

Your Current Organism:

Loxodonta africana

NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID4A	ARID4B	ENSLAFP00000007267	ENSLAFP00000022187	AT-rich interaction domain 4A.	AT-rich interaction domain 4B.	0.776
ARID4A	EPC1	ENSLAFP00000007267	ENSLAFP00000009701	AT-rich interaction domain 4A.	Enhancer of polycomb homolog.	0.661
ARID4A	HDAC6	ENSLAFP00000007267	ENSLAFP00000003196	AT-rich interaction domain 4A.	Histone deacetylase 6.	0.804
ARID4A	HELLS	ENSLAFP00000007267	ENSLAFP00000005926	AT-rich interaction domain 4A.	Helicase, lymphoid specific.	0.587
ARID4A	KDM1B	ENSLAFP00000007267	ENSLAFP00000003725	AT-rich interaction domain 4A.	Lysine demethylase 1B.	0.662
ARID4A	MBD2	ENSLAFP00000007267	ENSLAFP00000011833	AT-rich interaction domain 4A.	Methyl-CpG binding domain protein 2.	0.607
ARID4A	MBD3	ENSLAFP00000007267	ENSLAFP00000025476	AT-rich interaction domain 4A.	Methyl-CpG binding domain protein 3.	0.607
ARID4A	MECP2	ENSLAFP00000007267	ENSLAFP00000013674	AT-rich interaction domain 4A.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.607
ARID4A	METTL3	ENSLAFP00000007267	ENSLAFP00000011840	AT-rich interaction domain 4A.	Methyltransferase like 3; Belongs to the MT-A70-like family.	0.606
ARID4A	MTA1	ENSLAFP00000007267	ENSLAFP00000029044	AT-rich interaction domain 4A.	Metastasis associated 1.	0.671
ARID4A	RB1	ENSLAFP00000007267	ENSLAFP00000028512	AT-rich interaction domain 4A.	RB transcriptional corepressor 1.	0.903
ARID4A	SMARCD1	ENSLAFP00000007267	ENSLAFP00000000537	AT-rich interaction domain 4A.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1.	0.484
ARID4A	VPS72	ENSLAFP00000007267	ENSLAFP00000011228	AT-rich interaction domain 4A.	Vacuolar protein sorting 72 homolog.	0.703
ARID4B	ARID4A	ENSLAFP00000022187	ENSLAFP00000007267	AT-rich interaction domain 4B.	AT-rich interaction domain 4A.	0.776
ARID4B	EPC1	ENSLAFP00000022187	ENSLAFP00000009701	AT-rich interaction domain 4B.	Enhancer of polycomb homolog.	0.671
ARID4B	HDAC6	ENSLAFP00000022187	ENSLAFP00000003196	AT-rich interaction domain 4B.	Histone deacetylase 6.	0.804
ARID4B	HELLS	ENSLAFP00000022187	ENSLAFP00000005926	AT-rich interaction domain 4B.	Helicase, lymphoid specific.	0.587
ARID4B	KDM1B	ENSLAFP00000022187	ENSLAFP00000003725	AT-rich interaction domain 4B.	Lysine demethylase 1B.	0.662
ARID4B	MBD2	ENSLAFP00000022187	ENSLAFP00000011833	AT-rich interaction domain 4B.	Methyl-CpG binding domain protein 2.	0.607
ARID4B	MBD3	ENSLAFP00000022187	ENSLAFP00000025476	AT-rich interaction domain 4B.	Methyl-CpG binding domain protein 3.	0.607

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