STRINGSTRING
HIPK3 HIPK3 BMP2 BMP2 BMP4 BMP4 PAQR3 PAQR3 LAX1 LAX1 INPP5K INPP5K DUSP19 DUSP19 SH2B3 SH2B3 LYN LYN DAB2IP DAB2IP GBA GBA CDK5RAP3 CDK5RAP3 SPRY2 SPRY2 SORL1 SORL1 G3SRX5_LOXAF G3SRX5_LOXAF AIDA AIDA ADIPOQ ADIPOQ DUSP16 DUSP16 IRAK3 IRAK3 HMGCR HMGCR PTPRJ PTPRJ PTPN1 PTPN1 TMEM130 TMEM130 NF1 NF1 SPRY3 SPRY3 CAV3 CAV3 SFRP2 SFRP2 MAPK8IP1 MAPK8IP1 SMPD1 SMPD1 CAV1 CAV1 SPRY1 SPRY1 PRKCD PRKCD PTPN6 PTPN6 AGT AGT G3TRX3_LOXAF G3TRX3_LOXAF CBLC CBLC PIK3CB PIK3CB DUSP10 DUSP10 APOE APOE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HIPK3Homeodomain interacting protein kinase 3. (1214 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
PAQR3Progestin and adipoQ receptor family member 3. (311 aa)
LAX1Lymphocyte transmembrane adaptor 1. (415 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (466 aa)
DUSP19Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (207 aa)
SH2B3SH2B adaptor protein 3. (568 aa)
LYNTyrosine-protein kinase. (512 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
GBAGlucosylceramidase. (516 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (491 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
SORL1Sortilin related receptor 1. (2220 aa)
G3SRX5_LOXAFIg-like domain-containing protein. (305 aa)
AIDAUncharacterized protein. (306 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (245 aa)
DUSP16Dual specificity phosphatase 16. (663 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (588 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (890 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1053 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (414 aa)
TMEM130Transmembrane protein 130. (376 aa)
NF1Neurofibromin 1. (2840 aa)
SPRY3Sprouty RTK signaling antagonist 3. (222 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (706 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (185 aa)
SPRY1Sprouty RTK signaling antagonist 1. (318 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (701 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
AGTAngiotensinogen; Belongs to the serpin family. (475 aa)
G3TRX3_LOXAFUncharacterized protein. (240 aa)
CBLCCbl proto-oncogene C. (503 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
APOEApolipoprotein E. (314 aa)
Your Current Organism:
Loxodonta africana
NCBI taxonomy Id: 9785
Other names: African bush elephant, African savanna elephant, African savannah elephant, L. africana, Loxodonta africana africana, elephant
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